Incidence of side effects of topical atropine sulfate and cyclopentolate hydrochloride for cycloplegia in Japanese children: a multicenter study

Wakayama, Akatsuki; Nishina, Sachiko; Miki, Atsushi; Utsumi, Takashi; Sugasawa, Jun; Hayashi, Takao; Sato, M.; Kimura, Akiko; Fujikado, Takashi

doi:10.1007/s10384-018-0612-7

Cited by 42 publications

(37 citation statements)

References 14 publications

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“…Shanker and Nigam [9] administered 1% atropine twice a day for 1 week with punctual occlusion to relax the accommodation of a patient with the spasm of near reflex. However, Wakayama et al [10] reported a higher incidence of adverse effect with 1% atropine compared to 0.5 and 0.25%. Hence, we decreased the concentration due to the prolonged use of atropine in our patient.…”

Section: Discussionmentioning

confidence: 97%

Combined Interventions for Nonorganic Visual Loss in a Case with Pseudo-Myopia: A Perspective from Vietnam

Nguyen¹,

Hoang

Tran³

et al. 2020

Case Rep Ophthalmol

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A previously healthy 10-year-old girl developed painless visual loss. She was diagnosed with a spasm of accommodation confirmed by cycloplegic refraction. She was prescribed low-dose atropine and again reported acute visual loss that was inconsistent with the level of daily function. She was referred to a pediatric psychiatrist with suspicion for a nonorganic visual disorder and was diagnosed with conversion disorder. She received psychotherapy and continued the treatment with low-dose atropine. Her visual acuity at distance returned to normal. Psychogenic visual loss can mimic organic disorders; hence, ophthalmologists should be aware of cases without the agreement between visual signs and daily manifestation.

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Section: Discussionmentioning

confidence: 97%

Combined Interventions for Nonorganic Visual Loss in a Case with Pseudo-Myopia: A Perspective from Vietnam

Nguyen¹,

Hoang

Tran³

et al. 2020

Case Rep Ophthalmol

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“…This phenomenon often develops into a high fever known as ‘atropine fever’ [ 8 , 9 ]. The frequency of ophthalmic atropine drop-induced fever in children has been reported at 1.3% (2/160) [ 7 ], 3.9% (32/811) [ 10 ], 4.0% (13/326) [ 11 ], and 72.7% (48/66) [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Garg and Sinha [12] reported that in several children (6/66) in New Delhi, India, fever reached > 40 °C (no method of measurement was reported). Whereas the above reports [7, 8, 10–12] lacked detailed environmental descriptions, Magbagbeola [13] reported that in Ibadan, Nigeria, 58.5% (117/200) of children administered intramuscular injections of atropine as premedication for surgery had increased body temperature; the hospital ward had no air conditioning, an ambient temperature of 28.74 ± 0.13 °C, and a mean relative humidity of 71.59 ± 0.54%. That is to say, hot weather may be one of the risk factors for this type of hyperthermia.…”

Section: Discussionmentioning

confidence: 99%

Acute Exacerbation of Fever Following Administration of Tropicamide and Phenylephrine Ophthalmic Solution: A Case Report

Haba

Shiga

Naito

2019

Drug Saf - Case Rep

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A 24-year-old woman with atopic dermatitis and persistent fever (axillary temperature of 37–38 °C for 6 months) received combination ophthalmic drops containing tropicamide and phenylephrine (Mydrin ® -P), which exacerbated her fever within 15 min after instillation. Her axillary fever reached 40.1 °C but resolved the following day. No new dermatological symptoms developed. Although the patient’s fever may have been caused by either tropicamide or phenylephrine, neither of which have been reported to induce fever in topical formulations, atopic dermatitis and tropicamide’s inhibitory effect on perspiration under hot and humid conditions may have been the more probable cause. While drug-induced fever has been reported for other ophthalmic anticholinergic agents, this is the first reported case of possible fever exacerbation by an ophthalmic formulation of tropicamide, if the causative agent is assumed to be tropicamide.

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“…Atropine is the gold standard for evaluating cycloplegic refraction. 5,6 However, its long action, which results in prolonged blurred vision and a lengthy recovery time, has limited its application, particularly among elder children and adults. Besides atropine, the most commonly used cycloplegic agents are tropicamide and cyclopentolate.…”

Section: Introductionmentioning

confidence: 99%

<p>Anterior Segment Biometry During Accommodation and Effects of Cycloplegics by Swept-Source Optical Coherence Tomography</p>

Mitsukawa

Suzuki

Momota

et al. 2020

OPTH

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We analyzed changes in the crystalline lens during accommodation and the effects of cycloplegics by swept-source anterior-segment optical coherence tomography (AS-OCT). Materials and Methods: Twenty healthy volunteers (7 males and 13 females, aged 22-34 years), with no history of eye disease except for refractive errors, were recruited. Biometric parameters, including anterior chamber depth (ACD), lens thickness (LT), and anterior and posterior curvature of the lens (ACL and PCL), were measured using AS-OCT (CASIA2). The measurements were performed with or without an accommodative demand of 5.0 diopters (D). The same tests were repeated following the topical administration of 1% cyclopentolate or a compounding agent comprising 0.5% tropicamide and 0.5% phenylephrine. Results: The AS-OCT system was capable of simultaneous visualization of all optical components of the anterior segment in a single frame. ACD, LAC, and LPC decreased and LT increased significantly during 5.0 D accommodative stimulation in both eyes. Both cyclopentolate and tropicamide/phenylephrine eyedrops led to deeper ACD, thinner LT, and flatter LAC. There were no significant differences in all lens parameters despite having 5.0 D accommodative stimulation in both eyes with cycloplegia. Conclusion: Our results suggest that both tropicamide/phenylephrine and cyclopentolate eyedrops have enough cycloplegic effects in young adults.

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Incidence of side effects of topical atropine sulfate and cyclopentolate hydrochloride for cycloplegia in Japanese children: a multicenter study

Cited by 42 publications

References 14 publications

Combined Interventions for Nonorganic Visual Loss in a Case with Pseudo-Myopia: A Perspective from Vietnam

Combined Interventions for Nonorganic Visual Loss in a Case with Pseudo-Myopia: A Perspective from Vietnam

Acute Exacerbation of Fever Following Administration of Tropicamide and Phenylephrine Ophthalmic Solution: A Case Report

<p>Anterior Segment Biometry During Accommodation and Effects of Cycloplegics by Swept-Source Optical Coherence Tomography</p>

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