Incidental adult nesidioblastosis after distal pancreatectomy for endocrine microadenoma

Islet Hyperplasia in Adults: Challenge to Preoperatively Diagnose Non‐Insulinoma Pancreatogenic Hypoglycemia Syndrome

“…We questioned whether specific clinical and biochemical data might point toward a preoperative diagnosis of NIPHS rather than a pathohistological diagnosis. From the literature, 4,8,9,11,12,[17][18][19][20][21][22][23][24][25][26][28][29][30][31][32][33][34][35][36][37][38] we estimated a mean age of 44 years in 64 patients with NIPHS compared with 41 years in our series of 11 patients and 49 years in our 70 patients with insulinoma. NIPHS has been reported to occur throughout the lifespan from 11 to 84 years and there was a female preponderance (39 women, 25 men).…”

Nesidioblastosis and Insulinoma: A Rare Coexistence and a Therapeutic Challenge

“…The association of these two entities is a rare clinical finding. To the best of our knowledge, the association between nesidioblastosis and neoplastic diseases of the endocrine pancreas has been described in just a few cases (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). The peculiarity of our case is that the diagnoses of nesidioblastosis and insulinoma were not concomitant.…”

Concurrent Adult-Onset Diffuse β-Cell Nesidioblastosis and Pancreatic Neuroendocrine Tumor: A Case Report and Review of the Literature

“…Nineteen cases of WD-PNET and β-cell nesidioblastosis arising in the same patient have been described previously 4,6-20 (Table 1). Thirteen of the 19 cases occurred in women.…”