Incident SARS-CoV-2 Infection among mRNA-Vaccinated and Unvaccinated Nursing Home Residents

White, Elizabeth M.; Yang, Xiaofei; Blackman, Carolyn; Feifer, Richard A.; Gravenstein, Stefan; Mor, Vincent

doi:10.1056/nejmc2104849

Cited by 82 publications

(73 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the present report was not designed nor powered to estimate vaccine effectiveness, the vaccination failure rate against any (asymptomatic or symptomatic) RT-PCR-confirmed infection observed is consistent with the findings of the Danish study [26]. In a recent US study [27], the incidence of SARS-CoV-2 in vaccinated (n = 13,048) LTCF residents was 1.0% within 2 weeks after receipt of the second dose. By contrast, the incidence was 4.3% in non-vaccinated residents.…”

Section: Discussionsupporting

confidence: 84%

Outbreak of SARS-CoV-2 Lineage 20I/501Y.V1 in a Nursing Home Underlines the Crucial Role of Vaccination in Both Residents and Staff

et al. 2021

View full text Add to dashboard Cite

Elderly residents in nursing homes are at very high risk of life-threatening COVID-19-related outcomes. In this report, an epidemiological and serological investigation of a SARS-CoV-2 outbreak in an Italian nursing home is described. Among the residents, all but one (19/20) were regularly vaccinated against SARS-CoV-2. In mid-February 2021, a non-vaccinated staff member of the nursing home was diagnosed with the SARS-CoV-2 infection. Following the outbreak investigation, a total of 70% (14/20) of residents aged 77–100 years were found positive. The phylogenetic analysis showed that the outbreak was caused by the SARS-CoV-2 variant of concern 202012/01 (the so-called “UK variant”). However, all but one positive subjects (13/14) were fully asymptomatic. The only symptomatic patient was a vaccinated 86-year-old female with a highly compromised health background and deceased approximately two weeks later. The subsequent serological investigation showed that the deceased patient was the only vaccinated subject that did not develop the anti-spike protein antibody response, therefore being likely a vaccine non-responder. Although the available mRNA SARS-CoV-2 vaccine was not able to prevent several asymptomatic infections, it was able to avert most symptomatic disease cases caused by the SARS-CoV-2 variant of concern 202012/01 in nursing home residents.

show abstract

Section: Discussionsupporting

confidence: 84%

Outbreak of SARS-CoV-2 Lineage 20I/501Y.V1 in a Nursing Home Underlines the Crucial Role of Vaccination in Both Residents and Staff

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Considering also a recent report by White et al [ 17 ], the effectiveness of vaccination of nursing home guests should be much higher than that observed in our study.…”

Section: Discussioncontrasting

confidence: 52%

“…The fact that all observed cases were infected with the SARS-CoV-2 B.1.1.7 lineage, a variant not considered in the study by White et al [ 17 ], which has a 43–90% higher replication rate than the wild-type strain (the strain of virus that contains no major mutations) and an increased risk of death of 61% [ 18 , 19 ], does not fully account for such an excess of risk of infection and mortality.…”

Section: Discussionmentioning

confidence: 99%

An Outbreak of COVID-19 among mRNA-Vaccinated Nursing Home Residents

Faggiano

Rossi

Cena³

et al. 2021

Vaccines

View full text Add to dashboard Cite

An outbreak was described among the guests of a Long-Term Care Facility in the North of Italy. Among 23 guests, 20 of whom were fully vaccinated with BNT162b2 vaccine, the outbreak led to a final count of 11 positive guests, 9 of whom were vaccinated, and 4 positive healthcare workers, of whom only 1 was vaccinated. Eight of the positive guests (six vaccinated and two unvaccinated) had symptoms that in five cases (three vaccinated and two unvaccinated) led to death. The risk of infection and the risk of death appeared not to be correlated with the health status neither with the serological titer, but only with age.

show abstract

“…A similar COVID-19 incidence rate was reported among nursing home residents. According to data provided by White et al [40], 4.5% of cases were reported within 0 to 14 days of the rst dose and 1.4% of cases within 15 to 28 days. Among the subjects vaccinated with both doses of the vaccine, 1.0% were PCR positive within 0 to 14 days after the second dose, and 0.3% had a "'breakthrough" infection 14 days after full vaccination.…”

Section: Discussionmentioning

confidence: 99%

Differences in the concentration of anti-SARS-CoV-2 IgG antibodies post-COVID-19 recovery or post-vaccination

Tretyn

Szczepanek

Skorupa

et al. 2021

Preprint

View full text Add to dashboard Cite

At the end of 2020, population-based vaccination programs with new generation mRNA-based vaccines began almost all over the world. The aim of the study was to evaluate the titer of anti-SARS-CoV-2 IgG antibodies against the S1 subunit of the virus’s spike protein as a marker of the humoral response in 477 patients and the concentration of gamma interferon as an indicator of a cellular response in 28 individuals. In our studies, we used serological enzyme-linked immunosorbent assays. IgG was measured in weeks 2 and 3 after the first dose and 1–5 weeks after the second dose of an mRNA vaccine in seropositive and seronegative individuals as well as in symptomatic and asymptomatic convalescents. High levels of antibodies were observed in 98% of our vaccinated cohort, and the presence of protective T cells was confirmed in the blood samples of all participants. The humoral immune response is diversified and is visible as early as 2–3 weeks after the first dose of the mRNA vaccine. The level of protection increased significantly after the second dose, with the increase being much greater in pre-vaccine healthy subjects and less in convalescents. In the second and third weeks after the second dose, the concentration of IgG antibodies was the highest, and in the following weeks, it decreased gradually. Regular serological measurements on eight subjects show that antibody titers are lower four months after vaccination than before the second dose.

show abstract

Incident SARS-CoV-2 Infection among mRNA-Vaccinated and Unvaccinated Nursing Home Residents

Cited by 82 publications

References 3 publications

Outbreak of SARS-CoV-2 Lineage 20I/501Y.V1 in a Nursing Home Underlines the Crucial Role of Vaccination in Both Residents and Staff

Outbreak of SARS-CoV-2 Lineage 20I/501Y.V1 in a Nursing Home Underlines the Crucial Role of Vaccination in Both Residents and Staff

An Outbreak of COVID-19 among mRNA-Vaccinated Nursing Home Residents

Differences in the concentration of anti-SARS-CoV-2 IgG antibodies post-COVID-19 recovery or post-vaccination

Contact Info

Product

Resources

About