Incidence of Spondyloarthropathy in Patients with Ulcerative Colitis: A Population-based Study

Shivashankar, Raina; Loftus, Edward V.; Harmsen, William S.; Zinsmeister, Alan R.; Matteson, Eric L.

doi:10.3899/jrheum.121029

Cited by 28 publications

(19 citation statements)

References 20 publications

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“…Incidence and prevalence of SpA has been reviewed recently, but there are very few data available on the prevalence of IBD‐related SpA and to our knowledge, none on SpA manifestations of IBD patients on TNF inhibitors. One recent study with a cohort including 365 ulcerative colitis patients, of whom 40 developed spondyloarthropathy, found that the cumulative prevalence of all forms of SpA increased from 4.8% at 10 years to 13.7% at 20 years and 22% at 30 years after the diagnosis of ulcerative colitis . This value was slightly greater than what had previously been described in a patient‐based cohort of Crohn disease diagnosed over the same time period …”

Section: Discussionmentioning

confidence: 73%

Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors

Subramaniam

Tymms

Shadbolt

et al. 2015

Internal Medicine Journal

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Section: Discussionmentioning

confidence: 73%

Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors

Subramaniam

Tymms

Shadbolt

et al. 2015

Internal Medicine Journal

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“…9 Nevertheless, the prevalence of spondyloarthritis in IBD is reported from several cohorts outside the USA, 10 – 14 and one study from Olmsted County, Minnesota, estimated that the cumulative incidence of spondyloarthritis among patients with IBD after 10 years was 6.7% [95% confidence interval (CI) 2.5%–6.7%]. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

Characterization and prevalence of spondyloarthritis and peripheral arthritis among patients with inflammatory bowel disease

Malaty¹,

Lo²,

Hou³

2017

CEG

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BackgroundJoint complaints such as spondyloarthritis and peripheral arthritis are the most common extraintestinal manifestations in patients with inflammatory bowel disease (IBD); however, the evaluation of these symptoms are poorly described.ObjectivesTo examine the clinical characteristics and prevalence of ankylosing spondylitis (AS) and other joint complaints among patients with IBD.MethodsIn a local cohort of patients diagnosed with IBD between 1996 and 2009, we performed a retrospective study at the Veterans Affairs Hospital. Patients with IBD were identified by International Classification of Diseases, Ninth Revision codes and confirmed by chart review. The occurrence of AS, peripheral arthritis, and other peripheral and axial joint symptoms were identified.ResultsWe identified 626 patients with IBD between ages 18 and 90 (90% males), of whom 57% had ulcerative colitis (UC), 74% were Caucasians, and the mean age at diagnosis was 54 (±16) years. Among the study population, 108 patients (17%) had at least one type of joint pain. Among these 17% with joint pain, 12% had AS, 43% had peripheral arthritis, 32% had chronic back pain without AS, and 13% had other types of joint pain. The overall prevalence of peripheral arthritis among patients with IBD was three times higher than that of AS (7% vs 2.1%, respectively, OR 3.5; 95% confidence interval [CI] 1.9–6.5; p=0.001). There was no difference in the prevalence of AS or peripheral arthritis between patients with Crohn’s disease and UC. The initial diagnosis of AS occurred after the initial diagnosis of IBD in 80% of patients within a mean (SD) period of 5.6 (±6) years.ConclusionSpondyloarthritis among patients with IBD is usually diagnosed after the initial diagnosis of IBD. No difference in the prevalence of AS or peripheral arthritis was observed by IBD type, age, or race. Recognition and understanding of these results will have important implications for the management of IBD patients with spondyloarthritis.

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“…Spondyloarthropathy is divisible in humans to five varieties [1,2,66]. One is associated with the skin disease, psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Recognition and Breed Specificity of Canine Spondyloarthropathy

Rothschild¹,

Breit²

2016

J Spine

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Human diseases sometimes represented across phylogenetic lines. Their recognition is at times compromised by differential (between human and veterinary medicine) use of diagnostic terms. A major impetus to such change is recognition of additional treatment options that would not be considered for the replaced diagnosis/category. Canine syndesmophytes are recognized as identifier for spondyloarthropathy. This study examines the breed-specificity of those changes.The axial skeletons and peripheral joints (when available) of 1323 dogs, identified to breed, were examined for evidence of syndesmophytes and sacroiliac joint disease.Syndesmophytes were found in 315 of 1323 axial skeletons examined, extremely common in Boxer and German Shephard; rare, in Beagle, Chihauahua, Dachshund, Maltese and Pug. First noted at 2 years of age, its prevalence increased geometrically over the next 13 years. All affected individuals weighed more than 2 kilograms and prevalence increased geometrically through 39.9 kilograms. Spondyloarthropathy was present in 17.3% of brachycephalic, contrasted with 35.0% of mesticephalic dogs [Chi square = 16.972, p < 0.0001].Presence of syndesmophytes identified the underlying arthritis as spondyloarthropathy, not osteoarthritis. Recognition of the vertebral findings as characteristic of this inflammatory arthritis affords an opportunity for controlling the disease process and improving quality of life of the afflicted dog.

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Incidence of Spondyloarthropathy in Patients with Ulcerative Colitis: A Population-based Study

Cited by 28 publications

References 20 publications

Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors

Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors

Characterization and prevalence of spondyloarthritis and peripheral arthritis among patients with inflammatory bowel disease

Recognition and Breed Specificity of Canine Spondyloarthropathy

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