Incidence of uveitis and macular edema among patients taking fingolimod 0.5 mg for multiple sclerosis

Abstract

Background Patients with multiple sclerosis (MS) have a higher incidence of uveitis compared with the general population. Fingolimod, a first line disease modifying drug used in multiple sclerosis, may cause macular edema and thus requires ophthalmic examination. However, murine models and anecdotal reports suggest fingolimod may reduce the incidence of uveitis. Purpose To report the incidence of uveitis and macular edema among those on fingolimod 0.5 mg (Gilenya®) therapy for multiple sclerosis (MS). Methods Retrospective review of patients on fingolimod who developed uveitis and/or macular edema. Results No patients had an occurrence or history of uveitis. Four of the 188 (2.13%) patients developed macular edema without ocular inflammation. One of the 188 (0.53%) patients developed Acute Macular Neuroretinopathy. Conclusion Patients taking fingolimod have a lower incidence of uveitis than expected in a population of MS patients.

The Effect of Fingolimod (FTY720) Treatment on Liver Enzyme Levels in Relapsing-Remitting Multiple Sclerosis Patients

“…FT, despite well-tolerated in MS patients, has several side effects including macular edema, lymphopenia, hypertension and more commonly increased liver enzymes (6,18,19). In the present study, we retrospectively evaluated the effect of FT on liver enzyme levels (ALT and GGT) in RRMS patients and observed that both ALT and GGT were increased in the patients.…”

Drugs Causing Cystoid Macular Edema: Pathogenesis, Diagnosis, and Treatment

“…[64] Ayrıca, topikal kortikosteroidler ve NSAİİ'ler, intravitreal triamsinolon, oral karbonik anhidraz inhibitörlerinin etkili olduğunu bildiren ayrı ayrı çalışmalar vardır. [70,71] Fingolimod kullanan MS hastalarında gelişen makuler ödemin ilaç kullanımına bağlı olarak mı yoksa MS ile ilişkili üveite sekonder mi geliştiği iyi ayırt edilerek tedavi buna göre düzenlenmelidir. [63,64] Sonuç Kistoid makuler ödem, ağrısız görme kaybının önemli bir sebebidir.…”