Incidence of thin membrane nephropathy: morphometric investigation of a population sample.

Abstract

To explore the incidence of thin mem-

Thin Basement Membrane Nephropathy

“…Conversely, nephrotic-range proteinuria is rare even in older patients. Renal function in children with TBMN is normal (43,49,60), whereas adults have been reported to have low prevalence of renal insufficiency (16,17,26,27,46,47,61). The incidence of renal insufficiency in these patients might partially reflect the complicated differential diagnosis from autosomal or X-linked Alport syndrome or concurrent additional renal disease.…”

“…The characteristic clinical manifestation of TBMN is persistent microscopic hematuria (1)(2)(3)8,11,16,17,26,27,43,44,46,57). Most patients with TBMN present only with hematuria, without additional symptoms or progression to renal impairment, and the condition is usually incidentally detected during health control.…”

The Many Faces of Thin Basement Membrane Nephropathy; A Population Based Study

“…Although a common nephropathy, the incidence of TBMN is poorly defined and estimates vary widely in the literature from 1% to 9% (Tryggvason & Patrakka, 2006), (Dische et al, 1990). Using electron microscopy in conjunction with a direct quantitative technique for measuring GBM thickness we recently estimated the incidence of TBMN to be 5.4% in the Cypriot population (Zouvani et al, 2008).…”

A Case of IgA Nephropathy in Three Sisters with Thin Basement Membrane Disease

“…The incidence of thin basement membrane disease in the general population lies between 5.2 and 9.2% [9]. A condition characterized by a GBM that is considerably thinner than normal was first reported by Rogers et al [10].…”

“…A condition characterized by a GBM that is considerably thinner than normal was first reported by Rogers et al [10]. Thin basement membrane disease is solely defined by thinning of the GBM ranging from 150 nm [10] to 250 [8], 330 [9] and less than 250 nm in children [8].…”