Incidental Detection of Follicular Thyroid Carcinoma in ⁶⁸Ga-PSMA PET/CT Imaging

Abstract

Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein. It has been shown to be expressed in various solid malignant neoplasms. We report a case of a prostate cancer patient who underwent 68 Ga-PSMA PET/CT imaging. There is a large thyroid nodule in the right thyroid gland, which had intense PSMA accumulation. Follicular thyroid lesions can be seen on 68 Ga-PSMA PET/CT imaging.

Expression of PSMA in Thyroid follicular neoplasms: Utility for differentiating between benign from malignant lesions

“…A PSMA -Avid thyroid lesion was identified which on further histologic exam was diagnosed as FTA. [23] Incidental FTC with increased uptake also reported by Sager et al, [24] in a known case of prostate cancer. In another report by Tawade et al [25] they believes that it was more effective in detection of multiple mediastinal, lung and supra-clavicular lymph nodes and brain metastatic lesions in a patient with rising thyroglobulin and negative whole body radioiodine scan.…”

“…[22][23][24][25][26] For example, in a report by Kanthan et al [23] a known case of prostate cancer underwent […”

“…[22][23][24][25][26] This study is conducted to evaluate the expression of PSMA by Immunohistochemistry in neovasculature of thyroid follicular neoplasms to determine its usefulness for distinguishing between adenoma and carcinoma. Also, to evaluate the potential capability of radio labeled Anti PSMA antibody as complementary target therapy in advanced thyroid malignancies.…”

PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET/MRI

“…[78] PSMA uptake is also seen in both benign[9] and malignant neoplasms of thyroid. [101112] Although rare, metastatic spread to the thyroid gland from primary PCa has been reported in the past. [1314] In this patient, metastases to the thyroid was a distinct possibility in view of widespread metastatic disease not observed in this case.…”

A new perspective for nuclear medicine: expanding the indications for PSMA targeted imaging and therapy

“…Incidental findings on PSMA PET/CT performed for prostate cancer have already expanded this list of PSMA expressing tumours by e.g. renal cell carcinoma and thyroid cancer [23][24][25][26][27][28][29][30][31].…”