Incidence of thyroid gland invasion in advanced laryngeal cancers and its impact on disease-specific survival; a retrospective review at a tertiary care center

Muhammad, Tahir; Dhanani, Rahim; Mohtasham, Sameen; Hussain, Muntazir; Faisal, Muhammad; Malik, Kashif; Jamshed, Arif; Hussain, Raza

doi:10.1080/00016489.2020.1778786

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Likewise, Semdaie et al 25 advised against performing tracheotomy in case of dyspnea and, like ourselves, prefer CO 2 laser endolaryngeal debulking, in view of the greater perineural tumor infiltration associated with prior tracheotomy, jeopardizing the resection margins. Thyroid resection performed in 43% of the present cases, during TL, had no impact on local recurrence (Table II) and like several authors 26–32 focusing on the issue, we believe that, in endolaryngeal cT3‐4 SCC, thyroid resection is indicated mainly for transglottic or subglottic tumor and/or if subglottic extension exceeds 10 mm and/or involves the cricothyroid membrane. In a meta‐analysis in 2009, Mendelson et al 26 reported 8% thyroid gland involvement by endolaryngeal SCC treated by TL, making direct contiguity the main mechanism of thyroid involvement.…”

Section: Discussionsupporting

confidence: 69%

“…The first two concern the single-center and retrospective design, a limitation however found in almost all the 21st century literature on TL. [8][9][10][11]18,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] The third, and doubtless most important, point concerns to a variety of treatments detailed in the section describing the study population (Table I), with TL performed by 54 different headand-neck surgeons (see Acknowledgments) over a period of 4 decades. However, the local recurrence rate seemed not to vary from decade to decade (Table II), relativizing this bias and suggesting that oncologic results, and notably local recurrence, after TL for endolaryngeal cT3-4 SCC are not operator-dependent.…”

Section: Discussionmentioning

confidence: 99%

“…Like all reports following the STROBE guideline, 12 this discussion ends with study biases and three points limiting the scope of our conclusions. The first two concern the single‐center and retrospective design, a limitation however found in almost all the 21st century literature on TL 8–11,18,21–34 . The third, and doubtless most important, point concerns to a variety of treatments detailed in the section describing the study population (Table I), with TL performed by 54 different head‐and‐neck surgeons (see Acknowledgments) over a period of 4 decades.…”

Section: Discussionmentioning

confidence: 99%

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Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Laccourreye,

Garcia,

Haroun

et al. 2023

The Laryngoscope

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ObjectivesTo document 10‐year oncologic outcome of primary total laryngectomy (TL) for patients with cT3‐4M0 endolaryngeal squamous cell carcinoma (SCC).Study DesignObservational inception cohort of 531 patients with isolated untreated endolaryngeal cT3‐4M0 SCC review over 40 years using STROBE guideline. 94% of patients were followed until death or for a minimum of 10 years.SettingAcademic tertiary referral care center.MethodsAll patients underwent primary TL. Prior tracheotomy, induction chemotherapy, thyroid gland resection, level II‐IV neck dissection, level VI dissection, and postoperative radiation therapy were associated in 6%, 40%, 43%, 89%, 47%, and 74% of cases, respectively: The main objective was to determine the 10‐year actuarial local control estimate. Accessory objectives comprised screening for clinical variables increasing the risk of local recurrence, and analysis of long‐term oncologic consequences of local recurrence.ResultsThe 10‐year actuarial local control estimate was 89.7%. Local recurrence was salvaged in 11% of cases, resulting in 92% overall local control. On multivariate analysis, none of the study variables correlated with local recurrence. Local recurrence resulted in significantly reduced nodal control, distant metastasis control, and survival. Postoperative complications, persistent index SCC, intercurrent disease, and metachronous second primary cancer accounted for respectively 3%, 37%, 33%, and 28% of the 334 deaths noted during the 10 years following TL.ConclusionThe present study underscored the long‐term oncologic efficacy of primary TL, the dangers of local recurrence, the key role of local control for survival, and the importance of a long‐term oncologic watch policy.Level of Evidence3 Laryngoscope, 2023

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Laccourreye,

Garcia,

Haroun

et al. 2023

The Laryngoscope

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“…In the absence of thyroid gland involvement by tumor, both of the thyroid lobes can be preserved 10 . Now a few studies denote the factors upon which thyroid gland invasion in laryngeal Squamous cell carcinomas can be predicted 4,6 . These factors include preoperative assessment based on 1.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Novel Treatment of Thyroid Gland in Patients with Advance Carcinoma Larynx

Haider¹,

Aziz²,

Wahab³

et al. 2022

PJMHS

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Background: Among the carcinomas Head and Neck surgeon encounter, carcinoma larynx is amongst the most commons. Thyroid gland is close to larynx so is its risk to be involved by laryngeal malignancies. Removing whole or part of thyroid gland may put the patient at risk of permanent or temporary hypothyroidism and hypoparathyroidism. In recent past a number of risk factors are nominated to predict invasion of thyroid gland by laryngeal malignancies. So, there is a need to re-consider the management of thyroid gland in total laryngectomy. Aim: To justify the management of thyroid gland in advance carcinoma larynx. Study design: The study is cross sectional Randomized Control Trial. Place and duration of study: We conducted this study in ENT Unit I of Jinnah Hospital Lahore from June 2021 to May 2022. Methodology: A total of 20 patients were included in this study and were randomly divided into two groups on the basis of management of thyroid gland. Group A underwent hemi thyroidectomy while thyroid sparing total laryngectomy was done in group B. Histological evaluation of thyroid Gland was done in group A in addition to analysis of local recurrence in both Groups. Mean duration of follow-up was 6 months. Data analysis was done by using SPSS software and is presented in tabulated forms as percentages. Results: The study showed that thyroid gland was not involved in all cases of advance laryngeal malignancies thus obviating the need of total or hemithyroidectomy in all patients with advance Squamous Cell Carcinoma Larynx. Practical implication: All the cases of advance laryngeal malignancies used to undergo total or at least hemithyroidectomy as bystander of total laryngectomy. This study helps the surgeon decide whether a patient with proven laryngeal malignancy needs thyroid gland manipulation or not, thus decreasing the morbidity of the patient and improving cost effectiveness. Conclusion: This study made us reach to the conclusion that in patients with Grade I and II SCC, with no clinical or radiological involvement of thyroid and cricoid cartilage, thyroid gland, strap muscles or skin, there is no need for manipulation of thyroid gland in patients undergoing total Laryngectomy. Keywords: Laryngeal Carcinoma, Thyroid Gland management, Total Laryngectomy with Hemi thyroidectomy,

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“…Surgical treatments are often applied for early LSCC, including total laryngectomy, partial laryngectomy, oral laser microsurgery, etc., quickly removing the lesions and effectively controlling the disease. [5] Unfortunately, the early symptoms of LSCC are not significant, and most patients are diagnosed in stage III or IV. [6] At this stage, the treatment effect of patients is not satisfactory to a certain extent.…”

Section: Introductionmentioning

confidence: 99%

The analysis of tumor-infiltrating immune cell and ceRNA networks in laryngeal squamous cell carcinoma

Dong

et al. 2022

Medicine

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Background: Laryngeal squamous cell carcinoma (LSCC) is one of the most common forms of head and neck cancers. However, few studies have focused on the correlation between competing endogenous RNA (ceRNAs) and immune cells in LSCC.Methods: RNAseq expression of LSCC and adjacent tissues were downloaded from The Cancer Genome Atlas to establish a ceRNA network. The key gene in ceRNA was screened by the cox regression analysis to establish a prognostic risk assessment model. The CIBERSORT algorithm was then used to screen important tumor-infiltrating cells related to LSCC. Finally, co-expression analysis was applied to explore the relationship between key genes in the ceRNA network and tumor-infiltrating cells. The external datasets were used to validate critical biomarkers.Results: We constructed a prognostic risk assessment model of key genes in the ceRNA network. As it turned out, Kaplan-Meier survival analysis showed significant differences in overall survival rates between high-risk and low-risk groups (P < .001). The survival rate of the high-risk group was drastically lower than that of the low-risk group, and the AUC of 1 year, 3 years, and 5 years were all above 0.7. In addition, some immune infiltrating cells were also found to be related to LSCC. In the co-expression analysis, there is a negative correlation between plasma cells and TUBB3 (r = −0.33, P = .0013). External dataset validation also supports this result. Conclusion:In this study, we found that some key genes (SLC35C1, CLDN23, HOXB7, STC2, TMEM158, TNFRSF4, TUBB3) and immune cells (plasma cells) may correspond to the prognosis of LSCC.Abbreviations: ceRNA = competing endogenous RNA, DElncRNAs = differentially expressed lncRNAs, DEmRNAs = differentially expressed mRNAs, GEO = Gene Expression Omnibus, GO = Gene Ontology, HNSCC = head and neck squamous cell carcinoma, KEGG = Kyoto Encyclopedia of Genes and Genomes, LSCC = laryngeal squamous cell carcinoma, OS = overall survival, TCGA = The Cancer Genome Atlas.

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Incidence of thyroid gland invasion in advanced laryngeal cancers and its impact on disease-specific survival; a retrospective review at a tertiary care center

Cited by 7 publications

References 16 publications

Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Primary Total Laryngectomy for Endolaryngeal cT3‐4M0 Squamous Cell Carcinoma: A STROBE Analysis

Outcome of Novel Treatment of Thyroid Gland in Patients with Advance Carcinoma Larynx

The analysis of tumor-infiltrating immune cell and ceRNA networks in laryngeal squamous cell carcinoma

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