Incidence, risk factors and prognosis of acute kidney injury after transcatheter aortic valve implantation

Abstract

AKI developed in 28.8% of patients after TAVI and was associated with procedural technique and transfusion requirement, and an increased LOS and mortality. However, most patients achieved a significant and sustained improvement in eGFR.

Incidence, risk factors and prognostic impact of acute kidney injury on 30-day mortality after transcatheter aortic valve implantation

“…[22] Furthermore, RBC transfusion has been associated with an increased risk of AKI after TAVI in several reports. [4,5,8,11,12] In this study, the amount of periprocedural RBC transfusion was found to be higher in the patients with AKI, although it was not statistically significant (OR: 2.13; 95% CI: 0.83-.48, p= 0.11). In several studies, it has shown that the number of blood transfusions is an independent predictor of AKI after TAVI.…”

“…However, they observed an increase in the eGFR in 36.3% of the patients with CKD following the intervention. In another study, Kong et al [12] reported a higher incidence of AKI in the patients with CKD, although it was not statistically significant (p= 0.07). In the aforementioned study, renal functions of the patients who did not experience AKI were significantly improved immediately after TAVI and this improvement sustained up to 12 months after the procedure.…”

“…This was attributed to the possible reversion of pathophysiological processes in type 2 cardiorenal syndrome (CRS) which describes the complex interplay between the heart and kidneys where acute or chronic dysfunction in one organ initiates and perpetuates the combined disorder of the two organs through a complex combination of hemodynamic and neurohormonal feedback mechanisms. [12] Type 2 CRS is characterized by chronic cardiac dysfunction, causing progressive CKD. [22] Furthermore, RBC transfusion has been associated with an increased risk of AKI after TAVI in several reports.…”

“…In several studies, it has shown that the number of blood transfusions is an independent predictor of AKI after TAVI. [4,5,8,11,12] Complications causing bleeding after the procedure occur very frequently, which results in a higher incidence of blood transfusions as well as a higher incidence of renal hypoperfusion. Both these factors have been shown to be associated with AKI.…”

“…Several studies have investigated the incidence and predictors of AKI after TAVI. [4][5][6][7][8][9][10][11][12][13][14] Previous studies have shown that AKI occurs in about 11.7 to 41.7% of patients undergoing TAVI and has been associated with 2-to 5.47-fold increased risk of mortality. [5][6][7][8][9][10] In the present study, we aimed to determine the incidence, predictors, and prognostic impact of AKI on 30-day mortality following TAVI.…”