Incidence trends of conjunctival malignant melanoma in Canada

Ghazawi, Feras M.; Darwich, Rami; Le, Michelle; Jfri, Abdulhadi; Rahme, Elham; Burnier, Julia V.; Sasseville, Denis; Burnier, Miguel N; Litvinov, Ivan V.

doi:10.1136/bjophthalmol-2019-313977

Cited by 36 publications

(29 citation statements)

References 19 publications

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“…Incidence and mortality data for oral cavity and oropharyngeal malignancies were extracted from 3 distinct but complementary population-based cancer databases (Canadian Cancer Registry [CCR], Le Registre Québécois du Cancer [LRQC], and Canadian Vital Statistics [CVS]) using the previously reported and established methods. 11 -34…”

Section: Methodsmentioning

confidence: 99%

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Ghazawi

Savin

et al. 2020

J Cutan Med Surg

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Background Oral cavity cancers (OCCs) and oropharyngeal cancers (OPCs) continue to be a major source of morbidity and mortality worldwide requiring the shared effort of numerous specialists. Tobacco and alcohol consumption have long been identified as risk factors for both OCC and OPC. In addition, human papilloma virus (HPV) is gaining its position as the main causal agent for OPC. Objective The objective of this study is to analyze the epidemiology of OCC and OPC in Canada. Methods Data pertaining to the year of diagnosis, the patient’s sex, age at the time of diagnosis, province/territory, city and postal code of oral cavity, and oropharyngeal malignancies diagnosed during 1992-2010 were extracted from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Results In total, 21 685 OCC cases and 15 965 OPC cases were identified from 1992 to 2010. Of those, 84.97% were oral cavity squamous cell carcinomas (SCCs), 88.10% were oropharyngeal SCCs, and both had a significant male predominance. While oral cavity SCC incidence stabilized over the study period, oropharyngeal SCC continued to increase. Oral cavity SCC incidence increased with age, while oropharyngeal SCC incidence peaked in the 50- to 59-year age group. Detailed geographic distribution analysis of patients at the provincial/territorial, city, and postal code levels identified several patient clusters. Conclusions This work highlights important epidemiological differences in trends between oral and oropharyngeal cancers, identifies high-incidence postal codes for each malignancy, and correlates incidence/mortality with known risk factors including alcohol/tobacco use and HPV infections, therefore providing a comprehensive understanding of epidemiology for these cancers in Canada.

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Section: Methodsmentioning

confidence: 99%

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Ghazawi

Savin

et al. 2020

J Cutan Med Surg

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“…The incidence of cutaneous melanoma (CM) has been increasing over the last several decades in the USA, Canada [1][2][3], and European countries [4]. In 2012, ∼232,000 new cases of melanoma and ∼55,000 deaths were registered worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

et al. 2020

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Background: Cutaneous melanoma (CM) incidence has been increasing around the world. The goal of this study is to describe geographic trends in incidence and mortality of CM in Russia between 2001 and 2017. Methods: To achieve this we used geo-informatic technique (mapping) and descriptive statistical analysis. Additionally, we studied the associations between ethnicity, geographic latitude/longitude, and CM incidence/mortality rates. We retrospectively analyzed the data from the Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, for the period of the study. Routine methods of descriptive epidemiology were used to study incidence and mortality rates by age groups, years, and jurisdictions (i.e., Federal Districts and Federal Subjects of Russia). Results: In total, 141,597 patients were diagnosed with melanoma in Russia over the period 2001-2017, of whom 62% were women. The overall agestandardized incidence and mortality rates were 4.27/100,000 and 1.62/100,000, respectively. Geographic mapping revealed north-to-south and east-to-west gradients. As the study was fully descriptive, retrospective, and based on official statistical reports, detailed characteristics of clinical forms, anatomic sites, Breslow depth, and treatments could not be analyzed. Conclusions: This study outlined the burden of melanoma in the Russian Federation, and the trends were similar to those observed in countries with similar latitudes and skin phenotype. The importance of the skin color gradient and recreational/cultural practices were some of the most important risk factors highlighted in this study for the development of melanoma in Russia.

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“…Incidence data were collected from the Canadian Cancer Registry (CCR) and Le Registre Québécois du Cancer (LRQC) databases and mortality data from the Canadian Vital Statistics (CVS), as previously reported. [13][14][15][16][17][18][19][20][21][22][23][24][25][26]…”

Section: Methodsmentioning

confidence: 99%

Penile Invasive Squamous Cell Carcinoma: Analysis of Incidence, Mortality Trends, and Geographic Distribution in Canada

Lagacé

Ghazawi

et al. 2019

J Cutan Med Surg

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Background Penile invasive squamous cell carcinoma (SCC) is a rare disease with several known risk factors. However, few studies have assessed its incidence, mortality, and temporal trends. Objective Our objectives are to analyze the epidemiology of penile SCC in Canada and to examine patient distribution with this cancer across Canada in order to elucidate population risk factors. Methods Three independent cancer registries were used to retrospectively analyze demographic data from Canadian men diagnosed with penile invasive SCC between 1992 and 2010. The Canadian Census of Population was used to calculate incidence and mortality rates at the province and Forward Sortation Area levels. Results The overall age-adjusted incidence rate was 6.08 cases per million males. Four provinces with statistically significantly higher incidence rates were identified. The national crude incidence rates increased linearly between 1992 and 2010, whereas the age-adjusted incidence rates showed no significant increase during this time period. The overall age-adjusted mortality rate was 1.88 deaths per million males per year. The province of Saskatchewan had significantly higher mortality rates. There was no increase in crude or age-adjusted mortality rates between 1992 and 2010. There was a significant positive correlation between incidence rates and obesity, Caucasian ethnicity, and lower socioeconomic status. Conclusion This study was able to establish geographic variation for this malignancy at the provincial level. Although there are many established risk factors for penile SCC, our results suggest that the increase in crude incidence rates observed is largely due to the aging population.

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Incidence trends of conjunctival malignant melanoma in Canada

Cited by 36 publications

References 19 publications

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Epidemiology and Patient Distribution of Oral Cavity and Oropharyngeal SCC in Canada

Geographic Variations in Cutaneous Melanoma Distribution in the Russian Federation

Penile Invasive Squamous Cell Carcinoma: Analysis of Incidence, Mortality Trends, and Geographic Distribution in Canada

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