Incidence rate of mycosis fungoides in Isfahan (Iran)

Abstract

Mycosis fungoides (MF) is an extranodal non-Hodgkin's lymphoma with primary involvement of the skin. The aim of the present study was to determine the incidence rate of MF in Isfahan (Iran) and to compare the results with other reports. We collected our data from the MF clinic of Alzahra Hospital which is the main center for treatment of MF patients in Isfahan (2007-2008). Eleven cases were reported to the MF clinic of Alzahra during the study, seven of which were diagnosed as MF. The incidence rate of MF in Isfahan in 2007-2008 was 3.91/1 million persons. The age spectrum was 28-80 years and the mean 43.14 years. The male : female ratio was 3:4. In conclusion, the incidence rate of MF in Isfahan (Iran) is similar to other areas. However, the male : female ratio is opposite to that of other studies.

Mycosis Fungoides: Epidemiology in Isfahan, Iran

“…Male to Female ratio was about 1.00 -1.4:1 in studies performed in some cities of Iran (Mashhad, Tabriz and Tehran) [21][22][23]. In present study this ratio is 1:1.57 that is similar to our previous study on incidence rate of MF in Isfahan with male: Female ratio of 3:4 (1:1.33) [24]. These ratios are completely in contrast to other studies.…”

Two distinct variants of mycosis fungoides (MF): Folliculotropic MF and erythrodermic MF

“…Mycosis fungoides (MF) and S ezary syndrome (SS) are the most common types of cutaneous T-cell lymphoma (CTCL). [1][2][3][4][5] MF has a classically prolonged clinical course and only a few cases progress over years through patch, plaque and eventually tumor stage. Many clinical and histological variants have been described.…”

Mycosis fungoides two decades after exposure to sulphur mustard: a follow‐up of 1100 victims

“…Furthermore, MF incidence rate has increased significantly since 1973. 13,14 Interestingly, we found an incidence rate of 0.799/100 000 person-years for MF among patients of the mean age 43.3 AE 9.8 (36-76 years) who had short-term exposure to SM 20 years ago. The results proposed that the age at the time of the disease diagnosis was lower in those exposed to SM in comparison to the reports from Iranian populations.…”

“…MF generally affects people in the age of 55–60 years. Furthermore, MF incidence rate has increased significantly since 1973 …”

“…The results proposed that the age at the time of the disease diagnosis was lower in those exposed to SM in comparison to the reports from Iranian populations. 13,15 The cause of MF is believed to be chronic antigenic stimulation leading to uncontrolled clonal accumulation of T cell in the skin. 16 The link of MF to some occupational factors such as ceramics industry or herbicide exposure has been studied, although their aetiology remains controversial.…”