Incident thyroid disease in female spouses of private pesticide applicators

Shrestha, Srishti; Parks, Christine G.; Goldner, Whitney; Kamel, Freya; Umbach, David M.; Ward, Mary H.; Lerro, Catherine C.; Koutros, Stella; Hofmann, Jonathan N.; Freeman, Laura E. Beane; Sandler, Dale P.

doi:10.1016/j.envint.2018.05.041

Cited by 25 publications

(20 citation statements)

References 43 publications

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“…• While hyperthyroidism (namely, an inappropriately high synthesis and secretion of TH by the thyroid) has been associated with pesticide exposure in human epidemiological studies (Shrestha et al, 2018), this thyroid condition has not been retained as specific effect in the sense of the present report. A first reason is that the prevalence of hyperthyroidism is lower than that of hypothyroidism and the latter has been more often reported to be associated with pesticide exposure in humans (Shrestha et al, 2018). A second reason is that hyperthyroidism is less frequently reported in regulatory studies on experimental animals.…”

Section: Effects Not Leading To Cagsmentioning

confidence: 60%

Establishment of cumulative assessment groups of pesticides for their effects on the thyroid

Crivellente¹,

Hart²,

Hernández‐Jerez³

et al. 2019

EFS2

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Cumulative assessment groups of pesticides have been established for two specific effects on the thyroid: firstly hypothyroidism, and secondly parafollicular cell (C-cell) hypertrophy, hyperplasia and neoplasia. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the thyroid, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.

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Section: Effects Not Leading To Cagsmentioning

confidence: 60%

Establishment of cumulative assessment groups of pesticides for their effects on the thyroid

Crivellente¹,

Hart²,

Hernández‐Jerez³

et al. 2019

EFS2

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“…Within the AHS cohort, endocrine disrupting pesticides atrazine (herbicide) and malathion (insecticide) have been associated with thyroid cancer risk in applicators and spouses, respectively (32,33). A number of pesticide ingredients have also been linked to incident self-reported thyroid disease in AHS applicators (34) and spouses (35,36). Furthermore, aldrin (insecticide) and pendimethalin (herbicide) have been associated with thyroid hormone dysfunction in AHS male pesticide applicators (37).…”

Section: Cancer Excessesmentioning

confidence: 99%

Cancer incidence in the Agricultural Health Study after 20 years of follow-up

Lerro

Koutros

Andreotti

et al. 2019

Cancer Causes Control

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Purpose: To evaluate cancer incidence in the Agricultural Health Study (AHS), a cohort of private pesticide applicators, their spouses, and commercial applicators, based on 12,420 cancers, adding 5,989 cancers and nine years of follow-up since last evaluation. Methods:We calculated age, year, sex, and race-adjusted standardized incidence ratios (SIR) and 95% confidence intervals (CI) for cancer sites in the AHS relative to the general population.Results: Overall AHS cancer incidence was lower than the general population (SIR private =0.91, CI:0.89-0.93; SIR spouse =0.89, CI:0.86-0.92; SIR commercial =0.83, CI:0.76-0.92), with notable deficits across applicators and spouses for oral cavity, pancreas, and lung cancers. Cancer excesses included prostate cancer, lip cancer, certain B-cell lymphomas (e.g multiple myeloma), acute myeloid leukemia (AML), thyroid cancer, testicular cancer, and peritoneal cancer. The lung cancer deficit was strongest among applicators reporting potential exposure to endotoxin at study enrollment (tasks such as raising animals and handling stored grain). Conclusions:Although an overall deficit in cancer was observed, there were notable exceptions, including newly-observed excesses for AML, thyroid, testicular, and peritoneal cancers. Furthermore, endotoxin exposure may, in part, account for observed lung cancer incidence deficits. Cancer incidence patterns in the AHS suggest farm exposures' relevance to cancer etiology.

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“…This was seen as an increased risk of either clinically diagnosed hypothyroidism or hyperthyroidism. 57,58…”

Section: Hypertrophy In the Pituitary Gland Pars Distalis In 2 Ntp Stmentioning

confidence: 99%

Proceedings of the 2019 National Toxicology Program Satellite Symposium

et al. 2019

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The 2019 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology’s 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and topics covered during the symposium included aging mouse lesions from various strains, as well as the following lesions from various rat strains: rete testis sperm granuloma/fibrosis, ovarian cystadenocarcinoma, retro-orbital schwannoma, periductal cholangiofibrosis of the liver and pancreas, pars distalis hypertrophy, chronic progressive nephropathy, and renal tubule regeneration. Other cases included polyovular follicles in young beagle dogs and a fungal blood smear contaminant. One series of cases challenged the audience to consider how immunohistochemistry may improve the diagnosis of some tumors. Interesting retinal lesions from a rhesus macaque emphasized the difficulty in determining the etiology of any particular retinal lesion due to the retina’s similar response to vascular injury. Finally, a series of lesions from the International Harmonization of Nomenclature and Diagnostic Criteria Non-Rodent Fish Working Group were presented.

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Incident thyroid disease in female spouses of private pesticide applicators

Cited by 25 publications

References 43 publications

Establishment of cumulative assessment groups of pesticides for their effects on the thyroid

Establishment of cumulative assessment groups of pesticides for their effects on the thyroid

Cancer incidence in the Agricultural Health Study after 20 years of follow-up

Proceedings of the 2019 National Toxicology Program Satellite Symposium

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