Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study

Ólafsson, Elías; Lúðvígsson, Pétur; Hesdorffer, Dale C.; Kjartansson, Ólafur; Hauser, W. Allen; Guðmundsson, Gunnar

doi:10.1016/s1474-4422(05)70172-1

Cited by 308 publications

(218 citation statements)

References 24 publications

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“…This finding is also not inconsistent with other studies, where provided, age-specific incidence is consistently high in the youngest age groups, with highest incidence occurring during the first few months of life. Incidence falls dramatically after the first year of life, seems relatively stable through the first decade of life, and falls again during adolescence [44][45][46] . Seizure was also more frequent in male.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and Specificity of Electroencephalography (EEG) Among Patients Referred to an Electrophysiology Lab in Bangladesh

Chowdhury¹,

Chowdhury²,

Khan³

et al. 2015

J Dhaka Med Coll

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Section: Discussionmentioning

confidence: 99%

Sensitivity and Specificity of Electroencephalography (EEG) Among Patients Referred to an Electrophysiology Lab in Bangladesh

Chowdhury¹,

Chowdhury²,

Khan³

et al. 2015

J Dhaka Med Coll

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“…The risk of epileptic seizures is particularly high in AD patients with earlyonset dementia and during early stages of the disease, reaching an 87-fold increase in seizure incidence compared with an agematched reference population (Amatniek et al, 2006). Whether this comorbidity is just a coincidence because of high prevalence of both AD and epilepsy in the elderly over 65 years of age (Breteler et al, 1992;Olafsson et al, 2005) or whether AD pathology makes the brain particularly susceptible to seizure generation remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

Minkeviciene¹,

Rheims²,

Dobszay³

et al. 2009

J. Neurosci.

573

544

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Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here, we performed video-EEG recordings in mice carrying mutant human APPswe and PS1dE9 genes (APdE9 mice) and their wild-type littermates to determine the prevalence of unprovoked seizures. In two recording episodes at the onset of amyloid ␤ (A␤) pathogenesis (3 and 4.5 months of age), at least one unprovoked seizure was detected in 65% of APdE9 mice, of which 46% had multiple seizures and 38% had a generalized seizure. None of the wild-type mice had seizures. In a subset of APdE9 mice, seizure phenotype was associated with a loss of calbindin-D28k immunoreactivity in dentate granular cells and ectopic expression of neuropeptide Y in mossy fibers. In APdE9 mice, persistently decreased resting membrane potential in neocortical layer 2/3 pyramidal cells and dentate granule cells underpinned increased network excitability as identified by patch-clamp electrophysiology. At stimulus strengths evoking single-component EPSPs in wild-type littermates, APdE9 mice exhibited decreased action potential threshold and burst firing of pyramidal cells. Bath application (1 h) of A␤1-42 or A␤25-35 (proto-)fibrils but not oligomers induced significant membrane depolarization of pyramidal cells and increased the activity of excitatory cell populations as measured by extracellular field recordings in the juvenile rodent brain, confirming the pathogenic significance of bath-applied A␤ (proto-)fibrils. Overall, these data identify fibrillar A␤ as a pathogenic entity powerfully altering neuronal membrane properties such that hyperexcitability of pyramidal cells culminates in epileptiform activity.

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“…The description of the spell was consistent with seizure in 90.7% (48), syncope in 3.9% (2), and migraine variant in 1.9% (1) of cases. The three seizure types described were generalized tonic-clonic seizures (grand mal) in 93.8% (45), complex partial seizures in 4.2% (2), and tonic seizures in 2.1% (1) of presumed seizures.…”

Section: Resultsmentioning

confidence: 59%

“…The three seizure types described were generalized tonic-clonic seizures (grand mal) in 93.8% (45), complex partial seizures in 4.2% (2), and tonic seizures in 2.1% (1) of presumed seizures.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 23.5 per 100,000 person-years had a single unprovoked seizure compared with 33.3 per 100,000 person-years who later developed epilepsy. 2 The numbers are considered representative for most developed countries. In another study, 3 the overall incidence of unprovoked seizures in both children and adults in Sweden was 60 per 100,000.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single Unprovoked Seizure: Wait Time to Full Medical Assessment, Does It Matter?

Anang¹,

Téllez‐Zenteno²

2012

Neurol. Bull.

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IntroductionSingle unprovoked seizures occur in about 4% of the population and they have significant psychosocial consequences for the patients and their families. Little information is available on the timeliness and safety of assessment of first unprovoked seizures. In this study, we review the timeliness of the referral and evaluation of patients with first unprovoked seizure in a Canadian neurological provincial referral center. MethodRetrospective analysis of 51 patients over a 3.5 year period was performed and data were collected on patient demographics, date of event and time to evaluation by the epileptologist, evaluations completed, treatments initiated, and patient outcomes. ResultsWe found that most patients were seen by the epileptologist within 6 months, there was only a 9% discrepancy in final diagnoses between the epileptologist and the referring physician, and there were no fatalities or serious complications in the patients we studied. However, a few patients waited very long periods before imaging and evaluation by the epileptologist, and restrictions on driving privileges were recommended in only 3% of the patients. ConclusionsWe conclude that the referral process for a first unprovoked seizure is timely. Primary care providers need further education with regards to the consequences of seizures and some areas of the referral region need better access to imaging and epileptologists.

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Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study

Cited by 308 publications

References 24 publications

Sensitivity and Specificity of Electroencephalography (EEG) Among Patients Referred to an Electrophysiology Lab in Bangladesh

Sensitivity and Specificity of Electroencephalography (EEG) Among Patients Referred to an Electrophysiology Lab in Bangladesh

Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

Single Unprovoked Seizure: Wait Time to Full Medical Assessment, Does It Matter?

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