Introduction/Objective. Acute kidney injury (AKI) is a highly prevalent
complication among the critically ill individuals who are admitted to the
intensive care unit (ICU). This study deals with identifying the frequency
and predictors of the lack of renal function recovery in non-renal functions
among critically ill patients requiring dialysis for AKI (AKI-D). Methods.
The study included 440 ICU patients from the University Clinical Center of
Vojvodina in the period from 2014 to 2018. The patients required Continuous
Renal Replacement Therapy (CRRT). In this study, we analyzed various factors
including demographic features, clinical characteristics, laboratory
parameters, co-morbidities, as well as the need for vasopressor therapy and
mechanical ventilation on the day when AKI was confirmed. Additionally, we
examined the different modalities of CRRT, which were used. Results. A
retrospective analysis of the results included discovered that out of 440
patients with AKI-D, 242 (55%), average age 63.14, did not recover renal
function. Significant predictors of renal function non-recovery in
critically ill patients with AKI-D were: the patients age over 65 (p =
0.044), starting time of CRRT (p = 0.043), mechanical ventilation (p =
0.044) and previous kidney disease (p = 0.005). Significant predictors of
renal function non-recovery in critically ill septic patients with AKI-D
were: the patients age over 65 (p = 0.002), diabetes mellitus (p = 0.023),
previous kidney disease (p = 0.045), CRP values < 100 mg/l (p = 0.033) and
procalcitonin (p = 0.010), while in non-septic patients, the significant
predictors of renal function non-recovery includes previous kidney disease
(p = 0.035). Conclusion. Out of all examined predictors, both in septic and
non-septic patients, previous kidney damage presents the greatest risk for
renal function non-recovery in critically ill patients with AKI-D.