Incidence of Thrombocytopenia in Idiopathic Hyperbilirubinemic Newborns

Boskabadi, Hassan; Mafinezhad, Shahin; Bagher, Fatemah; Bozorgnia, Yasaman

doi:10.3889/oamjms.2014.043

Cited by 3 publications

(7 citation statements)

References 8 publications

(4 reference statements)

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“…5 In another study conducted 86.4% of neonates had mild thrombocytopenia while moderate and severe thrombocytopenia was seen in 14.6% of babies. 6 Our study didn't observe any significant difference in incidence of thrombocytopenia as far as gender was concerned which is comparable to the study. 5 This study observed that preterm babies who received phototherapy had significantly higher incidence of thrombocytopenia than term babies which was in comparison with the study.…”

Section: Discussionsupporting

confidence: 84%

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Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Shah¹,

Vedula²,

Roshan

2019

Int J Res Med Sci

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Background: Thrombocytopenia as a side effect of phototherapy has not been mentioned in the standard literature but was described briefly as isolated case reports after the phototherapy came in vogue in 1958. The purpose of this study was to find the incidence of thrombocytopenia in neonates with uncomplicated indirect hyperbilirubinemia receiving phototherapy in a referral hospital.Methods: This was a prospective cohort study conducted in a referral hospital over a period of 18 months from June 1, 2013 to November 1, 2014.Results: A total of 103 babies were enrolled. The overall incidence of post-phototherapy thrombocytopenia was 45.6% while mild, moderate and severe thrombocytopenia was present in 66%, 21.3% and 12.8% of babies respectively. The lowest platelet count observed was 31,000/mm3 but none of the neonates showed bleeding manifestations. The incidence of thrombocytopenia following phototherapy was significantly higher in preterm babies, infants who received double surface phototherapy, babies who received phototherapy for >72 hours and in babies who received phototherapy on day 2 or 3 of life.Conclusions: Neonates requiring phototherapy for hyperbilirubinemia are at risk of developing thrombocytopenia, hence the treatment should be initiated based on the standard guidelines. Unnecessary use and prolongation of phototherapy should be avoided considering the possible side effects. Platelet count should be monitored particularly in pre-term neonates receiving phototherapy. Neonates receiving double surface phototherapy and those requiring phototherapy for longer duration require more frequent platelet count monitoring.

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Section: Discussionsupporting

confidence: 84%

“…This finding was in contrast to the studies; however, their results were not statistically significant. 5,6,7,8…”

Section: Discussionmentioning

confidence: 99%

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Shah¹,

Vedula²,

Roshan

2019

Int J Res Med Sci

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“…3,4 Another study conducted by Boskabadi et al on incidence of thrombocytopenia in idiopathic hyperbilirubinemic newborns also showed that 86.4% of babies with NNH had mild thrombocytopenia. 22 In a study conducted by Khera et al on incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates, an association of phototherapy as a cause of thrombocytopenia in hyperbilirubinemic neonates was established. 23 Zieve et al demonstrated effects of high intensity white light on human platelets in vitro.…”

Section: Neonatal Factorsmentioning

confidence: 99%

Study of risk factors of neonatal thrombocytopenia

Tirupathi

Swarnkar

Vagha

2016

Int J Contemp Pediatr

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Background: Neonatal thrombocytopenia (platelet count < 1.5 lac/µl) is the commonest haematological abnormality encountered in neonatal intensive care unit (NICU). Thrombocytopenia if not detected can result in devastating complications. Determining the risk factors of thrombocytopenia enables us to prevent the inevitable and irreversible complications. The present study highlights the pattern, severity and risk factors of neonatal thrombocytopenia in our hospital.Methods: Prospective observational study was conducted on 200 neonates with thrombocytopenia admitted in NICU of our hospital. Maternal and neonatal risk factors were recorded. Neonates were grouped based on the severity of thrombocytopenia. The risk factors were compared with severity of thrombocytopenia.Results: 200 neonates with thrombocytopenia were divided into three groups based on severity of thrombocytopenia. 81% of babies had moderate to severe thrombocytopenia. The most common maternal predisposing factors were pregnancy induced hypertension (PIH), premature rupture of membranes (PROM) and anemia.62.5% babies were low birth weight babies and they had severe thrombocytopenia. 56% babies had late onset neonatal thrombocytopenia and 44% had early onset thrombocytopenia. The most common neonatal risk factors were sepsis in 48.5% babies and birth asphyxia in 20% babies.Conclusions: The severity of neonatal thrombocytopenia in our NICU was moderate to severe type. PIH, PROM and anemia were the commonest maternal risk factors. Preterm and low birth weight babies had severe thrombocytopenia. Sepsis and birth asphyxia were the commonest neonatal risk factors. Birth asphyxia was associated with early onset neonatal thrombocytopenia and sepsis was associated with late onset thrombocytopenia. Severe thrombocytopenia can be used as a prognostic indicator in sick neonates.

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“…The kernicterus manifests as devastating permanent brain injury leading eventually to permanent brain retardation. [3][4][5] The NH occurs because of imbalance of liver functioning due to immaturity and increased bilirubin load to detoxify. This results in lagging behind of bilirubin in capillaries giving an appearance of yellowness (jaundice).…”

Section: Introductionmentioning

confidence: 99%

“…However, many adverse effects have been reported in the medical literature. [3][4][5][6] Reported side effects of PT are; dehydration due to insensible water loss, hyperthermia, skin rash, retinal damage, loose stool, hypocalcemia, risk of patent ductus arteriosus, hypocalcemia, skin damage, and genotoxicity. 8,9 Previous human studies [8][9][10] suggested phototherapy causes the low blood platelet counts called the thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

Phototherapy in full term neonates suffering from unconjugated hyperbilirubinemia; Does it affect platelet count?

Bashir¹,

Kumar²,

Maheshwari³

et al. 2020

TPMJ

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Objectives: Investigating the hazardous effect of Phototherapy on Platelet counts in healthy neonates with Neonatal hyperbilirubinemia (NH). Study Design: Cross Sectional study. Setting: Department of Paediatrics, SMBB Medical College Layari General Hospital, Karachi, Sindh. Period: January 2018 to May 2019. Material & Methods: A sample of 313 neonates suffering from NH was selected according to the inclusion and exclusion criteria. Blood Platelets were counted at baseline, and 24, 48 and 72 hours of phototherapy. Statistical software SPSS 21.0 (IBM, Incorp, USA) was used for data analysis using paired t-test and Pearson`s Chi- square test at P≤0.05. Results: Platelet counts at 24, 48 and 72 hours of phototherapy were found 2.97±0.45×109/L, 3.38±0.48×109/L and 3.52± 0.47×109/L respectively. Platelet counts at 24, 48 and 72 hours showed statistically significant difference compared to baseline counts (P<0.05). A statistically insignificant decline in total population platelet count after phototherapy was noted (P>0.05). However, thrombocytopenia was noted in 9 (2.87%) cases; comprising mild and moderate in 7 (2.23%) and 2 (0.64%) cases respectively. Conclusion: The present study observed thrombocytopenia in 9 (2.87%) of total cases; of which mild and moderate thrombocytopenia occurred in 7 (2.23%) and 2 (0.64%) cases respectively.

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Incidence of Thrombocytopenia in Idiopathic Hyperbilirubinemic Newborns

Cited by 3 publications

References 8 publications

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Study of risk factors of neonatal thrombocytopenia

Phototherapy in full term neonates suffering from unconjugated hyperbilirubinemia; Does it affect platelet count?

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