Incidence of transient global amnesia in the Belluno province, Italy: 1985 through 1995

Lauria, Giuseppe; Gentile, M.; Fassetta, G; Casetta, Ilaria; Caneve, Giorgio

doi:10.1111/j.1600-0404.1997.tb00215.x

Cited by 35 publications

(22 citation statements)

References 53 publications

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“…In the present study, patient age, gender distribution, provoking factors, and accompanying symptoms were similar to those of previous reports on TGA patients [7,14,15]. However, DWI alterations in the hippocampal region were present in only 7.9% of our TGA patients, a much lower proportion than noted in several previous studies of TGA [6,11,16,17].…”

Section: Discussioncontrasting

confidence: 29%

Transient Global Amnesia: Seven Years of Experience with Diffusion-Weighted Imaging in an Emergency Department

Ahn¹,

Kim²,

Lee³

et al. 2011

Eur Neurol

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Background/Aims: Hippocampal lesions on diffusion-weighted imaging (DWI) are commonly described in transient global amnesia (TGA). We evaluated the utility of DWI and the presence of hippocampal lesions in the diagnosis of TGA. Methods: A total of 203 TGA episodes were diagnosed at our emergency department from January 2003 to May 2010. DWI (5-mm slice thickness) was performed using a 1.5 T scanner. Patients were divided into 2 groups based on the presence of hippocampal lesions on DWI: DWI– and DWI+. The clinical characteristics and the time interval from development of amnesia to magnetic resonance imaging (MRI) were compared. Results: 16 patients had hippocampal lesions on DWI. The DWI– and DWI+ groups had similar clinical characteristics. The overall median time interval from amnesia to MRI was 6 h, and this interval was significantly longer for the DWI+ group than the DWI– group [9 h (IQR 6.5–25) vs. 5 h (IQR 4–9), p = 0.002]. Conclusion: DWI has a low diagnostic yield when performed early in the course of TGA. Positive findings can confirm the diagnosis, but in negative results, careful interpretation is required, including the time interval from amnesia to MRI.

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Section: Discussioncontrasting

confidence: 29%

Transient Global Amnesia: Seven Years of Experience with Diffusion-Weighted Imaging in an Emergency Department

Ahn¹,

Kim²,

Lee³

et al. 2011

Eur Neurol

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“…Its annual incidence has been reported to be 3.4 to 10.4 per 100,000 people. 6,[14][15][16] If we narrow it to the population older than 50 years, the incidence increases to 23.5 per 100,000 per year. 17 It is more common in individuals with migraine.…”

Section: Epidemiologic Profilementioning

confidence: 96%

Transient Global Amnesia

Arena

Rabinstein

2015

Mayo Clinic Proceedings

108

183

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“…TGA is, in general, a rare condition with an estimated incidence of 5-9/100 000 per year. 9 However, there have been 35 reports of amnesia as a symptom among 274 adverse event reports between January 1998 and February 2001, which designated sildenafil as the primary suspect of various neurological disturbances. 10 PDE-5 inhibitors interact pharmacologically with nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) signalling pathways.…”

Section: Discussionmentioning

confidence: 99%

Transient global amnesia after intake of tadalafil, a PDE-5 inhibitor: a possible association?

Schiefer¹,

Sparing²

2005

Int J Impot Res

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Inhibitors of phosphodiesterase type 5 (PDE-5) are well established as an oral treatment for the majority of patients with erectile dysfunction (ED). PDE-5 is found in high concentration in smooth muscle cells of the corpora cavernosa. However, enzymes of the PDE family are also expressed in various other tissues, including the brain. Little is known about its effects on the central nervous system (CNS), although it has been suggested that PDE-5 inhibitors might cross the blood-brain barrier. Side effects, such as headache, nasal congestion, flushing, nausea, are much more common. We describe a patient who had a transient global amnesia (TGA) after his first-ever use of tadalafil, a potent PDE-5 inhibitor. Despite the fact that the aetiology of TGA has not entirely been clarified at present, we consider the hypothesis of a causal relationship as tempting with respect to the current hypotheses of TGA pathophysiology. This case, together with others, suggests that PDE-5 inhibitors might be capable of exerting adverse effects in the CNS. Physicians should be aware of the possibility of neurological disturbances when prescribing PDE-5 inhibitors for ED.

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Incidence of transient global amnesia in the Belluno province, Italy: 1985 through 1995

Cited by 35 publications

References 53 publications

Transient Global Amnesia: Seven Years of Experience with Diffusion-Weighted Imaging in an Emergency Department

Transient Global Amnesia: Seven Years of Experience with Diffusion-Weighted Imaging in an Emergency Department

Transient Global Amnesia

Transient global amnesia after intake of tadalafil, a PDE-5 inhibitor: a possible association?

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