Incidental colonic focal FDG uptake on PET/CT: can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy?

Hoeij, Froukje B. van; Keijsers, Ruth G.; Loffeld, B. C. A. J.; Dun, Guoliang; Stadhouders, P.H.G.M.; Weusten, Blam

doi:10.1007/s00259-014-2887-3

Cited by 42 publications

(43 citation statements)

References 21 publications

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“…Similar findings have been reported for cohorts with other primary cancer types (35,36), and the prevalence in our material is at a comparable level. The additional work-up generated by the findings is an important factor in evaluating the cost-effectiveness of 18 F-FDG PET/CT, since follow-up examinations are costly and often yield negative results.…”

Section: Discussionsupporting

confidence: 92%

Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

et al. 2015

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Our objective was to prospectively explore the diagnostic value of 18 F-FDG PET/CT for preoperative staging in endometrial carcinomas and to investigate whether 18 F-FDG PET-specific quantitative tumor parameters reflect clinical and histologic characteristics. Methods: Preoperative 18 F-FDG PET/CT was prospectively performed on 129 consecutive endometrial carcinoma patients. Two physicians who did not know the clinical findings or staging results independently reviewed the images, assessing primary tumor, cervical stroma involvement and metastatic spread, and determining maximum and mean standardized uptake value (SUV max and SUV mean , respectively) for tumor, metabolic tumor volume (MTV), and total lesion glycolysis (TLG). All parameters were analyzed in relation to histomorphologic and clinical tumor characteristics. Receiver-operatingcharacteristic curves for identification of deep myometrial invasion and lymph node metastases were generated, and MTV cutoffs for predicting deep myometrial invasion and lymph node metastases were calculated. Results: The sensitivity, specificity, and accuracy of 18 F-FDG PET/CT for the detection of lymph node metastases were 77%-85%, 91%-96%, and 89%-93%, respectively. SUV max , SUV mean , MTV, and TLG were significantly related to deep myometrial invasion, presence of lymph node metastases, and high histologic grade (P , 0.015 for all) and independently predicted deep myometrial invasion (P , 0.015) and lymph node metastases (P , 0.025) after adjustment for preoperative histologic risk (based on subtype and grade) in endometrial biopsies. Optimal cutoffs for MTV in predicting deep myometrial invasion (20 mL) and the presence of lymph node metastases (30 mL) yielded odds ratios of 7.8 (P , 0.001) and 16.5 (P 5 0.001), respectively. Conclusion: 18 F-FDG PET/CT represents a clinically valuable tool for preoperatively evaluating the presence of lymph node metastases in endometrial carcinoma patients. Applying MTV cutoffs for the prediction of deep myometrial invasion and lymph node metastases may increase diagnostic accuracy and aid preoperative identification of high-risk patients, enabling restriction of lymphadenectomy for patients with a low risk of aggressive disease.

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Section: Discussionsupporting

confidence: 92%

Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

et al. 2015

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“…However, cerebral hypoperfusion in the brain 3D-ASL maps was only observed in the bilateral middle frontal and the right superior gyrus in these patients. The difference in the cerebral changes between the two methods may be associated with molecular biological changes of the brain in depression disorder (20) and also may result from the different imaging mechanisms used in the two techniques (21,22). The current findings from dual-mode imaging not only imply that FDG PET is more sensitive than 3D-ASL in identifying functional abnormalities, but also suggest that the prefrontal lobe may be the principal brain region involved in depression.…”

Section: Discussionmentioning

confidence: 99%

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Shi

Gao

et al. 2017

Experimental and Therapeutic Medicine

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The aim of this study was to explore the functions of cerebral blood perfusion and glucose metabolism in the prefrontal lobe of patients with major depression disorder (MDD), and to analyze the correlations between these functional changes and depressive symptoms. 3D-arterial spin labeling (ASL) and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were successfully performed in 17 patients with MDD and 16 healthy controls in a resting state. The depressive symptoms of the patients were classified into seven factors and scored with the Hamilton Depression Rating Scale. Regional cerebral blood flow (CBF) values and standardized uptake values (SUV) of 18F-FDG in the whole brain were respectively compared between the patients and healthy controls using a two-sample t-test, and the correlations between the CBF and SUV in the prefrontal cerebral regions with the patients' Hamilton scores were evaluated using Pearson correlation analysis. Decreased regional CBF was indicated in the bilateral middle and the right superior frontal gyri, and decreased regional SUV was indicated in the bilateral superior, middle and inferior frontal gyri in the MDD patients compared with the controls. Positive correlations were observed between CBF values and aggregate Hamilton scores in the left middle and right middle frontal gyri of the patients. Positive correlations were also observed between SUVs and aggregate Hamilton scores in the left middle and right middle frontal gyri. 18F-FDG PET/CT was indicated to be more sensitive than 3D-ASL in identifying the functional abnormalities in the prefrontal lobe. Decreased CBF and SUV in the prefrontal lobe were closely correlated with Hamilton score. The left middle frontal gyrus may be a key functional region in MDD.

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“…[18] For adenocarcinoma of the colon, the median SUVmax is similar, around 16.6. [19] The CT findings of bowel thickening, nodularity and dilatation may be seen in PTLD as well as adenocarcinoma. Hence, for a colonic mass with widespread metastasis such as liver, lymph nodes and skin, PET-CT may not differentiate PTLD from adenocarcinoma, necessitating a colonoscopy for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Postrenal transplant metastatic colonic neoplasm: Posttransplant lymphoproliferative disorder or adenocarcinoma?

Lal¹,

Yadav²,

Dey³

et al. 2017

Indian J Nephrol

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Transplant recipients are vulnerable to a horde of infections and neoplastic conditions due to immunosuppression. Posttransplant lymphoproliferative disorder (PTLD) is a condition unique to the transplant recipient occurring due to monoclonal lymphocytic proliferation. It may affect any organ system with reportedly highest incidence in the gastrointestinal tract. The incidence of adenocarcinoma of the colon, however, has not been shown to be uniformly higher in transplant recipients. We report here an unusual case of adenocarcinoma of the ascending colon presenting with liver, lymph node and skin metastasis in a transplant recipient, which simulated PTLD both clinically and radiologically. For any gastrointestinal lesion in transplant recipient, the possibility of carcinoma must be considered. However, a high index of suspicion for PTLD facilitates early diagnosis since the treatment of the two conditions is starkly different.

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Incidental colonic focal FDG uptake on PET/CT: can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy?

Cited by 42 publications

References 21 publications

Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Postrenal transplant metastatic colonic neoplasm: Posttransplant lymphoproliferative disorder or adenocarcinoma?

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Incidental colonic focal FDG uptake on PET/CT: can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy?

Cited by 42 publications

References 21 publications

Metabolic Tumor Volume on 18F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

Metabolic Tumor Volume on 18F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

Functional assessment of prefrontal lobes in patients with major depression disorder using a dual-mode technique of 3D-arterial spin labeling and 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Postrenal transplant metastatic colonic neoplasm: Posttransplant lymphoproliferative disorder or adenocarcinoma?

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Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients

Metabolic Tumor Volume on ¹⁸F-FDG PET/CT Improves Preoperative Identification of High-Risk Endometrial Carcinoma Patients