Incidental oral plasmablastic lymphoma with aberrant expression of CD4 in an elderly HIV‐negative patient: how a gingival polyp can cause confusion

Tzankov, Alexandar; Brunhuber, Thomas; Gschwendtner, Andreas; Brunner, Andrea

doi:10.1111/j.1365-2559.2004.01990.x

Cited by 27 publications

(18 citation statements)

References 9 publications

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“…For example, important clinical characteristics that underline recently reported series include a strong predilection to the male gender and constant extranodal localization. In addition, cases in the transplant setting and cutaneous localization have also been described recently [3,5•,6,7], and HIV-negative cases continue to be described [8]. PBL of the oral mucosa type (Fig.…”

Section: Plasmablastic Lymphomamentioning

confidence: 85%

Diffuse large B-cell lymphomas with plasmablastic differentiation

Teruya‐Feldstein

2005

Curr Oncol Rep

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Recent evidence suggests that diffuse large B-cell lymphoma (DLBCL) with plasmablastic differentiation represents a clinically heterogeneous spectrum with different clinicopathologic characteristics representing distinct entities. Subtypes of DLBCL with plasmablastic features and terminal B-cell differentiation include plasmablastic lymphoma (PBL) of oral mucosa type; PBL with plasmacytic differentiation; primary effusion lymphoma (PEL); KSHV-positive solid lymphoma/extracavitary PEL/HHV-8 associated DLBCL; and DLBCL expressing ALK. In contrast, PBL associated with multicentric Castleman disease, DLBCL with secretory differentiation, pyothorax-associated lymphoma, and atypical Burkitt lymphoma with plasmacytoid differentiation have morphologic appearances of plasma cell differentiation but maintain a mature B-cell (CD20 positive) phenotype. These tumors as well as extramedullary plasmablastic tumors secondary to multiple myeloma or plasmacytomas are included in the differential diagnosis. In this review, we discuss recently described clinicopathologic insights, case observations, and recently reported molecules involved in terminal B-cell or plasma cell differentiation and their possible roles in disease pathogenesis.

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Section: Plasmablastic Lymphomamentioning

confidence: 85%

Diffuse large B-cell lymphomas with plasmablastic differentiation

Teruya‐Feldstein

2005

Curr Oncol Rep

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“…There are limited case reports in the literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Upper Aero-Digestive Tract Lymphomas Presenting as Polypoidal/Pedunculated Lesions: Case Report and Review of Literature

Akhtar

Rana

Aldei

et al. 2013

Head and Neck Pathol

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Aim To describe a case of diffuse large B cell lymphoma (DLBCL) presenting as a pedunculated/polypoidal mass in upper aero-digestive tract and to review pertinent literature. Methods Using Pubmed advanced search, case reports and literature were reviewed for this condition.Results A 16 year old female presented with history of shortness of breath when lying down, voice change, progressing odynophagia and feeling of throat lump. Direct visualization showed flower like pedunculated mass, attached to the left lateral oropharyngeal wall. Excision of this mass showed DLBCL and no disease anywhere. She received four cycles of Rituximab ? CHOP and is diseasefree for 4 years. Only 21 cases of pedunculated upper aerodigestive tract lymphomas have been reported in literature. Median age 53 years (16-90 years), males 80 %, females 20 %, localized disease (65 %). Common sites were endobronchial polypoid lesion (7 cases), nasal polyps (7), nasopharyngeal polyps (2), nose and paranasal sinus (1), laryngeal polyp (2) and one each as gum, esophagus and oropharyngeal (current case) polyp. Pathology showed aggressive lymphoma in 94 %. Conclusion DLBCL as an extranodal pedunculated lesion in the oropharynx is very rare. Careful pathological evaluation is essential for these lesions for proper diagnosis.

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“…Only four cases of PBL in the oral cavity have been reported in non-HIV patients 5,[8][9][10] . Most of the reported cases of PBL (about 90%) are associated with HIV positive patients.…”

Section: Discussionmentioning

confidence: 99%