Incidence trends of viral hepatitis A, B, and C seropositivity over eight years of surveillance in Saudi Arabia

Memish, Ziad A.; Knawy, Bandar Al; El-Saed, Aiman

doi:10.1016/j.ijid.2009.03.027

Cited by 60 publications

(63 citation statements)

References 15 publications

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“…Most of our patients were Saudis, and this finding is consistent with the national data showing high prevalence of CHB among Saudis compared to non Saudis in the country [8,10]. Patients with HBeAg negative CHB were more likely to be older than HBeAg positive patients, which may be related to the natural history of vertically transmitted CHB and HBeAg sero-conversion over the years as the disease progresses from the immune-active phase to the active hepatitis B carrier stage [2][3][4]28].…”

Section: Discussionsupporting

confidence: 92%

“…Previously reported data on CHB from Saudi Arabia have focused on the prevalence of the disease [5][6][7] and the effect of HBV vaccination on reducing the rate of hepatitis B surface antigen (HBsAg) seropositivity in the country [9,10], but there are no similar data available that focus on the long-term follow-up or treatment outcome. HBV-DNA was found to be the best predictor of the severity of fibrosis, long-term outcome, progression to end-stage liver disease, the risk of hepatocellular carcinoma (HCC) and the response to therapy [2,3,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

Fallatah

Akbar

2010

J Infect Dev Ctries

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Introduction: The outcome of chronic hepatitis B (CHB) infection in a cohort of CHB patients at the hepatology clinics of King Abdul Aziz University Hospital in Jeddah was studied. Methodology: The results of a complete blood count, prothrombin time, liver function test and hepatitis B virus polymerase chain reaction (HBV-PCR) performed over the previous two to five years of follow-up were reviewed. Results of abdominal ultrasound performed within the last year and the data on the treatment type, duration and resistance were also obtained. Results: The majority of the 109 patients studied were Hepatitis B e antigen (HBeAg-negative; 87.2%). Male patients had higher serum ALT values compared to females at follow-up. HBeAg-positive patients had higher HBV-PCR levels at diagnosis compared to HBeAgnegative patients. Patients below 40 years of age had higher HBV-PCR compared to those above 40 years. Ultrasound showed liver cirrhosis in 11% of patients. Cirrhotic patients had higher GGT levels compared to non cirrhotic patients. Drug resistance developed in 25% of the 20 Lamivudine-treated patients. The mean duration of treatment was 2.5 ± .47 years. Conclusion: CHB was predominantly HBeAg negative, with a benign long-term outcome in most patients. Therapy may need to be individualized for patients with high risk of progression.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

Fallatah

Akbar

2010

J Infect Dev Ctries

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“…Previous studies have shown that males have a 1.8 greater likelihood [35] of HBV infection and that HBV occurs at a higher incidence in males than in females [15]. Therefore, studies among blood donors may not accurately reflect the situation in the general community but rather may overrate HBV carrier rate and prevalence.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the year 2007, 9,000 newly diagnosed viral hepatitis cases were reported by the Saudi Ministry of Health, ranking viral hepatitis as the second-most common viral disease after chickenpox [14], with about 50% of the cases were due to HBV and over 30% due to HCV [15]. In Saudi Arabia HIV rates of 1.5 cases per 100,000, Saudis, and 13.2 per 100,000 non-Saudi residents [16], and a prevalence of 0.0% to 0.4% of anti-HTLV-I/II been reported [17,18].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

Almutairi

AlAhmari²,

Al-Zahran³

et al. 2016

J Infect Dev Ctries

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Introduction: Data on blood-borne viral infections in some regions in Saudi Arabia remain scarce. This study investigates the prevalence of serological markers and nucleic acid for blood-borne viruses among blood donors in Al-Baha, Kingdom of Saudi Arabia. Methodology: In this cross-sectional study, 2,807 donors who donated blood between January 2009 and November 2011 were investigated for blood-borne viral serological markers including HBsAg, anti-HBc, anti-HBs, anti-HCV, anti-HIV, and anti-HTLVI/III in addition to viral nucleic acid. Results: All donors were males between 16 to 66 years of age (mean: 31.5 ± 9.3 years). Viral nucleic acid and/or serological markers were detected in a total of 36 (1.3%) donors; of them, 26 (72.2%) had nucleic acid concomitant with serological markers, 6 (16.7%) had only viral nucleic acid, while 4 (11.1%) had only serological markers. Of all donors, 22 (0.8%) had HBsAg, 227 (8.0%) had anti-HBc, 157 (5.0%) had anti-HBs, 2,577 (91.8%) had no HBV markers, 2 (0.07%) had anti-HIV, 1 (0.04%) had anti-HCV, and 1 (0.04%) had anti-HTLVI/II. The donors who were born during HBV vaccination era showed no HBsAg (0.0%; p = 0.052), lower rates of anti-HBc (1.5%; p < 0.001) and antiHBs (0.7%; p < 0.001), while the majority had no HBV markers (98.5%; p < 0.001). Conclusions: Combined viral nucleic acid and serological testing of donated blood enhances blood safety. The absence of HBV markers among donors suggests susceptibility or declined anti-HBs levels. Thus, HBV revaccination or a vaccine boost among adolescents and adults might be indispensable.

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“…Its peaks in March and September. 13 Hepatitis A virus infection is an acute disease and can be cured and all of the transmission of HAV through the fecal-oral route.…”

Section: Methodsmentioning

confidence: 99%

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

Tanadi

Lusida

Joewono

2017

IJTID

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Hepatitis B Virus (HBV) can be transmitted vertically from mother to her baby. Mothers with HBsAg and HBeAg positives have more risk of transmitting HBV to her baby rather than HBsAg positives only. The aim of this study is to determine the proportion of maternal patient with HBsAg and HBeAg positives and their HBsAg positives babies with immunoprophylaxis of HBV immunization. This study was performed by analytical observation using medical records in 2013-2014 at Obstetric and Gyn ecology

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Incidence trends of viral hepatitis A, B, and C seropositivity over eight years of surveillance in Saudi Arabia

Abstract: Despite the declining trend over the eight-year period, viral hepatitis, especially that caused by HBV and HCV, remains a major public health problem in Saudi Arabia, and has probably been underestimated in previous reports. There is a need for more comprehensive prevention strategies.

Cited by 60 publications

References 15 publications

Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

Chronic hepatitis B infection in a hepatology clinic at a university hospital in Jeddah

Prevalence of serological markers and nucleic acid for blood-borne viral infections in blood donors in Al-Baha, Saudi Arabia

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

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