“…Coronary anomalies such as anomalous left circumflex coronary artery (LCA) arising from the right sinus of Valsalva, strictly leaning on the aortic annulus, can have serious consequences in AV/ root surgery, particularly if unrecognized or underestimated. 3,4 In this paper, we present three patients with an anomalous course of the LCA undergoing AV replacement (AVR) with three different prostheses, without prosthetic downsizing. If open surgery is not indicated or alternative technique are not available, transcatheter AV implantation has been described with success, using when necessary, a coronary guidewire before deploying transcatheter aortic valve implantation to prevent coronary occlusion/stenosis.…”