Incidence Trends of Breast Cancer Molecular Subtypes by Age and Race/Ethnicity in the US From 2010 to 2016

Acheampong, Teofilia; Kehm, Rebecca D.; Terry, Mary Beth; Argov, Erica J. Lee; Tehranifar, Parisa

doi:10.1001/jamanetworkopen.2020.13226

Cited by 96 publications

(77 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The observation regarding SLC16A3 is notable because high expression worsens (or tends to worsen) patient prognosis in the other breast cancer molecular subtypes ( Figure 10—figure supplement 2C and E–G ). Luminal A breast cancer comprises 50–70% of breast cancer cases in the United States and Europe ( Kulkarni et al, 2019 ; Acheampong et al, 2020 ; Valla et al, 2016 ) and is clinically interesting because distant metastasis occurs throughout follow-up for as long as 25 years after initial diagnosis ( Yu et al, 2019 ). This is different from, for instance, luminal B breast cancer where the risk of metastasis is high the first 5 years after diagnosis but then markedly declines ( Yu et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Toft

Axelsen

Pedersen

et al. 2021

eLife

View full text Add to dashboard Cite

Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity and hence the acid load on cancer cells. We hypothesized that acid-base transporters and intracellular pH (pHi) dynamics contribute inter-individual variability in breast cancer aggressiveness and prognosis. We show that Na+,HCO3--cotransport and Na+/H+-exchange dominate cellular net acid extrusion in human breast carcinomas. Na+/H+-exchange elevates pHi preferentially in estrogen receptor-negative breast carcinomas, whereas Na+,HCO3--cotransport raises pHi more in invasive lobular than ductal breast carcinomas and in higher malignancy grade breast cancer. HER2-positive breast carcinomas have elevated protein expression of Na+/H+-exchanger NHE1/SLC9A1 and Na+,HCO3--cotransporter NBCn1/SLC4A7. Increased dependency on Na+,HCO3--cotransport associates with severe breast cancer: enlarged CO2/HCO3--dependent rises in pHi predict accelerated cell proliferation; whereas enhanced CO2/HCO3--dependent net acid extrusion, elevated NBCn1 protein expression, and reduced NHE1 protein expression predict lymph node metastasis. Accordingly, we observe reduced survival for patients suffering from Luminal A or Basal-like/triple-negative breast cancer with high SLC4A7 and/or low SLC9A1 mRNA expression. We conclude that the molecular mechanisms of acid-base regulation depend on clinicopathological characteristics of breast cancer patients. NBCn1 expression and dependency on Na+,HCO3--cotransport for pHi regulation, measured in biopsies of human primary breast carcinomas, independently predict proliferative activity, lymph node metastasis, and patient survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Toft

Axelsen

Pedersen

et al. 2021

eLife

View full text Add to dashboard Cite

show abstract

“…Breast cancer is the most common cancer and the leading cause of cancer deaths in women globally and China (1,2). According to molecular subtype, breast cancer is divided into Luminal A, Luminal B, HER2-enriched, and triple-negative subtypes, among which the luminal subtype, accounting for 65% to 70% of the cases, has the highest proportion (3). In recent years, next-generation sequencing (NGS) has accelerated the systematic characterization of the genomic landscape of breast cancer, which contributed to our current understanding of the unique and shared genomic features of the four breast cancer molecular subtypes (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Frequently Mutated Cancer Genes and Tumor Mutation Burden in Chinese Breast Cancer

et al. 2021

View full text Add to dashboard Cite

ObjectivesVarious genomic alterations and genomic signatures, including ERBB2 amplification, mutations in PIK3CA, AKT1, and ESR1, and tumor mutational burden (TMB), have become important biomarkers for treatment selection in breast cancer (BC). This study aimed to investigate the mutational features of Chinese early-stage BC patients.MethodsTumors and matched blood samples collected from 589 Chinese patients with early-stage BC were sequenced using a commercial gene panel consisting of 520 cancer-related genes to analyze all types of genomic alterations and estimate the TMB status.ResultsA total of 18 genes were found to be more frequently mutated (P<0.05) or amplified (P<0.05) in stage T3–4 tumors as compared with T1–2 tumors. A total of 18 genes were found to be differentially mutated (P<0.05) or amplified (P<0.05) in patients with lymph node metastasis than those without lymph node metastasis. Younger patients (≤35 years) were more frequently identified with mutations or gene amplifications in eleven genes (P<0.05). TMB >10mutations/Mb were found in 5.7% of our cohort. Although the TMB was similar for various molecular subtypes between our cohort and the BC cohort of The Cancer Genome Atlas (TCGA) study, the TMB were statistically different for HR+/HER-, HR+/HER2+, and triple-negative subtypes between our cohort and African Americans in the TCGA study. As compared to the TCGA BC cohort, our cohort had a much earlier median age of diagnosis (48 vs. 58 years, P<0.001), and had significantly lower frequency of triple-negative subtype (11.5% vs. 18.4%, P<0.001) and invasive lobular BC (2.4% vs. 19.0%, P<0.001). Further subgroup analyses revealed that mutation rates in various genes including TP53, ERBB2, and PIK3CA were distinct for patients who were younger (≤35 years), had triple-negative or invasive lobular BC in our cohort than in the TCGA cohort.ConclusionsThis study revealed distinct mutational features of various molecular subtypes of early-stage BC among Chinese patients. Moreover, we provide new insights into the differences in early-stage BC between the East and West.

show abstract

“…Breast cancer is known to have a peak of incidence in the 6th decade of life. Moreover, hormonal receptor positive breast cancers, classified as Luminal A or Luminal B, according to the St. Gallen definition [ 8 , 9 ], are the most frequent cancer types encountered in elderly women [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

Santandrea

Bellarosa

Gibertoni

et al. 2021

JPM

View full text Add to dashboard Cite

Normal breast tissue undergoes great variations during a woman’s life as a consequence of the different hormonal stimulation. The purpose of the present study was to examine the hormonal receptor expression variations according to age, menstrual cycle, menopausal state and body mass index. To this purpose, 49 tissue samples of normal breast tissue, obtained during surgery performed for benign and malignant conditions, were immunostained with Estrogen (ER), Progesterone (PR) and Androgen receptors (AR). In addition, Ki67 and Gross Cystic Disease Fluid Protein were studied. The data obtained revealed a great variability of hormone receptor expression. ER and AR generally increased in older and post-menopausal women, while young women presented a higher proliferative rate, evaluated with Ki67. PR increase was observed in women with BMI higher than 25. The different hormonal receptor expression could favor the development of breast cancer.

show abstract

Incidence Trends of Breast Cancer Molecular Subtypes by Age and Race/Ethnicity in the US From 2010 to 2016

Cited by 96 publications

References 19 publications

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Characterization of Frequently Mutated Cancer Genes and Tumor Mutation Burden in Chinese Breast Cancer

Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

Contact Info

Product

Resources

About