Incidence of Use of Acid Suppression Medications in Infants with Oral Clefting

Koltz, Peter F.; Albino, Frank P.; Hyatt, Brad T.; Fargione, Robert A.; Katzel, Evan B.; Girotto, John A.

doi:10.1597/09-165

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…A causative factor of feeding dysfunction and poor infant growth in these infants includes GERD. Prior literature suggests that infants with CL/P have increased rates of GERD compared to the general pediatric population, perhaps because of anatomic variation but also perhaps due to a pathophysiological connection between clefting and GERD (Koltz et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Feeding dysfunction can lead to feeding aversion or refusal in neonates (Prasse and Kikano, 2009). Furthermore, it appears gastroesophageal reflux (GERD) occurs more commonly with cleft deformities (9%) than in the general pediatric population (<1%) (Koltz et al, 2010). A total of 33% of infants with CL/P have documented signs and symptoms of GERD (Koltz et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Ultrasound Measurement of Fetal Stomach Size Is Predictive of Postnatal Development of GERD in Isolated Cleft Lip and/or Palate

Toscano

Burhans

Mack

et al. 2020

The Cleft Palate-Craniofacial Journal

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Objective: To determine whether prenatal ultrasound measurement of fetal stomach size, as a surrogate marker of fetal swallowing, is predictive of postnatal development of gastroesophageal reflux disease (GERD) in cases of isolated cleft lip and/or palate (CL/P). Design: This is a retrospective case–control study. The outcome of interest is postnatal diagnosis of GERD in isolated CL/P. The exposure of interest is prenatal stomach size measurement by ultrasound. Setting: The study population was selected from an academic, tertiary care center between 2003 and 2011. Patients/Participants: Cases were neonates undergoing CL/P repair during the study period. Cases with other known structural or chromosomal abnormalities were excluded. Controls were contemporary, nondiabetic neonates that matched gestational age (within one week) to cases. Each case measurement was matched ∼1:2 with control measurement. Interventions: None. Main Outcome Measure: The primary outcome was difference in mean prenatal ultrasound measurement of fetal stomach size between cases and controls. We hypothesized that patients with postnatal development of GERD would have smaller mean fetal stomach size. Results: There were 32 cases including 19 patients with unilateral cleft lip and palate, 8 with unilateral cleft lip, and 4 with bilateral cleft lip and palate. Cases were noted to have smaller mean anterior–posterior and transverse fetal stomach measurements as compared to controls. This was statistically significant from 16 to 21 weeks, 25 to 27 weeks, and 28 to 36 weeks ( P < .01 for all). Conclusions: Prenatal ultrasound measurement of fetal stomach size as a surrogate marker of fetal swallowing is predictive of postnatal development of GERD in isolated CL/P.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal Ultrasound Measurement of Fetal Stomach Size Is Predictive of Postnatal Development of GERD in Isolated Cleft Lip and/or Palate

Toscano

Burhans

Mack

et al. 2020

The Cleft Palate-Craniofacial Journal

Self Cite

View full text Add to dashboard Cite

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Incidence of Gastroesophageal Reflux Disease in Children With Cleft Lip and Palate and an Evaluation of Its Impact on Weight Gain

et al. 2020

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Patients with cleft lip and/or palate have higher rates of failure to thrive (FTT), decreased growth, and more often experience feeding difficulties as compared with the general pediatric population (J Child Health Care. 2014;18:72–83). Although insufficient nursing, excessive air intake, and incorrect feeding methods have been established in the literature, the role of gastroesophageal reflux disease (GERD) as a contributing factor in cleft patients has not been thoroughly examined. Presently, there is a paucity of literature analyzing the incidence and effect of GERD on this unique population. Furthermore, no studies have evaluated the effect of GERD therapy on improvement of weight gain and FTT in cleft patients. The purpose of this retrospective review was to identify the incidence of GERD in the orofacial cleft population and to see if appropriate treatment was effective in improving weight gain. Fifty patients with cleft lip, cleft lip and palate, and isolated cleft palate were identified from a single surgeon's experience at a large academic medical center from 2015 to 2019. The data show that a significantly higher percentage of patients with cleft lip/and or palate have clinical evidence of GERD, which required treatment as compared with published reports of less than 1% in the noncleft population. The data also suggest that the patients diagnosed with GERD who received pharmacologic treatment showed improved weight gain as compared with those who did not. Given our findings, the diagnosis of GERD should be considered in orofacial cleft patients exhibiting signs of feeding difficulty or those with FTT. The early diagnosis and treatment of GERD in patients with orofacial clefts may improve weight gain.

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Incidence of Use of Acid Suppression Medications in Infants with Oral Clefting

Cited by 2 publications

References 24 publications

Prenatal Ultrasound Measurement of Fetal Stomach Size Is Predictive of Postnatal Development of GERD in Isolated Cleft Lip and/or Palate

Prenatal Ultrasound Measurement of Fetal Stomach Size Is Predictive of Postnatal Development of GERD in Isolated Cleft Lip and/or Palate

Incidence of Gastroesophageal Reflux Disease in Children With Cleft Lip and Palate and an Evaluation of Its Impact on Weight Gain

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