Incidental 68Ga–Prostate-Specific Membrane Antigen Uptake in Compression Fracture of a Vertebral Body

Abstract

Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein, which is overexpressed in prostate cancer cells. With its wide use, there is a growing number of case reports describing non–prostate cancer–related benign and malignant lesions showing increased 68Ga-PSMA uptake. We herein present the case of an 89-year-old man with prostate cancer who was referred for 68Ga-PSMA PET/CT for restaging, which revealed incidental 68Ga-PSMA uptake in compression fracture of a vertebral body. This case demonstrates that PSMA expression may occur in acute compression fractures, and it can be a potential pitfall when reporting 68Ga-PSMA PET/CT images.

The occurrence and development of vertebral osteoporosis regulated by IL-8

“…[ 4 ] The patient’s bone healing process is slow, the quality of life is low, and it is easy to lead to various complications, which not only increases the risk of disability and death, but also brings a heavy economic burden to the patient’s family. [ 5 ] Osteoporotic fractures of the vertebral body are most common in the elderly. Because of the OP of the elderly, minor violence can cause compression fractures of the vertebral body.…”

PSMA Uptake in a Subdural Hematoma

“…PSMA uptake has also been described in nonmalignant processes such as within lung consolidation from increased capillary permeability, 1 as well as Paget disease, which is thought secondary to osteoblastic activity 5 . Other nonprostatic entities have also demonstrated uptake of radiotracer, including a intracranial dermoid cyst, 6 corpus luteum, 7 compression fracture, 8 COVID-19 pneumonia, 9 and tubercular spondylitis 10 . Normal brain parenchyma shows a complete absence of PSMA radiotracer uptake secondary to an intact blood-brain barrier that the radiopharmaceutical does not normally cross 1 .…”