Incidence of Young Onset Dementia in Central Norway: A Population-Based Study

Kvello-Alme, Marte; Bråthen, Geir; White, Linda R.; Sando, Sigrid Botne

doi:10.3233/jad-191307

Cited by 15 publications

(30 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding subtypes, this study found that the most common subtype was AD, followed by VaD. This finding is consistent with many previous studies, 17,18,20,[26][27][28][29][30] but it is inconsistent with the previous Japanese studies, which showed that VaD was the most common, followed by AD. 19,21,25 There are several possible reasons the rankings of VaD and AD were reversed in this study.…”

Section: Discussionsupporting

confidence: 66%

Prevalence and subtype distribution of early‐onset dementia in Japan

et al. 2020

View full text Add to dashboard Cite

Aim: People living with early-onset dementia (EOD) have specific social needs. Epidemiological studies are needed to obtain current information and provide appropriate service planning. This study aimed to clarify the current prevalence and subtype distribution of EOD, as well as the services frequently used by individuals with EOD. Methods: A multisite, population-based, two-step study was conducted. Questionnaires were sent to 26 416 candidate facilities in 12 areas with a target population of 11 630 322 to inquire whether any individuals with EOD had sought services or stayed during the last 12 months (step 1). When "yes" responses were received, additional questionnaires were sent to the facilities both to complete and to distribute to the target individuals with EOD to obtain more detailed information, including the dementia subtype (step 2). Results: In step 1, valid responses were obtained from 16 848 facilities (63.8%), and 4077 cases were identified. In step 2, detailed information was obtained for 1614 cases (39.6%) from the facilities and 530 cases (13.0%) from the individuals. The national EOD prevalence rate was estimated to be 50.9/100 000 population at risk (95% confidence interval: 43.9-57.9; age range, 18-64 years). The number of individuals with EOD was estimated to be 35 700 as of 2018. Alzheimer-type dementia (52.6%) was the most frequent subtype, followed by vascular dementia (17.1%), frontotemporal dementia (9.4%), dementia due to traumatic brain injury (4.2%), dementia with Lewy bodies/Parkinson's disease dementia (4.1%), and dementia due to alcohol-related disorders (2.8%). Individuals with EOD were most frequently identified at medical centers for dementia. Conclusion: The prevalence rate estimated in this study was comparable to those in previous studies in Japan. However, the subtype distribution differed, with Alzheimer-type dementia being the most prominent. Based on the case identification frequencies, medical centers for dementia are expected to continue to function as the primary special health service by providing quality diagnosis and post-diagnostic support for individuals with EOD.

show abstract

Section: Discussionsupporting

confidence: 66%

Prevalence and subtype distribution of early‐onset dementia in Japan

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Our results are also in line with 2 studies: one performed in the province of Modena in Italy (2006 to 2019, PR = 119.9/100,000) [ 41 ] and the other in 4 catchment areas of eastern Sydney, Australia (2007 to 2008, PR = 133/100,000 between 45 and 64 years; the PR for this age group in our study was 127/100,000) [ 11 ]. Regarding incidence, 2 recent field studies provided IR that were consistent with our findings; in the Italian study mentioned above, the IR was 22.8/100,000, and it was 25.0/100,000 between 45 and 64 years in a population-based study in Norway (2015 to 2017) [ 11 , 17 ].…”

Section: Discussionsupporting

confidence: 90%

“…In the context of population aging, data on YOD are of major importance to anticipate needs for planning and allocation of health and social resources [ 8 ]. Some field and register studies provided heterogeneous estimates of YOD prevalence, ranging from 38 to 420/100,000 between 30 and 64 years [ 9 – 17 ]. Fewer studies are available regarding YOD incidence, and methodological differences likely explain inconsistent results between them [ 9 – 11 , 16 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and incidence of young onset dementia and associations with comorbidities: A study of data from the French national health data system

et al. 2021

View full text Add to dashboard Cite

Background Dementia onset in those aged <65 years (young onset dementia, YOD) has dramatic individual and societal consequences. In the context of population aging, data on YOD are of major importance to anticipate needs for planning and allocation of health and social resources. Few studies have provided precise frequency estimates of YOD. The aim of this study is to provide YOD prevalence and incidence estimates in France and to study the contribution of comorbidities to YOD incidence. Methods and findings Using data from the French national health data system (Système National des Données de Santé, SNDS) for 76% of the French population aged 40 to 64 years in 2016 (n = 16,665,795), we identified all persons with dementia based on at least 1 of 3 criteria: anti-Alzheimer drugs claims, hospitalization with the International Classification of Diseases-10th Revision (ICD-10) dementia code (F00 to F03, G30, G31.0, G31.1, or F05.1), or registration for free healthcare for dementia. We estimated prevalence rate (PR) and incidence rate (IR) and estimated the association of comorbidities with incident YOD. Sex differences were investigated. We identified 18,466 (PRstandardized = 109.7/100,000) and 4,074 incident (IRstandardized = 24.4/100,000 person-years) persons with prevalent and incident YOD, respectively. PR and IR sharply increased with age. Age-adjusted PR and IR were 33% (95% confidence interval (CI) = 29 to 37) and 39% (95% CI = 31 to 48) higher in men than women (p < 0.001 both for PR and IR). Cardio- and cerebrovascular, neurological, psychiatric diseases, and traumatic brain injury prevalence were associated with incident YOD (age- and sex-adjusted p-values <0.001 for all comorbidities examined, except p = 0.109 for antihypertensive drug therapy). Adjustment for all comorbidities explained more than 55% of the sex difference in YOD incidence. The lack of information regarding dementia subtypes is the main limitation of this study. Conclusions We estimated that there were approximately 24,000 and approximately 5,300 persons with prevalent and incident YOD, respectively, in France in 2016. The higher YOD frequency in men may be partly explained by higher prevalence of cardiovascular and neurovascular diseases, substance abuse disorders, and traumatic brain injury and warrants further investigation.

show abstract

“…reported 5.8/100 000 person‐years in the population aged 21–64 years in Argentina 13 ; and Kvello‐Alme et al . reported 14.8/100 000 person‐years in the population aged 30–64 years in Norway. 14 …”

Section: Discussionmentioning

confidence: 99%

Incidence and distribution of subtypes of early‐onset dementia in Japan: A nationwide analysis based on annual performance reports of the Medical Centers for Dementia

Edahiro

Miyamae

Taga

et al. 2020

Geriatrics Gerontology Int

View full text Add to dashboard Cite

Investigating the incidence rate of early-onset dementia is challenging. We explored the incidence rate of early-onset dementia in Japan using annual performance reports from the Medical Centers for Dementia. Methods: Medical Centers for Dementia are specialized health services for dementia established as part of Japan's national health program. There are 440 such centers nationwide as of 2018. Using the annual performance reports of these centers, we calculated the number of newly diagnosed cases of early-onset dementia or late-onset dementia from April 1, 2018 to March 31, 2019, and the composition ratio by diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The annual incidence rate of early-onset dementia was estimated using the number of cases as the numerator and the national population aged 18-64 years as the denominator. Results: In total, 1733 of cases were diagnosed with early-onset dementia, of which 52.1% were diagnosed as major neurocognitive disorder due to Alzheimer's disease, 8.9% major frontotemporal neurocognitive disorder, 8.8% major vascular neurocognitive disorder, 7.1% substance/medication-induced major neurocognitive disorder, 6.5% major neurocognitive disorder with Lewy bodies and 3.9% major neurocognitive disorder due to another medical condition. The annual incidence rate of early-onset dementia was estimated to be 2.47/100 000 person-years. Conclusions: This study provides the first nationwide estimate of the incidence rate of early-onset dementia in Japan and suggests that Medical Centers for Dementia are important resources for the epidemiological monitoring of early-onset dementia nationwide.

show abstract

Incidence of Young Onset Dementia in Central Norway: A Population-Based Study

Cited by 15 publications

References 46 publications

Prevalence and subtype distribution of early‐onset dementia in Japan

Prevalence and subtype distribution of early‐onset dementia in Japan

Prevalence and incidence of young onset dementia and associations with comorbidities: A study of data from the French national health data system

Incidence and distribution of subtypes of early‐onset dementia in Japan: A nationwide analysis based on annual performance reports of the Medical Centers for Dementia

Contact Info

Product

Resources

About