Incidence, Risk Factors, and Outcomes Associated With In-Hospital Acute Myocardial Infarction

Bradley, Steven M; Borgerding, Joleen; Wood, G. Blake; Maynard, Charles; Fihn, Stephan D.

doi:10.1001/jamanetworkopen.2018.7348

Cited by 37 publications

(33 citation statements)

References 46 publications

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“…One such recent study focused on the incidence, risk factors and mortality outcomes related to IH-AMI. 5 Regardless of the setting of onset of AMI, evidence-based (E-B) secondary prevention strategies are based on changes in lifestyle and E-B drug therapy. With this regard, international guidelines recommend the combined use of drugs belonging to different anatomical therapeutic chemical (ATC) groups including antithrombotic agents, β-blockers, ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs) and statins.…”

Section: Introductionmentioning

confidence: 99%

In-hospital myocardial infarction and adherence to evidence-based drug therapies: a real-world evaluation

Soldati¹,

Martino²,

Castagno³

et al. 2021

BMJ Open

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ObjectivesThis study aimed to measure adherence to chronic polytherapy following an acute myocardial infarction (AMI) and to find out associations between adherence and the setting of AMI onset (in vs out of hospital) as well as other determinants.DesignRetrospective follow-up study.SettingPopulation living in the Lazio Region, Italy.ParticipantsThis study included 25 779 hospitalised patients with a first diagnosis of AMI in 2012–2016, after the exclusion of those with hospital admission for AMI or related causes in the previous 5 years.Primary and secondary outcome measuresPatients were classified as in-hospital AMI (IH-AMI) or out of hospital AMI (OH-AMI) according to present-on-admission codes. Adherence was measured based on prescription claims during a 6-month follow-up after hospital discharge, using medication possession ratio (MPR). Adherence to chronic polytherapy was defined as MPR ≥75% to at least 3 of the following medications: antithrombotics, betablockers, ACE inhibitors/angiotensin receptor blockers and statins.ResultsAmong the entire cohort, 1 044 (4%) patients suffered IH-AMI. Overall, 15 440 (60%) patients were deemed adherent to chronic polytherapy. Female gender, older age, mental disorders, renal disease, asthma and ongoing concomitant treatments were factors associated with poor adherence. By contrast, patients with more severe AMI and those already taking evidence-based (E-B) drugs were more likely to be adherent. A strong association between the setting of AMI onset and adherence was observed: IH-AMI patients were 46% less likely to be adherent to E-B medications during their 6-month follow-up as compared with OH-AMI patients (OR 0.54; 95% CI 0.47 to 0.62; p<0.001).ConclusionPharmacotherapy is not consistent with clinical guidelines, especially for IH-AMI patients. Our findings provide evidence on a previously unidentified groups of patients at risk for poor adherence, who might benefit from greater medical attention and dedicated healthcare interventions.

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Section: Introductionmentioning

confidence: 99%

In-hospital myocardial infarction and adherence to evidence-based drug therapies: a real-world evaluation

Soldati¹,

Martino²,

Castagno³

et al. 2021

BMJ Open

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“…Acute myocardial infarction (AMI) is a serious cardiovascular disease and has high mortality and disability rates . The sudden onset of AMI poses a great threat to human health, so how to prevent and diagnose it early has always been a research hotspot.…”

Section: Introductionmentioning

confidence: 99%

Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR‐125b/SFRP5 pathway

Sun

Zhao

et al. 2020

Cell Biochemistry & Function

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Funding informationThis work was supported by the young teachers program of Beijing university of Chinese medicine (2018-JYBZZ-JS094) and the scientific research project of Sichuan health committee (19PJ214).Current studies have shown that circular RNAs (circRNAs) and microRNAs (miRNAs) are closely related in acute myocardial infarction (AMI). Previous studies have shown that miR-125b promotes fibrosis and up-regulates in cardiac fibroblasts (CFs), and further experiments showed that circ_LAS1L had multiple binding sites of miR-125b, and their expression was inversely related in AMI patients and CFs. RNA immunoprecipitation (RIP), pull down, and dual luciferase reporter gene assay all confirmed that miR-125b directly bound to circ_LAS1L. Circ_LAS1L overexpression promoted the expression of downstream target gene secreted frizzled-related protein 5 (SFRP5), inhibited the expression of alpha-SMA, collagen I, and collagen III, inhibited CF proliferation and migration, and promoted apoptosis. When cotransfected with circ_LAS1L overexpression vector and miR-125b mimics, the above gene expression and CF biological behaviours did not change significantly. But when cotransfected with circ_LAS1L overexpression vector and SFRP5 siRNA, SFRP5 expression was still down-regulated, the expression of alpha-SMA, collagen I, and collagen III was up-regulated, and the proliferation and migration of CFs were increased. Therefore, circ_LAS1L inhibits the activity of miR-125b by adsorbing it, thus promoting the expression of SFRP5 and then regulating the biological characteristics of CFs. These findings may provide an important experimental basis for the regulation of myocardial fibrosis after myocardial infarction.Significance of the study: Studies have shown that circular RNAs (circRNAs) play important roles in cardiovascular diseases, but there are few studies on their roles in the process of myocardial fibrosis. In this study, we found that circ_LAS1L was down-regulated in acute myocardial infarction (AMI) patients and cardiac fibroblasts (CFs), and could bind directly to miR-125b, thereby promoting the expression of downstream target gene secreted frizzled-related protein 5 (SFRP5), ultimately inhibiting the activation, proliferation and migration of CF, and promoting apoptosis. This suggests that circ_LAS1L/miR-125b/SFRP5 pathway can regulate the biological function of CF and may play an important role in the process of myocardial fibrosis, thus providing an important theoretical basis for the regulation of myocardial fibrosis after myocardial infarction. K E Y W O R D S cardiac fibroblast, circRNA, miR-125b, myocardial infarction, SFRP5 Li-ye Sun and Jin-chao Zhao contributed equally to this work.

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“…It is progressively perceived that AMI additionally happens among patients previously hospitalized for different conditions. 35 All inclusive, stroke is the second driving reason for death and third driving reason for disability.1 More than 74% of the weight of stroke has been ascribed to smoking, less than stellar eating routine, and low physical movement, while over 72% has been credited to metabolic hazard factors (high plasma glucose, elevated cholesterol, hypertension, overweight and heftiness, and kidney ailment). 37 Myocardial areas of localized necrosis (MIs) are among the main sources of dismalness and mortality in the United States and lead to >$11 billion in yearly hospitalization costs.…”

Section: Prevalence and Economic Burden Of Cardiac Diseasesmentioning

confidence: 99%

Natural Foods and Indian herbs of cardiovascular interest

Mohiuddin¹

2019

PPIJ

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Since the start of human development, herbs have been an essential piece of society, esteemed for both their culinary and medicinal properties. Cardiovascular malady is the main executioner in the United States. Diet and way of life assume an imperative job in avoiding and switching heart infection, and certain herbs and supplements can help in bringing down hazard for heart ailment and treat heart conditions. Contrasted and customary prescriptions, herbal drugs don't require clinical investigations previously their showcasing or formal endorsement from administrative organizations, and thus their viability and wellbeing are once in a while demonstrated. Herbal medications have been utilized in patients with congestive heart disappointment, systolic hypertension, angina pectoris, atherosclerosis, cerebral inadequacy, venous deficiency, and arrhythmia, CHF, since hundreds of years. Be that as it may, numerous herbal cures utilized today have not experienced cautious logical appraisal, and some can possibly make genuine lethal impacts and real medication tranquilize cooperation's. In spite of the greater part of these herbs demonstrating an impact on organic components identified with the cardiovascular system, information on their clinical impacts are inadequate. Conceivably applicable reactions, including expanded danger of medication connections, are portrayed, and the likelihood of tainting or substitution with different meds speaks to a worry. Doctors ought to dependably evaluate the utilization of herbal meds with patients and talk about the conceivable advantages and symptoms with them. Multidisciplinary explore is as yet required to misuse the tremendous capability of these plants. Potential synergistic and unfriendly reactions of herb-medicate communications additionally should be considered. These methodologies will help in setting up them as solutions for cardiovascular sicknesses and incorporating them in the standard of healthcare system. In spite of the fact that it has for quite some time been demonstrated that nutrient D, ascorbic acid, and nutrient B12 are the way to treating unending ailments, including CVDs. Various regular carotenoids are available in new foods grown from the ground, and some have been concentrated widely in the counteractive action of coronary heart illness (CHD).

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Incidence, Risk Factors, and Outcomes Associated With In-Hospital Acute Myocardial Infarction

Cited by 37 publications

References 46 publications

In-hospital myocardial infarction and adherence to evidence-based drug therapies: a real-world evaluation

In-hospital myocardial infarction and adherence to evidence-based drug therapies: a real-world evaluation

Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR‐125b/SFRP5 pathway

Natural Foods and Indian herbs of cardiovascular interest

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