Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958

Rockberg, Julia; Bach, Bruce Allen; Amelio, Justyna; Hernandez, Rohini K.; Sobocki, Patrik; Engellau, Jacob; Bauer, Henrik C. F.; Liede, Alexander

doi:10.2106/jbjs.o.00156

Cited by 46 publications

(41 citation statements)

References 40 publications

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“…Giant cell tumors of bone (GCTBs) is a benign but invasive primary bone tumor, accounting for 5% of primary bone tumors. 1,2 Approximately 50% of giant cell tumors occur around the knee joint. 3 At present, the main surgical treatment options are tumor resection and intralesional curettage.…”

Section: Introductionmentioning

confidence: 99%

Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases

Tang

Moro

Feng

et al. 2019

Journal of Surgical Oncology

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Purpose The epidemiology and clinicopathology of aneurysmal bone cysts (ABCs) secondary to giant cell tumors of bone (GCTBs) have been well documented in the previous literature. However, reports on whether secondary ABCs could affect the postoperative recurrence of GCTBs are rare. This study analyzed the effects of secondary ABCs and other relevant clinical factors on the postoperative recurrence of GCTBs of the extremities. Methods We retrospectively analyzed 256 cases of GCTBs of the extremities that were treated surgically at our institution. Among them, there were 60 patients diagnosed with GCTBs combined with secondary ABCs and 196 patients diagnosed with simple GCTBs. Intralesional curettage and tumor resection were performed in 136 and 120 cases, respectively. Univariate analysis, Kaplan‐Meier survival analysis, and multivariate regression analysis were used to assess the factors for postoperative recurrence. The follow‐up period was at least 24 months. Results The total postoperative recurrence rate was 32%. The recurrence rate in the secondary ABCs group was significantly higher than that in the simple GCTBs group (53.3% vs 25.5%, P < 0.05). Curettage was associated with a higher recurrence rate than tumor resection (42.5% vs 20%, P < 0.05). Kaplan‐Meier survival analysis showed that patients with GCTBs combined with secondary ABCs and who were treated by intralesional curettage had a decreased disease‐free survival rate. The hazard ratio was 2.18 (95% confidence interval [CI], 1.15‐4.13) for the group of GCTB combined with ABCs ( P = 0.01) and 1.97 (95% CI, 1.22‐7.50) for the curettage group ( P = 0.01), respectively. Multivariate regression analysis revealed that the presence of secondary ABCs and curettage were independent factors for recurrence of GCTBs. Conclusion According to the results of this study, the presence of secondary ABCs is a potential risk factor for postoperative relapse of GCTBs.

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Section: Introductionmentioning

confidence: 99%

Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases

Tang

Moro

Feng

et al. 2019

Journal of Surgical Oncology

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“…GCT is a kind of locally aggressive neoplasm occurring most often in young adults with high recurrence rate and occasional metastasis. 6 GCTs typically occur at the meta-epiphyseal region of long bones (75%-90%) with about 2% of which originate in the head and neck region. [7][8][9] GCTs in the head neck region most often occur in the sphenoid, temporal, or ethmoid bones but very rarely in the larynx.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity

Zhang

Zhu

et al. 2018

Diagnostic Cytopathology

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Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. The typical cytological feature of GCT on FNA smears is highly cellular dual cell pattern consisting of mononuclear stromal cells and multinucleate osteoclast-like giant cells. By performing FNA of the left lobe of thyroid and clinico-radiological evaluation, we were able to diagnose a mass in a 40-year-old male patient as GCT based on cytological specimen. To the best of our knowledge, this is the first case that a GCT is identified in the thyroid gland by FNA initially.

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“…Giant cell tumor of bone or soft tissue is a neoplasm with potential malignancy, which accounts for ∼5% of all primary bone tumors 1 . It mainly occurs in the epiphyseal and metaphyseal regions of long bones, while sometimes in the vertebras of spine 2 .…”

Section: Introductionmentioning

confidence: 99%

Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy

Chen

Yan

Tirumala

2020

Journal Orthopaedic Research

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Malignant giant cell tumor of bone or soft tissue (MGCTBS) is one of the malignant tumors associated with poor prognosis. However, it remains controversial whether the combined treatment of both surgery and radiotherapy (surgery + RT) leads to better survival outcomes than surgical treatment alone (surgery alone) does for patients diagnosed with MGCTBS. We compared the two treatment strategies using the data provided by Surveillance, Epidemiology, and End Results (SEER) program. About 357 patients with MGCTBS who received either surgery + RT or surgery alone between 1975 and 2016 in the USA were identified and then matched based on their propensity scores estimated using the patients' baseline characteristics. We also performed a subgroup analysis for patients with high‐grade and regional/distant tumor extension. Unadjusted Kaplan‐Meier curves suggested that the surgery alone group had a better 10‐year survival profile than the surgery + RT group. After propensity score matching, there was no statistical difference between the two treatment groups with respect to the 10‐year cancer‐specific survival and overall survival distributions. A subsequent subgroup analysis demonstrated that the surgery alone group has a similar 10‐year survival comparing with the surgery + RT group for patients with high‐grade and regional/distant tumor extension. The results of our study suggest that RT should not be recommended as a regular therapeutic method for MGCTBS, even for patients with high‐grade histology and distant metastasis Clinical Significance: This study may provide better decision making for surgeons dealing with malignant giant cell tumor of bone or soft tissue. Type of study: Observation study. Level of evidence: Level III.

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Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958

Cited by 46 publications

References 40 publications

Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases

Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases

Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity

Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy

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