Incidental Detection of Occult Thyroid Carcinoma with 11C-Choline PET/CT for High Risk Prostate Cancer

Ouattara, Adama; Oliveira, Tiago; Holz, Serge; Bossche, Hannes Van Den; Strybol, David; Assenmacher, Christophe; Everaerts, Wouter; Meerleer, Gert De; Joniau, Steven

doi:10.1159/000447184

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…However, a retrospective study of 368 patients focusing exclusively on abnormal F-choline uptake in the thyroid gland at PET/CT found two cases of thyroid carcinoma out of nine cases of atypical thyroid uptake (32). Case reports also demonstrated that focal uptake of F-choline in the thyroid should raise suspicion for malignancy (33)(34)(35). Thus, in agreement with the conclusion of a recent literature review evaluating the prevalence and clinical significance of focal incidental radiolabeled choline uptake in the thyroid gland (36), any abnormal thyroid uptake at F-choline PET/CT should be explored with at least a TSH and calcitonin assay and an ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

Unusual uptakes on 18F-fluorocholine positron emission tomography/computed tomography (PET/CT): a retrospective study of 368 prostate cancer patients referred for a biochemical recurrence or an initial staging

Roland¹,

Drouet²,

Boulahdour³

et al. 2021

Quant Imaging Med Surg

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Background: 18 F-fluorocholine positron emission tomography/computed tomography (F-choline PET/ CT) is considered a cornerstone in the staging and restaging of patients with prostate cancer (PCa). The aim of this study was to retrospectively assess unusual uptakes in patients who underwent a F-choline PET/CT for the initial staging or for the restaging of a relapsing PCa.Methods: Three hundred and sixty-eight PCa patients were staged or restaged using F-choline PET/CT.Unusual uptakes were defined as uptakes occurring outside the usual paths of diffusion of PCa or as uptake in bone with a clear morphological evidence of nonmetastatic lesion. Results:We found unusual uptakes in 47/368 patients (12.8%). Among them, 41/47 presented with benign F-choline uptake, usually within lymph nodes, due to inflammatory processes (22/47). Other benign processes were found in: thyroid (3/47), adrenal gland (3/47), brain (2/47), liver (1/47), bowel (3/47), frontal sinus (1/47), lungs (4/47), parotid gland (1/47) and bone (1/47). The six remaining patients presented with a second cancer, including lymphoma (1/47), non-small cell lung cancer (4/47) and neuroendocrine tumor (1/47).Conclusions: unusual uptakes on F-choline PET/CT are quite frequent and should be explored since they may correspond to non-PCa.

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Section: Discussionmentioning

confidence: 99%

Unusual uptakes on 18F-fluorocholine positron emission tomography/computed tomography (PET/CT): a retrospective study of 368 prostate cancer patients referred for a biochemical recurrence or an initial staging

Roland¹,

Drouet²,

Boulahdour³

et al. 2021

Quant Imaging Med Surg

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Nuclear medicine imaging modalities to detect incidentalomas and their impact on patient management: a systematic review

Costanzo,

Scalia,

Strigari

et al. 2024

J Cancer Res Clin Oncol

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Purpose This systematic review aims to investigate the role of nuclear imaging techniques in detecting incidentalomas and their impact on patient management. Methods Following PRISMA guidelines, a comprehensive literature search was conducted from February to May 2022. Studies in English involving patients undergoing nuclear medicine studies with incidental tumor findings were included. Data on imaging modalities, incidentaloma characteristics, management changes, and follow-up were extracted and analyzed. Results Ninety-two studies involving 64.884 patients were included. Incidentalomas were detected in 611 cases (0.9%), with thyroid being the most common site. PET/CT with FDG and choline tracers showed the highest incidentaloma detection rates. Detection of incidentalomas led to a change in therapeutic strategy in 59% of cases. Various radiotracers demonstrated high sensitivity for incidentaloma detection, particularly in neuroendocrine tumors and prostate cancer. Conclusion Nuclear imaging techniques play a crucial role in detecting incidentalomas, leading to significant changes in patient management. The high sensitivity of these modalities highlights their potential in routine oncology follow-up protocols. Future directions may include enhancing spatial resolution and promoting theranostic approaches for improved patient care.

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PET/CT in thyroid nodule and differentiated thyroid cancer patients. The evidence-based state of the art

Piccardo

Trimboli

Foppiani

et al. 2019

Rev Endocr Metab Disord

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Incidental Detection of Occult Thyroid Carcinoma with 11C-Choline PET/CT for High Risk Prostate Cancer

Cited by 7 publications

References 8 publications

Unusual uptakes on 18F-fluorocholine positron emission tomography/computed tomography (PET/CT): a retrospective study of 368 prostate cancer patients referred for a biochemical recurrence or an initial staging

Unusual uptakes on 18F-fluorocholine positron emission tomography/computed tomography (PET/CT): a retrospective study of 368 prostate cancer patients referred for a biochemical recurrence or an initial staging

Nuclear medicine imaging modalities to detect incidentalomas and their impact on patient management: a systematic review

PET/CT in thyroid nodule and differentiated thyroid cancer patients. The evidence-based state of the art

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