Incidental Finding of Fatty Liver in Autopsies

Bravo-Espinoza, I.E.; Arist-Urista, G.; Durán-Padilla, Marco A; Pérez-Hernández, J.L.; López-Pérez, R.Y.; Pérez-Santos, P.L.; Montenegro-Tablada, J.L.; Escobedo-Uribe, J.; Servín-Caamaño, A.; Tijera, Fátima Higuera-de la

doi:10.1016/j.aohep.2021.100604

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“…In an autopsy study by Alagarsamy et al [14], cases with a normal liver histology accounted for only 22%, while fatty changes were 20%, hepatitis 10%, congestion 26%, and cirrhosis 16% of the total autopsies performed. A similar incidence of liver disease has also been reported by other authors [15][16][17][18]. It should be emphasised that although the presence of fat in the liver induces lipid peroxidation and the generation of oxidative stress, necrosis or fibrosis of the tissue does not always occur.…”

Section: Introductionsupporting

confidence: 83%

Linking Metallic Micronutrients and Toxic Xenobiotics to Atherosclerosis and Fatty Liver Disease—Postmortem ICP-MS Analysis of Selected Human Tissues

et al. 2023

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Dyslipidaemia is a disorder of the lipid metabolism, caused mainly by poor eating habits. The most severe consequence of an inappropriate diet is the development of atherosclerosis and hepatic steatosis. It is generally believed that a change in nutrition, and increased physical activity can eliminate these health problems. The contemporary research and therapies used to treat dyslipidemia mainly focus on lowering the triglyceride and cholesterol levels. However, disturbances in trace element homeostasis or the accumulation of toxic elements can also affect physiological processes, and be involved in the development of metabolically mediated diseases. The present study aimed to determine the mineral profiles of liver and brain tissues collected at autopsy (n = 39) in groups of people with hepatic steatosis (n = 5), atherosclerosis (n = 9), hepatic steatosis, and atherosclerosis (n = 16), and others without the selected disorders (n = 9). Concentrations of 51 elements were analysed via inductively coupled plasma mass spectrometry (ICP-MS) after the initial wet mineralisation of the samples with nitric acid. The results obtained allow us to conclude that the hepatic steatosis group suffers from a deficiency of important trace elements, such as copper, zinc, and molybdenum (p < 0.05), whereas the group with atherosclerosis is characterised by elevated levels of cadmium in the liver tissue (p = 0.01). Analysing the mean values of the element concentrations measured in 11 brain areas, statistically significant higher levels of calcium and copper (p < 0.001) were found in the atherosclerosis group, compared to the hepatic steatosis group, confirming the involvement of these elements in the pathogenesis of atherosclerosis. In addition, an accumulation of cadmium, lead, titanium, and strontium in the brain tissue was observed in the atherosclerosis group. While the accumulation of individual elements differs in different parts of the brain, the differences in the cadmium content (p < 0.05) between the study groups apply to the whole brain, except for the nucleus accumbens septi area, where a statistically significant titanium accumulation occurs in the atherosclerosis and steatosis groups, compared to the others (p < 0.05). In addition, the disruption of elemental homeostasis in the brain of a single case with bipolar disorder, and a case with hip replacement was observed. Our results confirm the involvement of chemical elements in the pathogenesis of selected metabolic diseases, and the need for further studies in larger populations.

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Section: Introductionsupporting

confidence: 83%