Incidental 18F-FDG uptake in the thyroid in patients diagnosed with PET/CT for other malignancies

Czepczyński, Rafał; Stangierski, Adam; Oleksa, Robert; Janicka‐Jedyńska, Małgorzata; Czarnywojtek, Agata; Ruchała, Marek; Sowiński, Jerzy

doi:10.5603/nmr.2011.00018

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…Significantly higher 18 F-FDG uptake with a diffuse pattern of accumulation was described in patients with chronic thyroiditis [20] and Graves’ disease [21] . The incidence and potential explanation of focal uptake of 18 F-FDG within the thyroid gland have already been evaluated in some studies [3] , [5] – [12] , [11] , [25] – [27] . The diagnostic role of SUV max in thyroid incidentalomas is not fully elucidated, as the published data on the differential diagnosis of benign and malignant thyroid nodules were inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the use of (18)F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET and PET/CT) has evolved to become one of the fundamental diagnostic tools in the evaluation of patients with different malignancies [1] , [2] , [3] , [4] . According to several analyses performed in the last decade, about 1.2–4.3% of subjects undergoing this procedure, due to oncological indications, present focal uptake of 18 F-FDG in the thyroid gland [5] , [6] , [7] , [8] , [9] , [10] .…”

Section: Introductionmentioning

confidence: 99%

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The Usefulness of Standardized Uptake Value in Differentiation between Benign and Malignant Thyroid Lesions Detected Incidentally in 18F-FDG PET/CT Examination

et al. 2014

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IntroductionIn the last decade, (18)F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET and PET/CT) has become one of the major diagnostic tools used in oncology. A significant number of patients who undergo this procedure, due to non-thyroidal reasons, present incidental uptake of (18F-FDG) in the thyroid. The aim of the study was to compare the SUVmax (standardized uptake value) of thyroid focal lesions, which were incidentally found on PET/CT, in relation to the results of thyroid fine-needle aspiration biopsy (FNAB) and/or histopathological evaluation.Materials and MethodsPatients referred for PET/CT examination, due to non-thyroidal illness, presented focal 18F-FDG uptake in the thyroid and were advised to undergo ultrasonography (US), hormonal evaluation, FNAB and/or total thyroidectomy at our institution.Results6614 PET/CT examinations performed in 5520 patients were analyzed. Of the 122 patients with focal thyroid 18F-FDG activity, 82 patients (67.2%) underwent further thyroid evaluation using FNAB. Benign lesions were diagnosed in 46 patients, malignant - in 19 patients (confirmed by post-surgical histopathology), while 17 patients had inconclusive results of cytological assessment. Mean SUVmax of benign lesions was 3.2±2.8 (median = 2.4), while the mean SUVmax value for malignant lesions was 7.1±8.2 (median = 3.5). The risk of malignancy was 16.7% for lesions with a SUVmax under 3, 43.8% for lesions with a SUVmax between 3 and 6, and 54.6% for lesions with a SUVmax over 6. In the group of malignant lesions, a positive correlation between the lesion’s diameter and SUVmax was observed (p = 0.03, r = 0.57).ConclusionsSubjects with incidental focal uptake of 18F-FDG in thyroid are at a high risk of thyroid malignancy. A high value of SUVmax further increases the risk of malignancy, indicating the necessity for further cytological or histological evaluation. However, as SUVmax correlated with the diameter of malignant lesions, small lesions with focal uptake of 18F-FDG should be interpreted cautiously.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Usefulness of Standardized Uptake Value in Differentiation between Benign and Malignant Thyroid Lesions Detected Incidentally in 18F-FDG PET/CT Examination

et al. 2014

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“…Czepczyński et al [9], who analysed thyroid nodules found accidentally during positron emission tomography CT (PET-CT) with 18F-FDG, adopted assumptions similar to ours. The authors evaluated 1925 PET-CT scans performed to diagnose and determine the severity of cancers with extrathyroidal starting points.…”

Section: Discussionmentioning

confidence: 93%

Znaczenie przypadkowo rozpoznanego ogniskowego wychwytu 99mTc- sestamibi w tarczycy w trakcie scyntygrafii perfuzyjnej mięśnia sercowego

Giejda

Piszczek

Stembrowicz-Nowakowska

et al. 2015

Endokrynologia Polska

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“…Several publications reported that PET/CT is a competent examination for thyroid nodules with inconclusive cytologic results. 8 , 9 Giovanella et al 10 had suggested that PET/CT can be performed for LCH. In this case, PET/CT was performed to help make an accurate diagnosis of LCH involving thyroid.…”

Section: Discussionmentioning

confidence: 99%

A Case Report

Cai¹,

Wang

Ni³

et al. 2015

Medicine

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Langerhans cell histiocytosis (LCH) involving the thyroid gland is extremely rare. Currently, the diagnosis and therapeutic evaluation for LCH involving thyroid is a challenge.We reported a rare case of LCH involving thyroid, presenting as painless thyroid goiters, and successfully performed positron emission tomography/computed tomography (PET/CT) to make an accurate diagnosis and therapeutic evaluation for LCH.Although the histology or cytology is the golden standard for the diagnosis of LCH involving thyroid, the PET/CT should be keep in mind when LCH involving thyroid with inconclusive cytologic results. During the treatment of LCH, PET/CT can be performed to assess the therapeutic effect and select the most effective and reliable treatment for LCH.

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Incidental 18F-FDG uptake in the thyroid in patients diagnosed with PET/CT for other malignancies

Cited by 10 publications

References 22 publications

The Usefulness of Standardized Uptake Value in Differentiation between Benign and Malignant Thyroid Lesions Detected Incidentally in 18F-FDG PET/CT Examination

The Usefulness of Standardized Uptake Value in Differentiation between Benign and Malignant Thyroid Lesions Detected Incidentally in 18F-FDG PET/CT Examination

Znaczenie przypadkowo rozpoznanego ogniskowego wychwytu 99mTc- sestamibi w tarczycy w trakcie scyntygrafii perfuzyjnej mięśnia sercowego

A Case Report

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