Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study

Lohmander, L. Stefan; Verdier, Maria Gerhardsson de; Rollof, Jan; Nilsson, Peter M.; Engström, Gunnar

doi:10.1136/ard.2008.089748

Cited by 329 publications

(289 citation statements)

References 38 publications

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“…Independent risk factors for this disorder include older age (12), female sex (13), obesity (13)(14)(15)(16), physical activity (12)(13)(14), and never having smoked (9,13,15). However, the reported association of some of these factors with an increased risk of OA or subsequent TJR has not been consistent.…”

Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 84%

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Mnatzaganian¹,

Ryan²,

Norman³

et al. 2011

Arthritis & Rheumatism

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Objective. To assess the associations of smoking, body weight, and physical activity with risk of undergoing total joint replacement (TJR) in a population-based cohort of men.Methods. A cohort study of 11,388 men that integrated clinical data with hospital morbidity data and mortality records was undertaken. The risk of undergoing TJR was modeled on baseline weight, height, comorbidity, socioeconomic status, years of smoking, and exercise in 3 separate age groups, using Cox proportional hazards regressions and competing risk regressions (CRRs).Results. Dose-response relationships between weight and risk of TJR and between smoking and risk of TJR were observed. Being overweight independently increased the risk of TJR, while smoking lowered the risk. The decreased risk among smokers was demonstrated in both Cox and CRR models and became apparent after 23 years of exposure. Men who were in the highest quartile (>48 years of smoking) were 42-51% less likely to undergo TJR than men who had never smoked. Tests for trend in the log hazard ratios (HRs) across both smoking and weight quantiles yielded significant P values. Vigorous exercise increased the hazard of TJR; however, the association reached statistical significance only in the 70-74-year-old age group (adjusted HR 1.64 [95% confidence interval 1.19-2.24]). Adjusting for Deyo-Charlson Index or Elixhauser's comorbidity measures did not eliminate these associations.Conclusion. Our findings indicate that being overweight and reporting vigorous physical activity increase the risk of TJR. This study is the first to demonstrate a strong inverse dose-response relationship between duration of smoking and risk of TJR. More research is needed to better understand the role of smoking in the pathogenesis of osteoarthritis.

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Section: -224]) Adjusting For Deyo-charlson Index or Elixhauser'smentioning

confidence: 84%

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Mnatzaganian¹,

Ryan²,

Norman³

et al. 2011

Arthritis & Rheumatism

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“…In adults, increasing body mass index (BMI) and obesity result in knee pain [19], progressive physical disability [5,18], diminished health-related quality of life [18], and a clear risk of development of knee osteoarthritis [7,24,47]. Recent evidence shows that obesity in young adulthood is associated with a threefold increase in knee osteoarthritis by age 60 years [4,14,26]. Musculoskeletal comorbidities have become a recent focus of research in obese children.…”

Section: Introductionmentioning

confidence: 99%

Lower Extremity Pain Is Associated With Reduced Function and Psychosocial Health in Obese Children

Bout-Tabaku

Briggs

Schmitt

2013

Clinical Orthopaedics &Amp; Related Research

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Background Childhood obesity is associated with reduced quality of life, physical fitness, and a higher prevalence of lower extremity (LE) pain; however, it is unclear whether and how these factors are related. Questions/purposes For this study we asked if obese children with LE pain (LE+) had higher BMI-Z scores, lower physical function and psychosocial health, and lower physical fitness compared with obese children without LE pain (LEÀ). We determined the association of BMI-Z score with physical function, psychosocial health, or physical fitness in obese children.

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“…We recently studied this topic for patients with hip arthritis [17]; however, it is important to evaluate it for knee OA separately, because primary OA in different joints may have a different phenotype and thus have different pathophysiological pathways. For example, high body fat is more strongly associated with knee OA than with hip OA [21]. Furthermore, different anthropometry may confer different pre-, peri-, and postoperative clinical implications.…”

Section: Introductionmentioning

confidence: 99%

Patients With Knee Osteoarthritis Have a Phenotype With Higher Bone Mass, Higher Fat Mass, and Lower Lean Body Mass

Karlsson

Magnusson

Cöster

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Although knee osteoarthritis (OA) is common, its etiology is poorly understood. Specifically, it is not known whether knee OA is associated with abnormal anthropometric and musculoskeletal characteristics known to be associated with OA in general. We recently studied this topic for patients with hip arthritis; however, it is important to evaluate it for knee OA separately, because there are reports indicating that patients with primary OA in different joints may have a different phenotype. Questions/purposes Do patients with primary knee OA have a phenotype with higher bone mineral density (BMD), higher body mass index (BMI), larger skeletal size, lower lean body mass, and higher fat content?Methods We included 38 women and 74 men (mean age, 61 years; range, 34-85 years) with primary knee OA and 122 women and 121 men as control subjects. We used dual-energy x-ray absorptiometry to measure total body BMD (g/cm 2 ), femoral neck width (cm), fat and lean mass (%), and BMI (kg/m 2 ). Z scores were calculated for each individual. Data are presented as means with 95% confidence intervals. Results Women with knee OA had the following Z scores: total body BMD 0.8 (0.5-1.0); BMI 1.6 (1.1-2.0); femoral neck width 0.1 (-0.3 to 0.4); proportion of lean mass -1.0 (-1.5 to -0.6); and proportion of fat mass 1.0 (0.6-1.4). Men with knee OA had the following Z scores: total body BMD 0.5 (0.3-0.7); BMI 0.9 (0.6-1

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Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study

Cited by 329 publications

References 38 publications

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population‐based cohort of men

Lower Extremity Pain Is Associated With Reduced Function and Psychosocial Health in Obese Children

Patients With Knee Osteoarthritis Have a Phenotype With Higher Bone Mass, Higher Fat Mass, and Lower Lean Body Mass

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