Incidence study of Guillain-Barré syndrome in the province of Ferrara, Northern Italy, between 2003 and 2017. A 40-year follow-up

Granieri, Enrico; Andreasi, Nico Golfrè; Martin, Paolo De; Govoni, Vittorio; Castellazzi, Massimiliano; Cesnik, Carlos E. S.; Pugliatti, Maura; Casetta, Ilaria

doi:10.1007/s10072-018-3688-4

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…The axonal subtype is slightly over-represented in our cohort, considering that for European countries the frequencies of axonal GBS had been established between 6 and 17% ( 31 ). The number of axonal subtypes was in line with that reported in a cohort of Rome ( 32 ), higher and lower than those reported in the populations of Ferrara and La Spezia, respectively ( 11 , 12 ). The different geographical distribution of GBS types may lead to considering the role of a possible environmental factor.…”

Section: Discussionsupporting

confidence: 88%

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Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience

et al. 2022

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BackgroundClinical presentation, electrophysiological subtype, and outcome of the Guillain–Barre' Syndrome (GBS) may differ between patients from different geographical regions. This study aims to assess clinical–neurophysiological features of an adult, Italian GBS cohort over 11 years.MethodsRetrospective (from 1 January 2011 to 31 December 2021) analysis was carried out on patients admitted to the Siena University Hospital who fulfilled the GBS diagnostic criteria. Demographic data, clinical characteristics, treatment, need of mechanical ventilation (MV), laboratory and electrophysiological tests, preceding infections/vaccination/other conditions, and comorbidities were collected for each patient.ResultsA total of 84 patients (51 men, median age of 61 years), were identified. GBS subtype was classified as acute inflammatory demyelinating polyneuropathy (AIDP) in the 66.6% of patients, acute motor/sensory axonal neuropathy (AMAN/AMSAN) in 20.2%, and the Miller Fisher syndrome in 5 (5.9%). Flu syndrome and gastrointestinal infection were the most common preceding conditions. In total, five (5.9%) subjects had concomitant cytomegalovirus (CMV) infection. Cranial nerve involvement occurred in 34.5% of subjects. Differences between the axonal and AIDP forms of GBS concerned the presence of anti-ganglioside antibodies. In total, seven (8.33%) patients required MV.DiscussionThe epidemiological and clinical characteristics of GBS in different countries are constantly evolving, especially in relation to environmental changes. This study provides updated clinical-epidemiological information in an Italian cohort.

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Section: Discussionsupporting

confidence: 88%

“…Epidemiological differences are also likely to exist within countries. For example, although in Italy axonal forms account for more than 15% of cases ( 2 ), the reported local incidence varies between 35% ( 11 ) and 4.11% ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience

et al. 2022

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“…We reported higher rates of mechanical ventilation (27%) compared to previous studies (9%-14%) 14,27,34,35 and the reasons for this are unclear. Intensive Care Units (ICUs) are located at all hospitals in the southern region of Uruguay and access to them is generally good.…”

Section: F I G U R E 4 Seasonal Incidence Rates and 95% Confidence In...contrasting

confidence: 79%

Incidence of Guillain‐Barré syndrome in an Uruguayan population. A prospective cohort study

Chiesa

Decima

Bertinat

et al. 2021

J Peripheral Nervous Sys

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Guillain-Barre syndrome (GBS) is an acute autoimmune peripheral inflammatory neuropathy and the most frequent cause of non-poliovirus acute flaccid paralysis worldwide. Background annual GBS incidence rates (IRs) in Latin America (LA) varies from 0.40 to 2.12/100000 persons per year. We performed a prospective populationbased epidemiological study to determine the incidence and clinical profile of GBS in the most densely populated regions in Uruguay. The incidence of GBS in the population living in Montevideo and Canelones was studied in the period between June 01, 2018 and May 31, 2020. Patients older than 16 years of age diagnosed with GBS were prospectively enrolled. The mean global annual IR in the Uruguayan population was 1.7/100000 persons (95% CI 1.25-2.25). The highest rate was observed in the 65 to 74 age group among men (5.25/100000 per year) and in the 55 to 64 age group among women (2/100.000 per year). The mean age was 53.9 ± 19.5, years, without difference by sex (53.5 women, 54.5 men). The in-hospital mortality rate was 5.8%. A total of 51 patients were diagnosed with GBS: 42 (82%) had typical GBS, 5 (10%) Miller-Fisher syndrome (MFS), 3 (7%) a bilateral facial nerve palsy, 1 patient had a GBS-MFS overlap (2.3%). This is the first population-based GBS incidence study in LA using a prospective design. Our IR can be a useful tool in establishing the background rate to examine future disease trends caused by the introduction of new viruses or vaccines in Uruguay.

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“…The patterns observed in our study were generally comparable with those of previous reports. 2 3 29 30 32 33 34 Stratification by age and sex and standardisation are likely to be useful analytical strategies to reduce confounding when incidence rates are compared across populations. The observed magnitude of heterogeneity across sources within age and sex subgroups, however, suggests that residual patient level differences will remain, including differences in the distributions of other risk factors, such as comorbidities and medication use.…”

Section: Discussionmentioning

confidence: 99%

Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study

Ostropolets

Makadia

et al. 2021

BMJ

137

130

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Objective To quantify the background incidence rates of 15 prespecified adverse events of special interest (AESIs) associated with covid-19 vaccines. Design Multinational network cohort study. Setting Electronic health records and health claims data from eight countries: Australia, France, Germany, Japan, the Netherlands, Spain, the United Kingdom, and the United States, mapped to a common data model. Participants 126 661 070 people observed for at least 365 days before 1 January 2017, 2018, or 2019 from 13 databases. Main outcome measures Events of interests were 15 prespecified AESIs (non-haemorrhagic and haemorrhagic stroke, acute myocardial infarction, deep vein thrombosis, pulmonary embolism, anaphylaxis, Bell’s palsy, myocarditis or pericarditis, narcolepsy, appendicitis, immune thrombocytopenia, disseminated intravascular coagulation, encephalomyelitis (including acute disseminated encephalomyelitis), Guillain-Barré syndrome, and transverse myelitis). Incidence rates of AESIs were stratified by age, sex, and database. Rates were pooled across databases using random effects meta-analyses and classified according to the frequency categories of the Council for International Organizations of Medical Sciences. Results Background rates varied greatly between databases. Deep vein thrombosis ranged from 387 (95% confidence interval 370 to 404) per 100 000 person years in UK CPRD GOLD data to 1443 (1416 to 1470) per 100 000 person years in US IBM MarketScan Multi-State Medicaid data among women aged 65 to 74 years. Some AESIs increased with age. For example, myocardial infarction rates in men increased from 28 (27 to 29) per 100 000 person years among those aged 18-34 years to 1400 (1374 to 1427) per 100 000 person years in those older than 85 years in US Optum electronic health record data. Other AESIs were more common in young people. For example, rates of anaphylaxis among boys and men were 78 (75 to 80) per 100 000 person years in those aged 6-17 years and 8 (6 to 10) per 100 000 person years in those older than 85 years in Optum electronic health record data. Meta-analytic estimates of AESI rates were classified according to age and sex. Conclusion This study found large variations in the observed rates of AESIs by age group and sex, showing the need for stratification or standardisation before using background rates for safety surveillance. Considerable population level heterogeneity in AESI rates was found between databases.

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Incidence study of Guillain-Barré syndrome in the province of Ferrara, Northern Italy, between 2003 and 2017. A 40-year follow-up

Cited by 12 publications

References 33 publications

Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience

Clinical Features and Outcome of the Guillain–Barre Syndrome: A Single-Center 11-Year Experience

Incidence of Guillain‐Barré syndrome in an Uruguayan population. A prospective cohort study

Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study

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