Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease

Genç, Volkan; Kırımker, Elvan Onur; Akyol, Cihangir; Kocaay, Akın Fırat; Karabork, Ayca; Tüzüner, Acar; Erden, Esra; Karayalçın, Kaan

doi:10.4318/tjg.2011.0250

Cited by 21 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we found that in other studies conducted in the Turkish population this ratio was consistent with ours and was lower than that in the literature (25)(26)(27). Genc et al (25) reported the incidental gallbladder cancer rate in 5164 cholecystectomies as 0.09%, Dursun et al (26) in 696 cases as 0.3%, while Akyurek et al (27) detected the rate as 0,72% in 548 cases.…”

Section: Discussioncontrasting

confidence: 55%

Incidental gallbladder cancers: Our clinical experience and review of the literature

Düzköylü

Bektaş

Kozluklu

2016

UCD

View full text Add to dashboard Cite

Objective: Gallbladder carcinomas are rare and aggressive neoplasms. They are usually advanced at the time of diagnosis. We aimed to evaluate incidental gallbladder cancers in our clinic, in terms of patients' demographics, diagnosis, treatment and follow-up, and compared our results with the literature. Material and Methods:Patients who underwent laparoscopic cholecystectomy in the last 9 years were retrospectively reviewed, and features of the patients diagnosed with gallbladder cancer after histopathological evaluation were further evaluated.Results: Thirteen patients were female and two were male. The mean age was 67 years. Additional treatment was applied in seven patients. All patients were operated on laparoscopically, with conversion to open surgery in four patients. The rate of incidental gallbladder cancer was 0.17% in our patients. Survival rates were found to be 22.2% in patients who had been operated at least 5 years ago. Conclusion:Surgery is the only curative treatment in gallbladder cancers; however, they are usually at advanced stages at the time of diagnosis. In incidental gallbladder cancers, survival can be prolonged with appropriate treatment models if they are identified at early stages. The relatively low rates that have been reported in our population may be due to geographical differences and problems in study design. Keywords: Incidental, gallbladder, cancer INTRODUCTIONLaparoscopic cholecystectomy is accepted as the gold standard for the treatment of benign gallbladder diseases in the world due to reduced postoperative pain, early oral intake, early discharge and better cosmetic results for the last 20 years, and is being implemented with low morbidity. There has not been a significant increase in the early detection rate of gallbladder cancer (GBC), which remains asymptomatic in early stages, despite advances in technology and widespread use of techniques such as ultrasound (US) and abdominal computed tomography (CT), with an incidence of 0,54-2,1% (1, 2). Overall, there is preoperative suspicion of GBC in only 30% of patients, while the remaining 70% are diagnosed in the postoperative pathologic examinations (3). In other words, in the literature it has been proven that 1 cancer is detected out of every 100 laparoscopic cholecystectomies (4). Maximillian Stoll has mentioned GBC for the first time in Vienna in 1777 (5). After many years, Nevin et al. (6) has defined the first GBC staging and survival rates after open cholecystectomy. Drouard et al. (7) showed port site metastases in 1991. Gallbladder cancer is a very aggressive disease, with a 5-year survival rate of 3-13% (8), and a mean survival of 3-11 months (9). However, especially with aggressive surgical approaches applied in some centers in Japan, satisfactory results can be obtained (10). The underlying cause of this rate is the too late emergence of symptoms such as pain and jaundice (6), and advanced stage on diagnosis (T3, T4).Incidental GBC refers to cancers that were not diagnosed preoperatively but detected by postoper...

show abstract

Section: Discussioncontrasting

confidence: 55%

Incidental gallbladder cancers: Our clinical experience and review of the literature

Düzköylü

Bektaş

Kozluklu

2016

UCD

View full text Add to dashboard Cite

show abstract

“…Importantly, our analysis suggests that a 1% incidence of iGBC is an overestimation in the current era, which is consistent with other recent retrospective studies. 10,25,26 Another important finding of this study is that OC patients had a significantly higher incidence of iGBC (1.13%) than patients who underwent an LC (0.07%; relative risk = 17.3). Furthermore, patients who converted from LC to OC had a significantly higher rate of iGBC (0.60%) than patients who had their procedure performed completely laparoscopically (0.05%).…”

Section: Resultsmentioning

confidence: 89%

Incidental Gallbladder Cancer at Cholecystectomy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…GC is the fifth most common gastrointestinal cancer (4,8) . The prognosis is usually poor and mainly depends on tumor stage.…”

Section: Discussionmentioning

confidence: 99%

“…Sujata et al (9) reported 6 (0.9%) incidental GC in 622 laparoscopic cholecystectomy specimen. Genc et al (8) reported 5 (0.09%) incidental gallbladder carcinoma in 5164 patients and they supposed that the low incidence in Turkish population is related to the avoidance of elective cholecystectomy in advanced stage carcinomas. In our study, the rate of incidental gallbladder cancer was 0.11%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidental Gallbladder Carcinoma and Precancerous Lesions In Laparoscopic Cholecystectomy Specimens

Keskin¹,

Pala²,

Çakır³

et al. 2017

Terh

View full text Add to dashboard Cite

Objective: The purpose of our study was to find out the frequency of incidental carcinomas, dysplasias and adenomas of the gallbladder in patients who underwent laparoscopic cholecystectomy. Methods:We reviewed pathology records of 5063 cholecystectomy specimens Hematoxylin-eosin stained sections of the patients having dysplasia, adenoma, gallbladder carcinoma (GC) were reviewed. Results: Incidental GC was detected in 6 cases, and 5 of them exhibited accompanying dysplasia. Isolated cases of dysplasia, and adenoma were detected in 13, and 2 cases, respectively. Femalemale ratios for dysplasia, and carcinoma were 12: 1, and 4: 2, respectively. Median ages of GC, and dysplasia/adenoma were 65.6, and 56.8 years, respectively. Biliary intraepithelial neoplasia (BillN3) and BillN2 were accompanied with 4, and 1 case with carcinoma. Intestinal metaplasia was noted in 3 carcinoma cases. Isolated cases with BillN3, BillN2, and BillN1without invasive carcinoma were seen in 4, 3, and 6 cases, respectively. Intestinal metaplasia was noted in 2, intestinal+pyloric metaplasia in 1, and pyloric metaplasia in 1 case with BillN. Conclusion: Incidental GC was found in 0.11% of our cases. Gallbladder stones and advance age seem to be the risk factors for GC. Incidental GC may be predicted in the presence of BillN and metaplastic changes of the gallbladder. Histopathological evaluation is still important for the diagnosis of incidental gallbladder carcinoma and preinvasive lesions. BillN3 is typically associated with invasive carcinoma. Thus, complete sampling should be performed by pathologist when carcinoma is not evident on initial histologic sections.

show abstract

Incidental gallbladder cancer diagnosed during or after laparoscopic cholecystectomy in members of the Turkish population with gallstone disease

Cited by 21 publications

References 24 publications

Incidental gallbladder cancers: Our clinical experience and review of the literature

Incidental gallbladder cancers: Our clinical experience and review of the literature

Incidental Gallbladder Cancer at Cholecystectomy

Incidental Gallbladder Carcinoma and Precancerous Lesions In Laparoscopic Cholecystectomy Specimens

Contact Info

Product

Resources

About