Incidental lipoma-like hibernoma arising from the adrenal gland: A well-differentiated liposarcoma mimicker

Val-Bernal, J. Fernando; Azueta, Ainara; Ortiz-Rivas, Luis Antonio; Fuentes, Javier Segovia; Ballestero, Roberto

doi:10.1016/j.prp.2013.07.009

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Histologically, the tumour is composed of primitive embryonal fat characterized by multi-vacuolated Val-Bernal et al 2013). The patient also had a cortical adenoma producing primary hyperaldosteronism.…”

Section: Rare Primary Lipomatous Tumoursmentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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Adrenal lipomatous tumour is a group of adrenal tumours with a significant component of adipose tissue. According to the current World Health Organization (WHO) classification of tumours of endocrine organs, adrenal myelolipoma is the only entity amongst the group of tumours being described. In the literature, other more recently documented adrenal lipomatous tumours included 24 lipomas, 32 teratomas and 16 angiomyolipomas. Rare fatty tumours of the adrenal gland comprised liposarcoma, hibernoma, adrenocortical tumours with fat component and rare adrenal tumours with fat component. Myelolipoma comprises approximately 3% of primary adrenal tumour. It is noted more commonly in females and in the right adrenal gland. Approximately 40 bilateral myelolipomas were reported. The tumour is most frequently recorded in patients between fifth and seventh decades of life. Adrenal lipomas are often seen in males and in the right adrenal gland. They were commonly noted in patients in the sixth decade of life. The diagnosis could only be possible on examination of the surgically removed specimen. Adrenal teratomas were more common in females and with a bimodal age distribution. Slightly over 60% of the patients with adrenal teratoma are symptomatic. Adrenal angiomyolipomas were often symptomatic, more common in females and in the fifth decades of life. To conclude, adrenal lipomatous tumour is uncommon. They are often benign and non-functional. It is important to recognize the features of this group of lipomatous tumours in the adrenal gland as they are being detected on increasing incidence as a result of the wide-spread use of modern imaging modalities.

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Section: Rare Primary Lipomatous Tumoursmentioning

confidence: 99%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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“…Another case was described by Val-Bernal et al in a 55-year-old female; it was an incidentally discovered mass of 26 mm associated with Conn's syndrome. The hibernoma measured 17 mm and consisted of univacuolated mature adipose cells with central or paracentral nuclei [4]. Adrenal hibernoma combined with a pheochromocytoma was found in our patients at a younger age as their tumors were discovered incidentally in the operating room.…”

Section: Discussionmentioning

confidence: 60%

“…Indeed, our two patients benefited from a surgical resection by laparoscopy with a good outcome. To our knowledge, no malignant transformation has been reported in the literature [4].…”

Section: Discussionmentioning

confidence: 79%

Rare Cases of Hibernomas Associated With Bilateral Pheochromocytoma: A Report of Two Cases

Bentaleb¹,

Essouabni²,

Aynaou³

et al. 2023

Cureus

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Hibernoma is an infrequent benign lipomatous tumor that shows differentiation to brown fat. It is a slowly growing tumor of variable consistency but often firmer than a classic lipoma, mobile, and rarely infiltrating. To date, there are only a few cases of adrenal hibernoma in the literature.Herein, we report two cases. The first one is that of a 24-year-old female presenting with a bilateral adrenal incidentaloma discovered in the setting of abdominal pain whose histological study individualized a bilateral pheochromocytoma associated with a hibernoma. The second case is that of a young male of 23 years old. He was operated on in adolescence (age 14) for a left pheochromocytoma. The outcome was marked by the recurrence of the Menards triad ("headache, palpitations, and sweating") and hypertension at the age of 23 years. It was due to the appearance of a contralateral right pheochromocytoma, whose histological study showed an association with a hibernoma, and the genetic study revealed Von Hippel-Lindau (VHL) disease.

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“…Hibernomas are rare and benign lipomatous tumors which consists of lobules of cells derived from brown fat [ 1 ]. Less than 200 overall cases are reported in the literature which necessitates the need to report more cases for better understanding of this neoplasm [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Unlike conventional lipomas, hibernomas have granular eosinophilic cytoplasm and multivacuolated cells with numerous lipid droplets [ 6 ]. In addition, they have small and bland central nuclei with rare mitotic figures or atypia [ 1 ]. Lipoma-like hibernomas consist of mostly mature univacuolated adipocytes with sparse eosinophilic granular and few multivacuolated brown fat cells [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Lipoma-like hibernoma: a rare soft tissue tumor—a case series and review of the literature

Gabra,

Sacasa,

Baig

et al. 2023

Journal of Surgical Case Reports

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Hibernomas are rare and benign lipomatous tumors which consist of lobules of cells derived from brown fat. Less than 200 overall cases are reported in the literature which necessitates the need to report more cases for better understanding of this neoplasm. Hibernomas are slowly progressing, painless tumors most frequently located in the subcutaneous thigh, upper trunk, and neck. Hibernomas generally occur in areas close to the axial skeleton where brown fat used to exist in the fetus and persisted during adulthood. They are rare to be discovered for the first time in older adults, most commonly presenting in adults 20–40 years of age. Core biopsies are simple to perform under local anesthetic and provide pathological differentiation prior to planned excision, hence are recommended, especially with larger lesions. Based on case presentation, watchful waiting for non-growing asymptomatic cases of hibernoma is possible, but more frequent follow-up and/or a core biopsy would be advised to rule out a more aggressive diagnosis. Compared with lipoma-like hibernomas, atypical lipomatous tumor/well-differentiated liposarcoma recurs and might dedifferentiate to a dedifferentiated liposarcoma with the ability to metastasize in up to 5% of the recurrences. Hibernomas, including the lipoma-like variant, are typically treated by surgical excision, rarely recur and do not metastasize. We report two rare presentations of hibernoma and lipoma-like hibernoma. Awareness of this clinicopathological entity is crucial to avoid misdiagnosis as malignant lipomatous neoplasm.

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Incidental lipoma-like hibernoma arising from the adrenal gland: A well-differentiated liposarcoma mimicker

Cited by 7 publications

References 15 publications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Rare Cases of Hibernomas Associated With Bilateral Pheochromocytoma: A Report of Two Cases

Lipoma-like hibernoma: a rare soft tissue tumor—a case series and review of the literature

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