Incidence of Venous Thromboembolism in the Year Before the Diagnosis of Cancer in 528 693 Adults

White, Richard; Chew, Helen K.; Zhou, Hong; Parikh‐Patel, Arti; Harris, David; Harvey, Danielle; Wun, Theodore

doi:10.1001/archinte.165.15.1782

Cited by 217 publications

(142 citation statements)

References 24 publications

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“…The risk of thrombosis in patients with cancer also increases with the use of chemotherapy, hormonal therapy, and indwelling central venous catheters and may increase by 4-to 6-folds [17]. In addition, the occurrence of VTE in asymptomatic patients may antedate the clinical diagnosis of cancer [18]. Therefore, patients with apparent idiopathic VTE could have a risk of occult malignancy and need to be screened for cancer [19,20].…”

Section: Discussionmentioning

confidence: 99%

Deep vein thrombosis in patients with advanced liver cirrhosis: a rare condition?

Lesmana

Inggriani²,

Cahyadinata³

et al. 2010

Hepatol Int

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Purpose Patients with liver cirrhosis are generally considered to be ''auto-anticoagulated'' because of coagulopathy and thrombocytopenia. However, deep vein thrombosis (DVT) has been reported in patients with liver cirrhosis. The objectives of this study were to know the prevalence of DVT among cirrhotic patients and to compare clinical pictures between cirrhotic patients with and without DVT. Methods A case-control study was performed on the basis of medical record data of patients with liver cirrhosis admitted between August 2004 and July 2007 in Medistra hospital in Jakarta. Diagnosis of DVT was established by duplex Doppler ultrasonography of the lower extremities. Patients with splanchnic thrombosis were excluded from this study. Diagnosis of liver cirrhosis was based on history and clinical manifestation, consistent with liver cirrhosis and confirmed by ultrasonography or computed tomography. Results A total of 256 patients with liver cirrhosis were included in this study; 164 (64.1%) among them were men. Patients' mean age was 60.5 ± 12.5 years, ranging from 16 to 88 years. Viral hepatitis accounted for 74.6% of patients with liver cirrhosis. DVT was found in 12 (4.7%)patients. There was no significant laboratory difference between cirrhotic patients with and without DVT (serum albumin, platelet count, aminotransferases, c-glutamyl transpeptidase, alkaline phosphatase, total bilirubin levels, and prothrombin time). Diabetes mellitus was significantly higher in the DVT group than that in the control group (66.6 vs. 34.0%, P = 0.025). Multivariate analysis confirmed diabetes mellitus as an independent risk factor for the occurrence of DVT (odds ratio = 4.26; 95% confidence interval = 1.206-15.034; P = 0.024). Conclusions The prevalence of DVT in patients with liver cirrhosis was 4.7%, and Deep vein thrombosis is not a rare condition in cirrhotic patients with coagulopathy and warrants further studies on the mechanisms and prevention.

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Section: Discussionmentioning

confidence: 99%

Deep vein thrombosis in patients with advanced liver cirrhosis: a rare condition?

Lesmana

Inggriani²,

Cahyadinata³

et al. 2010

Hepatol Int

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“…The occurrence of thromboembolism can precede the diagnosis of malignant disease by months or years [1][2][3] or can occur subsequent to cancer diagnosis [4,5]. Patients with cancer have an inherently increased risk of developing VTE [6 -9] because of the presence of major risk factors, including cancer-associated hypercoagulable state, vessel wall damage and vessel stasis from direct compression, advanced age, surgical procedures, prolonged immobilization, frequent hospitalization, use of erythropoietic stimulating agents, and the frequent use of indwelling vascular catheters and chemotherapeutic regimens.…”

Section: Introductionmentioning

confidence: 99%

“…VTE incidence varies across cancer stages; the incidence of VTE in colorectal cancer is largely confined to patients with advanced disease [2,4,12,14]. A high predisposition for the development of VTE exists for patients with colon cancer with the following principal risk factors: hospitalization, regional stage or metastatic disease, number of chronic comorbid conditions, systemic chemotherapy, prior VTE, African American race, and advanced age [2,4,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Impact of Venous Thromboembolism on Mortality of Elderly Medicare Patients with Stage III Colon Cancer

et al. 2012

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After completing this course, the reader will be able to:1. Identify the prevalence of adjuvant chemotherapy utilization in elderly patients with stage III colon cancer.2. Discuss the prevalence and impact of venous thromboembolism in elderly patients with stage III colon cancer.3. Identify potential for development of a clinical trial to study the clinical benefit and impact on cancer-specific and all-cause mortality of thromboprophylaxis during adjuvant chemotherapy in elderly patients with stage III colon cancer.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTBackground. The improvement in survival rates for patients with colon cancer has shifted the focus from examining cancer-specific mortality to exploring all-cause mortality. Adverse events such as venous thromboembolism (VTE) affect overall survival times and the net clinical benefit of cancer management strategies.Methods. This retrospective study used Surveillance, Epidemiology and End Results (SEER) Medicare data to examine VTE incidence and mortality rates for elderly

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“…Data on patients with acute leukaemia have been scarce until very recently. However, an increased standardised incidence ratio of preceding VTE has been noticed in AML among other malignancies (White et al, 2005).…”

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confidence: 99%

Increased risk of venous thromboembolism in patients with acute leukaemia

et al. 2006

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Incidence of Venous Thromboembolism in the Year Before the Diagnosis of Cancer in 528 693 Adults

Cited by 217 publications

References 24 publications

Deep vein thrombosis in patients with advanced liver cirrhosis: a rare condition?

Deep vein thrombosis in patients with advanced liver cirrhosis: a rare condition?

Impact of Venous Thromboembolism on Mortality of Elderly Medicare Patients with Stage III Colon Cancer

Increased risk of venous thromboembolism in patients with acute leukaemia

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