Incidence of spread of clinically relevant SARS-CoV2 infection between children in a tertiary emergency department: An evaluation

Pandey, Mritunjay; Sisodia, Shilpa; Bandi, Srini; Roland, Damian

doi:10.1016/j.jinf.2020.09.020

Journal of Infection

2020

DOI: 10.1016/j.jinf.2020.09.020

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Incidence of spread of clinically relevant SARS-CoV2 infection between children in a tertiary emergency department: An evaluation

Mritunjay Pandey

Shilpa Sisodia

Srini Bandi

et al.

Abstract: Incidence of spread of clinically relevant SARS-CoV2 infection between children in a tertiary emergency department: An evaluation ✩

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Cited by 2 publications

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“…There is a risk of a type 2 error of interpretation due to the relatively small sample size, but the complete absence of positive results lead us to believe this is unlikely. Our department has previously demonstrated an overall very low rate of SARS-CoV-2 in admitted children that would support these findings 2. Our conclusion also presumes a similar asthma severity phenotype each year that we believe is a reasonable assumption due to the very similar numbers of presentations and outcomes across years.…”

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confidence: 77%

COVID-19 is not a driver of clinically significant viral wheeze and asthma

et al. 2020

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supporting

confidence: 77%

COVID-19 is not a driver of clinically significant viral wheeze and asthma

et al. 2020

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Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis

Kulkarni,

Ismail,

Zhu

et al. 2024

J Glob Health

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Methods We searched MEDLINE, Embase, Global Health, CINAHL, China National Knowledge Infrastructure, Wanfang, CQvip, and the World Health Organization (WHO) COVID-19 global literature databases for primary studies recruiting children aged ≤18 years with a diagnosis of SARS-CoV-2 infection confirmed either by molecular or antigen tests. We used the Joanna Briggs Institute critical appraisal tools to appraise the study quality and conducted meta-analyses using the random effects model for all outcomes except for race/ethnicity as risk factors of SARS-CoV-2 infection. Results We included 237 studies, each reporting at least one of the study outcomes. Based on data from 117 studies, the pooled SARS-CoV-2 positivity rate was 9.30% (95% confidence interval (CI) = 7.15–11.73). Having a comorbidity was identified as a risk factor for SARS-CoV-2 infection (risk ratio (RR) = 1.33; 95% CI = 1.04–1.71) based on data from 49 studies. Most cases in this review presented with mild disease (n = 50; 52.47% (95% CI = 44.03–60.84)). However, 20.70% of paediatric SARS-CoV-2 infections were hospitalised (67 studies), 7.19% required oxygen support (57 studies), 4.26% required intensive care (93 studies), and 2.92% required assisted ventilation (63 studies). The case fatality ratio (n = 119) was 0.87% (95% CI = 0.54–1.28), which included in-hospital and out-of-hospital deaths. Conclusions Our data showed that children were at risk for SARS-CoV-2 infections and severe outcomes in the pre-Omicron era. These findings underscore the need for effective vaccination strategies for the paediatric population to protect against the acute and long-term sequelae of COVID-19. Registration PROSPERO: CRD42022327680.

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Incidence of spread of clinically relevant SARS-CoV2 infection between children in a tertiary emergency department: An evaluation

Abstract: Incidence of spread of clinically relevant SARS-CoV2 infection between children in a tertiary emergency department: An evaluation ✩

Cited by 2 publications

References 3 publications

COVID-19 is not a driver of clinically significant viral wheeze and asthma

COVID-19 is not a driver of clinically significant viral wheeze and asthma

Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis

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