Incidental Detection of Elastofibroma Dorsi With 68Ga-FAPI-46 and 18F-FDG PET/CT in a Patient With Esophageal Cancer

Hayrapetian, Artineh; Girgis, Mark D.; Yanagawa, Jane; French, Samuel W.; Schelbert, Heinrich R.; Auerbach, Martin; Czernin, Johannes; Calais, Jérémie

doi:10.1097/rlu.0000000000003218

Cited by 15 publications

(10 citation statements)

References 8 publications

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“…In our study, 68 Ga-FAPI uptake of elastofibroma dorsi was higher in a patient than 18 F-FDG, consistent with the study by Hayrapetian et al 38 Similar to the study by Lan et al, 39 68 Ga-FAPI uptake was higher in the fracture observed in the rib in the same patient. In a case with focal 68 Ga-FAPI uptake in the pancreas, laboratory and radiological findings were evaluated in favor of pancreatitis, and 68 Ga-FAPI uptake due to pancreatitis has been reported in the literature 20,39 .…”

Section: Discussionsupporting

confidence: 92%

68Ga-FAPI-04 PET/CT in Selected Breast Cancer Patients With Low FDG Affinity

et al. 2023

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PurposeIn this prospective study, PET findings of 18F-FDG PET/CT in breast cancer staging were compared with 68Ga–FAP inhibitor (FAPI) 04 PET/CT findings in selected cases with relatively low 18F-FDG uptake in the primary tumor or with suspected nodal or distant metastases.Patients and MethodsTwenty-four women with a median age of 45 years (range, 36–67 years) who underwent initial staging 18F-FDG PET/CT for breast cancer underwent 68Ga-FAPI-04 PET/CT imaging within the same week. SUVmax and quantities of primary tumors and locoregional and distant metastatic lesions were recorded from both images, and these data were compared statistically.ResultsThe histological subtypes of primary tumors were 11 invasive lobular, 8 invasive ductal, and 5 mucinous subtypes. More intense 68Ga-FAPI-04 uptake (mean, 17.1 ± 7.9; 7.4–38.5) was detected in all primary tumoral lesions compared with 18F-FDG (mean, 6.3 ± 3.9; 1.5–20.5) (P = <0.001, Z = 4.107). Additional lesions showing 68Ga-FAPI-04 uptake in the breast were detected in 29.2% (n = 7) of patients. In 8.3% (n = 2) of the patients, the primary lesion showed only 68Ga-FAPI-04 uptake. In 68Ga-FAPI-04 PET/CT, 25% (n = 6) of the patients showed more lymph node involvement and more intense uptake in the ipsilateral axilla. In addition, infraclavicular (level 3) lymph nodes in 4 patients (16.7%), supraclavicular lymph nodes in 1 patient, and internal mammary lymph nodes in 1 patient were detected only on 68Ga-FAPI-04 PET/CT. In a patient with lung and bone metastases, 68Ga-FAPI-04 uptake was higher, and the lung nodule showed only 68Ga-FAPI-04 uptake.ConclusionsIn selected low-FDG-affinity breast cancer patients, 68Ga-FAPI-04 PET/CT showed the primary tumor with higher sensitivity and higher SUVmax values compared with 18F-FDG PET/CT. In addition, it is believed that this method may contribute to the management of patients' treatment by increasing the nodal stage.

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Section: Discussionsupporting

confidence: 92%

68Ga-FAPI-04 PET/CT in Selected Breast Cancer Patients With Low FDG Affinity

et al. 2023

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“…The blood perfusion status of the lesion can be directly evaluated based on the value of these perfusion parameters to reflect its development. At the same time, it can also judge the MVD and then evaluate the activity, pathological grade, and prognosis of the tumor (14). Tumor angiogenesis is the basic process of its growth and metastasis, and it is the physiological basis for tumor proliferation, nutrition supply, and metabolite elimination.…”

Section: Discussionmentioning

confidence: 99%

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

Dong

Feng

et al. 2021

J Gastrointest Oncol

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Background: This article aims to analyze the correlation between microvessel density (MVD) and multispiral CT(MSCT) perfusion parameters of esophageal cancer lesions, and the diagnostic value of combining C-terminal binding protein 2 (CtBP2) and P16 inhibitor of cyclin-dependent kinase 4a (P16 INK4A ). Methods: A total of 42 cases of normal esophageal mucosa tissues >5 cm from the cancer tissue were selected as the control group. The expression levels of CtBP2 and P16 INK4A and the values of MSCT perfusion parameters and MVD were compared in the control group and esophageal cancer group. SP immunohistochemical staining was used to detect protein expression levels of CtBP2 and P16 INK4A . The Pearson method was used to analyze the differences and pertinence of MSCT perfusion parameters and MVD in the control group and esophageal cancer group. The receiver operating characteristic (ROC) curve was used to calculate the diagnostic value of CtBP2 and P16 INK4A combined with MVD and MSCT perfusion parameters in esophageal cancer.Results: The positive expression rate of P16 INK4A in the esophageal cancer group was significantly lower than that in the control group. The positive expression rates of CtBP2, blood volume (BV), mean transit time (MTT), surface permeability (permeability surface, PS), and MVD values were significantly higher than those of the control group (P<0.05). There was no significant difference in blood flow (BF) value between the 2 groups (P>0.05). The BF value of the tumor invading the fibrous membrane was significantly higher than that of the non-invading fibrous membrane (P<0.05), and the PS and MVD values of the patients with lymph node metastasis were higher than those without lymph node metastasis (P<0.05). The MSCT perfusion parameters BF and BV were significantly positively correlated with MVD (P<0.05), while MTT, PS, and MVD were not significantly correlated (P>0.05). ROC results showed that the areas under curve (AUC) of CtBP2, P16 INK4A , and MSCT were 0.625, 0.747, and 0.812, respectively. However, the area under the combined detection curve was larger, at 0.869. Conclusions: MSCT perfusion imaging of esophageal cancer lesions can indirectly reflect the angiogenesis of esophageal cancer, and the combination of CtBP2 and P16 INK4A can effectively improve the diagnostic efficiency of the disease.

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“…Besides PSMA, there are multiple other targets discussed for their potency in PET/CT diagnostics or radioligand therapy. The fibroblast-activating protein (FAP) is used in 68Ga-Fibroblast activation protein inhibitor (FAPI) PET/CT [ 16 , 17 ] as well as 64Cu- and labelled with 225Ac FAPI combined in a “theranostics” approach [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy

Hager

Borchert

Wessolly

et al. 2023

IJMS

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Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy and chemotherapeutics, with cisplatin being the drug of choice, but response rates of only up to 14% indicate very poor outcomes. Effective treatment options are lacking. Besides the diagnostic usage of radioligands in positron emission tomography (PET)/computed tomography (CT), the endo-radioligand therapy with Lu177 has been proven as a powerful tool in cancer therapy. Mesothelin (MSLN) and C-XC chemokine receptor 4 (CXCR4) are membrane-bound proteins, expressed in certain cancers, and thus are promising targets for endo-radiotherapy. A significant portion of high MSLN- or CXCR4-expressing tumors within the MPM may open the field for this sophisticated treatment approach in the near future. Formalin-fixed, paraffin-embedded (FFPE) tumour specimens from 105 patients suffering from MPM and treated at the Lung Cancer Centre of Essen and at the Helios Klinikum Emil von Behring Berlin were screened. The tumour samples were arranged in tissue microarrays. We immunohistochemically stained the tumour samples against MSLN and CXCR4. The protein expressions of the stainings were scored by a pathologist by using a semiquantitative method. The data obtained were correlated with the clinical outcome. Overall, 77.1% of the analysed tumours showed CXCR4 protein expression (25.7% of them at high expression level (Score 3)). 48.6% of all samples showed an overall strong staining (Score ≥ 2), 59% of the investigated tumours showed MSLN protein expression (10.5% of them at high expression (Score 3)), and 36.2% of all samples showed an overall strong staining (Score ≥ 2). Our results show significant tissue expression levels, for both CXCR4 and MSLN protein, in a major portion of clinical MPM samples. One-third of patients showed outstanding immunoexpression of at least one of these markers, making them interesting candidates for radioligand-based PET/CT diagnostics and follow-up and furthermore may profit from endo-radiotherapy.

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Incidental Detection of Elastofibroma Dorsi With 68Ga-FAPI-46 and 18F-FDG PET/CT in a Patient With Esophageal Cancer

Cited by 15 publications

References 8 publications

68Ga-FAPI-04 PET/CT in Selected Breast Cancer Patients With Low FDG Affinity

68Ga-FAPI-04 PET/CT in Selected Breast Cancer Patients With Low FDG Affinity

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy

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