Incidental papillary microcarcinoma of the thyroid—factors affecting lymph node metastasis

Gülben, Kaptan; Berberoğlu, Uğur; Çelen, Orhan; Mersin, Hüsnü H.

doi:10.1007/s00423-007-0213-2

Cited by 54 publications

(52 citation statements)

References 25 publications

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“…ECS is an important prognostic characteristic of CLNM. ECS in patients with CLNM was significantly increased compared with that in those without CLNM in the present study, which was confirmed by certain previous reports (27,32). In the present study, coexisting chronic lymphocytic thyroiditis was found in 21.7% of patients with PTMC.…”

Section: Discussionsupporting

confidence: 92%

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

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Abstract. Central lymph node metastasis (CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of the present study was to investigate the risk factors associated with CLNM in clinical lateral cervical lymph node-negative (cN0) PTMC in Eastern China. A total of 392 patients with confirmed PTMC by histological examination who underwent thyroidectomy and central neck lymph node dissection (CND) between May 2011 and October 2012 at the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China) were enrolled. The clinicopathological and ultrasonographic data from the patients were analyzed retrospectively. A scoring system was developed on the basis of independent predictive factors for CLNM. Male gender, age <45 years, maximum tumor diameter >5 mm, lower lobe location, multifocal carcinoma with total tumor diameter >10 mm and extracapsular spread were independent predictive factors for CLNM according to logistic regression analysis. The clinicopathological score was statistically significant, with an index point ≥2 indicating CLNM with 86.2% sensitivity and 70.4% specificity. The findings of the present study indicate that CND may be recommended to be routinely performed when the clinicopathological index point ≥2.

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Section: Discussionsupporting

confidence: 92%

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

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“…Table 3 reports the studies utilized for the analysis; the studies by Gü lben et al (151) and Besic et al (152) were not included since we had direct access to the full text after the calculations of our study were completed.…”

Section: Risk Factors For Recurrence and Mortalitymentioning

confidence: 99%

Thyroid papillary microcarcinoma: a descriptive and meta-analysis study

Roti

Uberti

Bondanelli

et al. 2008

European Journal of Endocrinology

285

229

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The authors review anatomical, clinical characteristics and prevalence of thyroid microcarcinoma. Diagnostic procedures and risk factors of aggressiveness at diagnosis and during follow-up are also covered. The possible clinical, pathologic and therapeutic risk factors are analyzed by meta-analysis study. Treatment procedures by different authors and guidelines suggested by societies are reported.European Journal of Endocrinology 159 659-673

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“…23 Lenf dü-ğümü metastazları multifokal mikrokarsinomlarda tek odaklı tümörlere göre daha yüksek orandadır. 7,32,33 Ayrıca semptomatik veya tesadüfi olmayan PMK'lerde prognoz asemptomatik veya tesadüfi olanlara göre daha kötüdür. 31 Benzer bir çalışmada, klinik olarak asemptomatik PMK'de lenf düğümü metastazı %3,6 iken, semptomatik PMK'lerde bu oran %35 olarak bulunmuştur.…”

Section: Discussionunclassified

The Importance of Tumor Size in Differentiated Thyroid Carcinomas

Hasbek¹,

Turgut²,

Erselcan³

et al. 2012

Turkiye Klinikleri J Med Sci

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733Diferansiye Tiroid Karsinomlarında Tümör Boyutunun Önemi Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, diferansiye tiroid karsinomlarında tümör boyutunun, diğer risk parametreleri ile olan ilişkisini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada tiroid karsinomu tanısı almış, bilateral total/totale yakın tiroidektomi yapılmış ve yüksek doz 131I ile tedavi almış olan hasta verileri geriye dönük olarak incelenmiştir. Tümör boyutu ≤1 cm ve >1 cm olanlarda, tümör boyutu ile histopatolojik sınıflandırma, cinsiyet, yaş, tümörün multifokalitesi (birden çok odakta tümör tutulumu) ve lenf düğümü tutulumu arasındaki ilişki değerlendirilmiştir. B Bu ul lg gu ul la ar r: : Ça-lışmaya, 237 (%83,2)'si kadın, 48 (%16,8)'i erkek olmak üzere toplam 285 hasta dâhil edilmiştir. Hastalardan 245 (%86)'i papiller karsinom olarak rapor edilmiştir. Tümörün tek odakta olduğu 23 erkek hastanın 6 (%26,1)'sında tümör ≤1 cm iken, multifokalite izlenen 14 hastanın 5 (%35,7)'inde tümör ≤1 cm bulunmuştur. Sadece erkek hastalar dikkate alındığında, tümör boyutu ≤1 cm olanlarda multifokalite oranı daha yüksek bulunmuştur. Tümör boyutu ≤1 cm olan 97 hastanın 32 (%33)'sinde tümör multifokal iken, >1 cm olan 116 hastanın 46 (%39,7)'sında birden çok odakta tutulum saptanmıştır. Tümör boyutunun ≤1 cm ve >1 cm olması arasında multifokalite bakımından istatistiksel olarak belirgin fark saptanmamıştır (p=0,31). Yaşı ≥45 olan, tümörün tek odakta izlendiği 65 hastanın 37 (%56,9)'sinde tümör ≤1 cm iken, multifokalite izlenen 32 hastanın 21'inde (%65,6) tümörün ≤1 cm olarak belirlenmiştir. Yaşı ≥45 olan hasta grubunda tümör boyutu ≤1 cm olan hastalarda tümörün multifokal olma oranı, >1 cm olanlara göre daha yüksek bulunmuştur. S So on nu uç ç: : Tümör boyutu ≤1 cm olan, risk faktörü bulunmayan hastalarda lobektomi ve istmektominin yeterli olduğu ve ablasyon tedavisinin gerekli olmadığı önerilmekle birlikte, multifokalite oranının yüksek olması nedeniyle özellikle papiller mikrokarsinomlarda da total tiroidektomi ve ablasyon tedavisinin yapılmasının uygun olduğunu düşünmekteyiz.A An na ah ht ta ar r K Ke el li im me el le er r: : Tiroid tümörleri; iyot; tiroidektomi A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : We aimed to assess the correlation of tumor size with other risk parameters in differentiated thyroid carcinomas. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Data of patients diagnosed with thyroid carcinoma, underwent bilateral total/near total thyroidectomy and treated with high doses of 131I were examined retrospectively. In patients with tumor size ≤1 cm and >1 cm, the correlation between the tumor size and histopathologic classification, gender, age, multifocality and lymphnode was assessed. R Re es su ul lt ts s: : The study included 285 patients; 237 (83.2%) were female, 48 (16.8%) were male. Two hundred and forty five patients (86%) had papillary carcinoma. The tumor was ≤1 cm in 6out of 23 male cases with a single focus (26.1%) and in 5 out of 14 male patients with multi...

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Incidental papillary microcarcinoma of the thyroid—factors affecting lymph node metastasis

Abstract: Patients with thyroid PMC in low-risk group with multifocal tumors and with capsule invasion may have increased risk of lymph node metastasis, and must be considered in follow-up of the patients who have these factors.

Cited by 54 publications

References 25 publications

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Thyroid papillary microcarcinoma: a descriptive and meta-analysis study

The Importance of Tumor Size in Differentiated Thyroid Carcinomas

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