Incidence of Tuberculosis and Amyloidosis among Sudanese Patients Presented with Enlarged Nodes

Eldour, Ahmed Abdalla Agab; Salih, Entisar Najeeb Mohmed; Ahmed, Hussain Gadelkarim

doi:10.1155/2014/832029

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…У больных с пневмонией или муковисцидозом в легочной мокроте был локализован ряд штаммов бак- [26]. Несмотря на то, что прямых доказательств продукции амилоида микобактериями туберкулеза и лейшманиями нет, штаммы микобактерий туберкулеза и культуры лейшманий используются для моделирования системного амилоидоза в эксперименте [27].…”

Section: обзорunclassified

Epidemiology of amyloidosis (prevalence of etiological thinking)

Kozlov¹,

Сапожников²,

Голенков³

2021

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Амилоидоз - патологический процесс, вызванный различными средовыми и наследственными этиологическими факторами, развивающийся по собственным законам вне зависимости от первичных причин, его вызвавших. По этой причине систематизация сведений об эпидемиологии амилоидной болезни является трудной задачей по причине различий используемых методик статистического анализа, отсутствия единой, принятой во всем мире классификации этой патологии, различий учета этой патологии клиницистами и патологоанатомической службой. Неcмотря на наличие классификации амилоидозов ВОЗ, основанной на патогенетическом принципе, статистический учет случаев амилоидоза проводится по отдельным нозологическим формам. Поэтому часть случаев амилоидоза проходит мимо статистического учета. В целом это создает неправильное впечатление, что амилоидоз встречается значительно реже, чем это есть на самом деле. Цель исследования - анализ доступных данных литературы по эпидемиологии амилоидоза для приблизительной оценки реальной картины распространенности этого вида патологии. Результаты. Проведен анализ данных литературы по эпидемиологии амилоидоза, болезни Альцгеймера, АL- и AA-амилоидозов, LECT2 амилоидоза, наследственных амилоидозов, фармакологического амилоидоза и амилоидоза, вызванного приемом наркотических средств. Проанализированы связи распространённости амилоидоза с возрастом и полом. Выявлены различия методов исследования эпидемиологии амилоидоза, приводящие к получению несопоставимых данных. Поскольку разные авторы не использовали единые методики оценки эпидемиологии амилоидоза, данные, полученные в одном и том же географическом районе, различаются иногда на порядок. Предложена к обсуждению собственная классификация амилоида по происхождению. Поскольку амилоидоз является не диагнозом, а патологическим процессом, предлагается отказаться от нозологического принципа статистического учета случаев амилоидоза в пользу патогенетической классификации ВОЗ. Заключение. Единых сопоставимых сведений о распространенности и заболеваемости амилоидозом нет, по этой причине необходимо введение обязательного исследования материала биопсий и аутопсий на наличие амилоида с помощью окрашивания конго красным. Также необходимо создание цифрового национального реестра больных амилоидозом и разработка методов ранней прижизненной диагностики амилоидоза, возможно, на основе протеомного анализа плазмы крови. Amyloidosis is a pathological process caused by various environmental and hereditary etiological factors. It develops according to its own rules, regardless of the primary events that caused it. Systematization of information about amyloid disease epidemiology is a challenging task due to differences in the methods used for statistical analysis, the lack of a unified worldwide classification of this pathology, and differences in the description of this pathology by clinicians and pathologists. Despite a WHO classification of amyloidosis based on a pathogenetic principle, statistics on some amyloidosis cases are performed by individual nosological forms. Therefore, some amyloidosis cases are not included in statistical analyses. In general, this creates an incorrect impression that amyloidosis is much less common than it actually is. The aim of this study is to analyze the available literature data on the epidemiology of amyloidosis in order to approximate the correct prevalence of this pathology. Results. The published data on the epidemiology of amyloidosis, Alzheimer’s disease, AL- and AA-amyloidoses, LECT2 amyloidosis, hereditary amyloidoses, pharmacological amyloidosis, and narcotic drug induced amyloidosis were analyzed. Also the relationship of amyloidosis with age and sex was taken into account. Differences were identified in research methods for the epidemiology of amyloidosis that led to incompatible data. Since different authors use different methods for assessing the epidemiology of amyloidosis, data obtained in the same geographical area sometimes differed by an order of magnitude. Own classification of amyloidosis by origin is proposed for discussion. Since amyloidosis is not a diagnosis, but a pathological process, it is proposed to abandon the nosological principle of statistical accounting of amyloidosis cases in favor of the WHO pathogenetic classification. Conclusion. There are no uniformly comparable data on the prevalence and incidence of amyloidosis. For this reason, mandatory staining with Congo red of biopsy and autopsy material for the presence of amyloid is required. It is also necessary to create a digital national registry of patients with amyloidosis and to develop methods for early lifetime diagnosis of amyloidosis, possibly based on proteomic analysis of blood plasma.

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Section: обзорunclassified

Epidemiology of amyloidosis (prevalence of etiological thinking)

Kozlov¹,

Сапожников²,

Голенков³

2021

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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“…Autoinflammatory diseases (AIDs) are currently regarded as the most prevalent cause of secondary AA amyloidosis in children, due to the accumulation and deposition of SAA 5 . Differently, chronic infections like tuberculosis still represent an important cause of reactive amyloidosis in low‐income countries 6 . AIDs are a large group of rare inherited diseases that are characterized by hyperactivation of the innate immunity, often impacting renal health due to the development of sterile inflammation and glomerular deposition of amyloid fibrils 5,7 .…”

Section: Introductionmentioning

confidence: 99%

“…5 Differently, chronic infections like tuberculosis still represent an important cause of reactive amyloidosis in low-income countries. 6 AIDs are a large group of rare inherited diseases that are characterized by hyperactivation of the innate immunity, often impacting renal health due to the development of sterile inflammation and glomerular deposition of amyloid fibrils. 5,7 Although AIDs may be polygenic with epigenetic variables impacting their phenotype, the majority of them is caused by mutations in single genes, being referred to as "monogenic AIDs".…”

mentioning

confidence: 99%

Renal involvement in monogenic autoinflammatory diseases: A narrative review

et al. 2023

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Autoinflammatory diseases (AIDs) are mostly caused by dysfunctions in single genes encoding for proteins with a prominent role in the regulation of innate immunity, such as complement factors, inflammasome components, tumour necrosis factor (TNF)-α, and proteins belonging to type I-interferon (IFN) signalling pathways. Due to the deposition of amyloid A (AA) fibrils in the glomeruli, unprovoked inflammation in AIDs frequently affects renal health. In fact, secondary AA amyloidosis is the most common form of amyloidosis in children. It is caused by the extracellular deposition of fibrillar low-molecular weight protein subunits resulting from the degradation and accumulation of serum amyloid A (SAA) in numerous tissues and organs, primarily the kidneys. The molecular mechanisms underlying AA amyloidosis in AIDs are the elevated levels of SAA, produced by the liver in response to pro-inflammatory cytokines, and a genetic predisposition due to specific SAA isoforms. Despite the prevalence of amyloid kidney disease, non-amyloid kidney diseases may also be responsible for chronic renal damage in children with AIDs, albeit with distinct characteristics. Glomerular damage can result in various forms of glomerulonephritis with distinct histologic characteristics and a different underlying pathophysiology. This review aims to describe the potential renal implications in patients with inflammasomopathies, type-I interferonopathies, and other rare AIDs in an effort to improve the clinical course and quality of life in paediatric patients with renal involvement.

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“…form of extra-pulmonary tuberculosis reported worldwide [1][2][3][4]. It is the same in Sri Lanka as well culture or polymerase chain reaction (PCR) of M. tuberculosis in affected nodes.…”

Section: Introductionmentioning

confidence: 99%

Clinico-demographic profile of patients treated for Tuberculous Lymphadenitis at the Central Chest Clinic, Colombo, Sri Lanka

Amarasinghe¹,

Fernando²,

Sadikeen³

et al. 2018

Cey. J. Med. Sci.

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Background: treatment. Objective: with clinical presentation, diagnostic modalities and treatment outcome Method: An audit was carried out revising clinical records of patients treated for peripheral lymph node enlargement due to tuberculosis at the Central Chest Clinic, Colombo. Results: were the cervical lymph nodes (94%). Mantoux test positivity (>10mm) primary investigations was seen in 122 (97%) of patients. Out of all supportive primary and ancillary diagnostic tests. Paradoxical reactions reactions and drug induced hepatitis were noted in 17%. Eighty-two patients achieved complete clinical resolution at the end of 6 months while others were found to have residual lymph nodes necessitating further evaluation. Conclusions: treated based on primary and ancillary diagnostic test results. Prospective studies are recommended for more descriptive assessment. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

show abstract

Incidence of Tuberculosis and Amyloidosis among Sudanese Patients Presented with Enlarged Nodes

Cited by 5 publications

References 28 publications

Epidemiology of amyloidosis (prevalence of etiological thinking)

Epidemiology of amyloidosis (prevalence of etiological thinking)

Renal involvement in monogenic autoinflammatory diseases: A narrative review

Clinico-demographic profile of patients treated for Tuberculous Lymphadenitis at the Central Chest Clinic, Colombo, Sri Lanka

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