Incidence Patterns and Survival of Gynecological Sarcoma in Germany: Analysis of Population-Based Cancer Registry Data on 1066 Women

Pietzner, Klaus; Buttmann-Schweiger, Nina; Sehouli, Jalid; Kraywinkel, Klaus

doi:10.1097/igc.0000000000001128

Cited by 20 publications

(10 citation statements)

References 12 publications

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“…A percentage range of 40-46 and 30-45% has been reported for leiomyosarcomas carcinosarcomas, respectively. In contrast to these findings, the range and percentage was estimated to 86-97% for ESSs and to 69% for adenosarcomas, respectively (20,(26)(27)(28). The rates reported in the present study were lower than those previously published.…”

Section: Uterine Sarcomas By Histological Type ----------------------contrasting

confidence: 99%

Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases

et al. 2020

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The present study aimed to assess the diagnosis, treatment and follow-up of uterine sarcoma cases. A retrospective cohort study with 122 women recruited between 2001 and 2016 was performed. The data regarding epidemiology, clinical presentation, treatment and follow-up were analyzed based on the following histological types: Carcinosarcoma, leiomyosarcoma, endometrial stromal sarcoma (ESS) and adenosarcoma. Statistical analysis included descriptive statistics, logistic regression and survival curves. The diagnosis of uterine sarcoma exhibited an increasing trend of +1.2 new cases every 2 years (P=0.044) and comprised 10% of all uterine cancer diagnoses. There were 47% carcinosarcomas, 22% leiomyosarcomas, 16% ESS and 14% adenosarcomas. The majority of the women was ≥60 years old (62%). Among the subjects, 77% were postmenopausal, 61% had a body mass index up to 29.9 kg/m 2 and 71% presented with a comorbidity. Regression analysis exhibited an association between post menopause and the histological type associated with lower overall survival (OS), namely leiomyosarcoma or carcinosarcoma (odds ratio, 5.45, P<0.001). Stage I malignancy was present in 44% and Stage IV in 22%. The treatment included primary surgery in 78% of the cases, whereas 79% received adjuvant therapy. Only 55 cases achieved disease control and 20 relapsed (36%) with a 5-year OS rate of 33%. The OS was lower for carcinosarcoma and leiomyosarcoma (20%; P=0.003). In summary, the present study indicated that the number of uterine sarcoma cases had increased between 2001 and 2016. The majority of the women were >60 years old and diagnosed in advanced stages. The postmenopausal status was associated with histological types of poor prognosis. The OS was low and worse for patients with carcinosarcoma and leiomyosarcoma.

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Section: Uterine Sarcomas By Histological Type ----------------------contrasting

confidence: 99%

Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases

et al. 2020

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“…Other studies have reported similar results, ranging from 70 to 90%. Furthermore, the most common morphological subtype among uterine sarcomas was leiomyosarcoma (37%), which was also in accordance with most of the previous studies 5–7,14–17 . However, a study reporting the results from SEER database and also a study in Japan found that carcinosarcoma was the most common type (53% and 47%) in spite of our result that was less than one‐fifth of them (9%) followed by leiomyosarcoma (24% and 36%) 18,19 .…”

Section: Discussionsupporting

confidence: 91%

“…In a population‐based study in Germany, the annual ASR of all GS cases was 6.6 in one million women (world standard population). In this study, uterine sarcomas had an incidence rate of 5.8 per million individuals 14 . Our study showed an incidence rate of 6.13 and 4.7 per million females for all sites combined and uterine sarcomas, respectively.…”

Section: Discussionsupporting

confidence: 53%

“…Furthermore, the most common morphological subtype among uterine sarcomas was leiomyosarcoma (37%), which was also in accordance with most of the previous studies. [5][6][7][14][15][16][17] However, a study reporting the results from SEER database and also a study in Japan found that carcinosarcoma was the most common type (53% and 47%) in spite of our result that was less than one-fifth of them (9%) followed by leiomyosarcoma (24% and 36%). 18,19 Uterine leiomyosarcomas were most commonly observed in the 40-64 age group, also found in a study by Ricci et al 20 Sarcomas of the vulvovaginal area accounted for 4.4% of all GS cases.…”

Section: Discussionmentioning

confidence: 66%

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Incidence patterns of gynecological sarcomas in Iran analysis of National Cancer Registry data between 2009 and 2014

Akbari

Khalili

Asef-Kabiri

et al. 2020

J of Obstet and Gynaecol

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Aim: Gynecological sarcomas (GS) are rare malignant tumors arising in the female genital organs. Due to the low incidence and diverse histology, information on the epidemiology of these tumors is sparse. We aimed to investigate the incidence rates of GS in Iran that in our knowledge is the first report from Eastern Mediterranean Region. Methods: In this retrospective study, all malignant tumors with a sarcoma morphology arising in the female genital organs diagnosed between 2009 and 2014 were extracted from the Iran National Cancer Registry dataset. All the cancer cases were categorized according to ICD-O-3 morphologic and topographic codes. Age-standardized incidence rates, age-specific incidence rates, morphologic and geographic distribution of all cases were analyzed and compared with other parts of the world. Results: A total of 1174 cases were diagnosed over the period 2009-2014. The overall age-standardized incidence rate for all sites combined was 6.13 per million females. Analysis of trends in incidence did not show a significant change over time according to annual average percent change analysis (P-value = 0.300). The most common anatomical site was the uterus, accounting for 77% of all cases. The mean (AESD) age at diagnosis, irrespective of tumor site, was 52.3 (AE15) years. In terms of morphology, leiomyosarcoma was the most frequently observed subtype, constituting 34% of all GS. Also, the highest ASIR was observed in women aged 60-64 years. Conclusion: Based on the findings, GS are relatively rare tumors that occur more in old women. The results of this study provide a comprehensive picture of GS incidence patterns in Iran for more investigation.

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“…Together with the various primary sites, they make up a large number of combinations that vary tremendously in terms of survival and clinical treatment, which means that same histological subtype in different sites may need completely different therapies 6,31 . The rarity of STSs and the even smaller number of cases in each combination further add to the difficulty faced by researchers and physicians.…”

Section: Discussionmentioning

confidence: 99%

Incidence, distribution of histological subtypes and primary sites of soft tissue sarcoma in China

et al. 2019

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Objective: Soft tissue sarcomas (STSs) are rare malignancies deriving from mesenchyme. In this study, we reported the epidemiology of STS in China using population-based cancer registry data. Methods: In 2017, qualified data from 339 cancer registries were included in the national database. All STS cases were retrieved based on the morphological and topographical codes of International Classification of Diseases for Oncology, and were categorized into different histological subtypes and primary sites accordingly. Nationwide new STS cases were estimated using incidence rate of STS and the national population, and were reported for gastrointestinal stromal tumor (GIST) and STSs other than GIST separately by sex and region. Distribution of histological subtypes and primary sites of STS were calculated, as well as primary sites of GIST. Results: Approximately 39,900 new STS cases occurred nationwide in China in 2014, accounting for 1.05% of overall cancer incidence. The crude incidence rate was 2.91/100,000 and generally increased with age. An overall female predilection was found. GIST was the most common histological subtype, followed by nerve sheath tumor and malignant peripheral nerve sheath tumor, leiomyosarcoma, liposarcoma, and fibrosarcoma. About 67.5% of GIST occurred in stomach while 1.4% were recorded outside the gastrointestinal tract. Connective, subcutaneous and other soft tissues were the most common primary site, of which extremities were the major subsite. Conclusions: The burden of STS is not serious in China relatively. However, due to their histological and topographical complexity, STSs should not be unnoticed, and more basic and clinical studies should focus on STSs.

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Incidence Patterns and Survival of Gynecological Sarcoma in Germany: Analysis of Population-Based Cancer Registry Data on 1066 Women

Abstract: Despite the rareness of GS, the size of the data set allows for a differentiation of subtypes according to morphology and site of origin. Clinically relevant differences in incidence and prognosis between subgroups were observed.

Cited by 20 publications

References 12 publications

Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases

Diagnosis, treatment and survival of uterine sarcoma: A retrospective cohort study of 122 cases

Incidence patterns of gynecological sarcomas in Iran analysis of National Cancer Registry data between 2009 and 2014

Incidence, distribution of histological subtypes and primary sites of soft tissue sarcoma in China

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