Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible
            <i>Staphylococcus aureus</i>
            Infections in Auckland, New Zealand

Muttaiyah, Sharmini; Coombs, Geoffrey W.; Pandey, SK; Reed, Peter; Ritchie, Stephen; Lennon, Diana; Roberts, Stephen A.

doi:10.1128/jcm.00911-10

Cited by 53 publications

(64 citation statements)

References 25 publications

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“…In support of this view are reports that PVL is less likely to be present in blood culture isolates than isolates obtained from aggressive skin infections or necrotizing pneumonia [26,29]. Our data would fit this model but suggest that the presence of PVL is responsible for this independently of the methicillin resistance-encoding mecA gene.…”

Section: Discussionsupporting

confidence: 80%

“…The association between PVL and young age has also been noted by other investigators [29,31,37]. Possible explanations include age-related acquisition of PVL-specific immunity.…”

Section: Discussionsupporting

confidence: 74%

“…Furthermore, it was the presence of PVL that correlated with a perceived need to undertake incision and drainage, not the detection of MRSA per se, as also reported in studies from Spain, New Zealand, Sweden and France [27,[29][30][31][32].…”

Section: Discussionmentioning

confidence: 61%

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Community-onsetStaphylococcus aureusinfections presenting to general practices in South-eastern Australia

et al. 2013

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SUMMARYCommunity-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P = 0·005) in younger patients (23 vs. 52 years, P < 0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.

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Section: Discussionsupporting

confidence: 80%

“…The association between PVL and young age has also been noted by other investigators [29,31,37]. Possible explanations include age-related acquisition of PVL-specific immunity.…”

Section: Discussionsupporting

confidence: 74%

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Community-onsetStaphylococcus aureusinfections presenting to general practices in South-eastern Australia

et al. 2013

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“…Many CA-MRSA strains carry PVL genes, whereas their frequency in MSSA and dominant HA-MRSA clones is much lower [15]. However, a few studies on PVL-positive MSSA have been published [154][155][156][157].…”

Section: Paper IImentioning

confidence: 99%

Epidemiological and molecular biological studies of multi-resistant methicillin-susceptible Staphylococcus aureus

Lindqvist¹

2014

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Antibiotic resistance is increasingly recognised as a major problem and threat. During the last decades Gram-positive bacteria in general, and methicillin-resistant Staphylococcus aureus (MRSA) in particular, have been in focus both concerning matters of antibiotic resistance and as pathogens causing health care-associated (nosocomial) infections. In contrast to MRSA, studies on clonal distribution of methicillin-susceptible S. aureus (MSSA) are scarce.However, interest in MSSA has increased since it was shown that MRSA emerges from susceptible backgrounds by acquisition of a staphylococcal cassette chromosome element, carrying the mecA gene encoding methicillin-resistance (SCCmec).In an outbreak investigation of MRSA in Östergötland County, Sweden, in 2005, a high incidence of MSSA isolates with concomitant resistance to erythromycin, clindamycin and tobramycin (ECT-R) was detected. Analysis showed that 91 % of the investigated isolates were genetically related (clonal). The ECT-R clone was divided into four different but closely related patterns with pulsed-field gel electrophoresis (PFGE), and was designated spa type t002. Whole genome sequencing revealed that the ECT-R clone carried a pseudo-SCC element estimated to be 12 kb in size, showing a resemblance of more than 99 % with the SCCmec type II element of MRSA strain N315 (New York/Japan clone). This suggested a probable derivation from a highly successful MRSA strain, which had partially excised its SCCmec. The clonal outbreak was concentrated in eight hospital departments and two primary care centres, all located in the city of Linköping. Despite a high exchange of patients with the hospitals in the neighbouring counties in southeast Sweden (Jönköping-and Kalmar County), the ECT-R clone seemed to be limited to Östergötland County. However, a tobramycin-resistant clone predominated by isolates of spa type t084 was found in all three counties in southeast Sweden, and in particular among newborns, suggesting inter-hospital transmission.The ECT-R clone has survived as an abundant MSSA clone for a decade in Östergötland County, which indicates an insufficiency in the maintenance of basic hygiene guidelines, and that the clone probably possesses mechanisms of virulence and transmission that are yet to be discovered. Sammanfattning på svenska

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“…Este factor de virulencia ha sido ampliamente descrito en aislados resistentes a meticilina, pero su rol en infecciones causadas por SASM se ha estudiado de forma reciente en distintas latitudes 31,37,38 . Así, hay reportes de SASM portadores de luk-PV, tanto a nivel internacional como regional.…”

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Staphylococcus aureus adquiridos en la comunidad: caracterización clínica, fenotípica y genotípica de aislados en niños paraguayos

Guillén

Carpinelli

Rodríguez

et al. 2016

Rev. chil. infectol.

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Incidence, Risk Factors, and Outcomes of Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus Infections in Auckland, New Zealand

Abstract: Panton-Valentine leukocidin (PVL) has been linked to invasive community-acquired methicillin-resistant

Cited by 53 publications

References 25 publications

Community-onsetStaphylococcus aureusinfections presenting to general practices in South-eastern Australia

Community-onsetStaphylococcus aureusinfections presenting to general practices in South-eastern Australia

Epidemiological and molecular biological studies of multi-resistant methicillin-susceptible Staphylococcus aureus

Staphylococcus aureus adquiridos en la comunidad: caracterización clínica, fenotípica y genotípica de aislados en niños paraguayos

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