Incidence of total knee and hip replacement due to osteoarthritis in relation to circulating sex steroid hormone concentrations in women

Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men

“…Participants were censored at the date of first arthroplasty performed for indications other than OA, the date of death, the date left Australia, or end of follow-up (31 December 2013), whichever came first. Each analysis was adjusted for age, BMI, country of birth, smoking and SEIFA 5 , with further adjustment for co-morbidities. To test whether associations of steroids and SHBG with arthroplasty risk were modified by being overweight/ obese (BMI !25 kg/m 2 ), interactions were fitted, and tested using the likelihood ratio test.…”

“…Of the participants, 2590 (6.2%) were excluded because they: died or left Australia prior to 1 January 2001; reported at MCCS second follow-up having had any arthroplasty prior to 1 January 2001; left Australia before the recorded date of having a arthroplasty; or their first recorded procedure was a revision arthroplasty 5 . Of the remaining 38,924 participants, 15,655 were men.…”

“…This study examined the first total knee or hip arthroplasty with a contemporaneous diagnosis of OA 5 . If one person had multiple arthroplasties, the first recorded procedure was considered the event.…”

“…To better understand the pathogenesis of OA, the role of sex steroids in the development and progression of OA needs to be explored. OA could be defined using primary knee and hip arthroplasty due to severe knee and hip OA 5 . This approach is relevant to symptomatic disease burden and health economics.…”

Association between serum concentration of 25-hydroxyvitamin D and the risk of hip arthroplasty for osteoarthritis: result from a prospective cohort study

“…Moreover, these studies have used different methods to define hip OA, such as radiographic hip OA 11,12 , clinical examination by physicians 13 or the International Classification of Diseases codes 14 . One method for defining OA is to use arthroplasty, which identifies severe hip OA relevant to symptomatic disease burden and economic impact 16,17 . The aim of this prospective cohort study was to determine whether serum 25(OH)D concentrations were associated with the risk of hip arthroplasty for OA in a large cohort of Australian adults.…”