Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline

Engel, Doortje C.; Pirpamer, Lukas; Hofer, Edith; Schmidt, Reinhold; Brendle, Cornelia

doi:10.1186/s12987-021-00268-x

Cited by 11 publications

(13 citation statements)

References 54 publications

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“…Unfortunately, we only had access to TMT B at follow-up. However, another study found that TMT B scores were worse for individuals who later were classi ed as having iNPH [49]. We cannot infer if this would have been the case in our study, but our results at follow-up coincides with other studies showing di culties with shifting in iNPH [20,49].…”

Section: Discussionsupporting

confidence: 70%

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

Lilja-Lund

Maripuu

Kockum

et al. 2023

Preprint

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Background: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce. Aim: To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material. Method: A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p <0.05 were used. Results: Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045). Conclusion: Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.

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Section: Discussionsupporting

confidence: 70%

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

Lilja-Lund

Maripuu

Kockum

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…In 113 people who were imaged at baseline and a follow-up 3 to 5 years later, people with idiopathic normal pressure hydrocephalus at follow-up had more WMHs and, despite being asymptomatic, had evidence of subclinical cognitive decline and worse executive function, memory, and Trail-Making Test B scores. 137…”

Section: Brain Healthmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

3,218

702

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BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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“…Unfortunately, we only had access to TMT B at follow-up. However, another study found that TMT B scores were worse for individuals who later were classified as having iNPH [ 49 ]. We cannot infer if this would have been the case in our study, but our results at follow-up coincides with other studies showing difficulties with shifting in iNPH [ 20 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, another study found that TMT B scores were worse for individuals who later were classified as having iNPH [ 49 ]. We cannot infer if this would have been the case in our study, but our results at follow-up coincides with other studies showing difficulties with shifting in iNPH [ 20 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

et al. 2023

View full text Add to dashboard Cite

Background Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce. Aim To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material. Method A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used. Results Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045). Conclusion Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.

show abstract

Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline

Cited by 11 publications

References 54 publications

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study

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