Incidental colorectal FDG uptake on PET/CT scan and lesions observed during subsequent colonoscopy: a systematic review

Kousgaard, Sabrina Just; Thorlacius-Ussing, Ole

doi:10.1007/s10151-017-1652-6

Cited by 28 publications

(32 citation statements)

References 39 publications

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“…This indicates that malignancy rates of incidental FDG-PET/CT lesions may vary among organs. Incidental uptake on FDG-PET/CT in the colon or rectum has been described in several studies [7]. Focal colorectal FDG uptake can indicate a variety of lesions, both benign and malignant.…”

Section: Methodsmentioning

confidence: 97%

“…In a systematic review of 26 studies, the median number of included patients was 35. Only four studies included > 100 patients, one with a maximum of 239 patients [7]. Only a few studies performed diagnostic work-up of patients with incidental colorectal FDG uptake but negative colonoscopy, or performed systematic colonoscopy in all the included patients with incidental FDG uptake [9].…”

Section: Methodsmentioning

confidence: 99%

“…Other studies reported a strong correlation between incidental colorectal FDG uptake and the lesion observed during colonoscopy [15][16][17][18]. Yet no management algorithm exists to suggest the optimal management of patients with incidental colorectal PET-avid lesions, and the decision whether to perform further diagnostic evaluation can be difficult [7].…”

Section: Methodsmentioning

confidence: 99%

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Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

et al. 2020

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Background and study aims Further diagnostics of incidental colorectal lesions on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is questionable. Therefore, we aimed to evaluate the clinical importance of incidentally detected colorectal lesions on FDG-PET/CT. Patients and methods In the North Denmark Region, a retrospective study was performed among 19,987 patients who had an FDG-PET/CT from January 2006 to December 2015. Among these patients, we identified patients with a colonoscopy within 12 months from the PET/CT scan and a description of incidental colorectal PET-avid lesions on the PET/CT. PET findings were compared with colonoscopy-detected lesions and eventually histopathology. Results Incidental PET-avid lesions were observed in 549 patients. Colonoscopy revealed lesions in 457 (83 %), among whom 338 patients had a final histopathological diagnosis. Malignant and premalignant lesions were found in 297 patients (54 % among patients with a PET-avid lesion). The lesions were cancer in 76 patients and adenoma in 221 patients of whom 30 had high-grade and 191 low-grade adenomas. The findings changed patient management in 166 cases (30 % of all patients with a PET-avid lesion). A colonoscopy-based surveillance program was initiated for 80 % of patients with high-grade adenoma. No patients with PET-avid lesions but normal colonoscopy developed colorectal cancer during 3 years of observation (median observation time 7 years). Conclusions Incidental colorectal FDG uptake was infrequently observed, but when present, it was associated with a high rate of malignant or premalignant lesions. Our results indicate that patients with incidental colorectal FDG uptake should be referred to diagnostic work-up including colonoscopy.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

et al. 2020

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“…Incidental imaging findings in a tissue or organ in patients without signs or symptoms of disease in that tissue (incidentalomas) are frequently occurring [ 1 ]. Incidental findings with 18F-fluorodeoxyglucose positron emission tomography/computer tomography (FDG PET/CT) has been reported in several tissues [ 2 ], including colon [ 3 ], prostate [ 4 ], breast [ 5 ], and the adrenal glands [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Frequency of Focal Thyroid Incidental Findings and Risk of Malignancy Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography in an Iodine Deficient Population

et al. 2018

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Incidental focal uptake of 18F-fluorodeoxyglucose (FDG) in the thyroid on positron emission tomography (PET/CT) is rare but often associated with malignancy. The epidemiology of thyroid incidentalomas has only to some extent been described in countries with iodine deficiency. Here we report data from Denmark, a country with known iodine deficiency and wide access to PET/CT. All FDG PET/CT comprising the head and neck region, during 2014, were retrospectively reviewed, and patients with focal FDG uptake in the thyroid gland were identified. A total of 2451 patients had an FDG PET/CT of which 59 (2.4%) patients presented with FDG-avid focal lesions in the thyroid gland. Among the 59 patients with FDG-avid lesions, 33 patients (56%) received work up with ultrasound, thyroid technetium scintigraphy, fine needle aspiration, and/or histology of which 20 patients had a conclusive pathology report. Ten patients with FDG-avid lesions were identified with thyroid malignancy. The risk of thyroid malignancy was 16.9% among patient with incidental FDG-avid thyroid lesions. Our findings indicated a similar frequency of FDG thyroid incidentalomas and malignancy rates in an iodine deficient population compared to summary data from prior studies, studies mostly performed in geographical areas of normal or excess iodine supplementation.

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“…It can disclose incidental uptake across different organs, including the colon (as in our case), rectum, lung, etc. [ 4 ]. Multiple primary cancer (MPC) is rare.…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography With Fluorodeoxyglucose Incidental Detection of Colon Cancer in a Patient’s Follow-Up for Nasopharyngeal Carcinoma During the COVID-19 Pandemic: A Case Report

Basendowah¹,

Alshaynawi²,

Madani³

et al. 2020

Cureus

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Colorectal cancer (CRC) is a type of widespread, deadly malignancy that took thousands of lives around the globe. In the last two decades, CRC represented the most common cancer among men and ranked third among women in Saudi Arabia. Positron emission tomography with fluorodeoxyglucose (FDG-PET), can incidentally detect malignancy, as in our case, FDG-PET disclosed high abnormal FDG far away from the first primary malignancy. The current case is of a 65-year-old female who was following up on her nasopharyngeal carcinoma (first primary). During her last management, FDG-PET was requested to find any FDG uptake in the nasopharyngeal region; stunning FDG uptake was incidentally found at the ascending colon diagnosed as early-stage (pT2N0) colon cancer. Colonoscopy was done and India Ink was injected to facilitate localizing the mass during the laparoscopic removal of the tumor, which was delayed due to the pandemic of COVID-19. This took place in March 2020 at King Abdul-Aziz University Hospital in Jeddah.

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Incidental colorectal FDG uptake on PET/CT scan and lesions observed during subsequent colonoscopy: a systematic review

Cited by 28 publications

References 39 publications

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

Incidental detection of colorectal lesions on 18F-FDG-PET/CT is associated with high proportion of malignancy: A study in 549 patients

The Frequency of Focal Thyroid Incidental Findings and Risk of Malignancy Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography in an Iodine Deficient Population

Positron Emission Tomography With Fluorodeoxyglucose Incidental Detection of Colon Cancer in a Patient’s Follow-Up for Nasopharyngeal Carcinoma During the COVID-19 Pandemic: A Case Report

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