Incidence of second primary malignancy after breast cancer and related risk factors—Is breast‐conserving surgery safe? A nested case–control study

Li, Zhuyue; Wang, Kang; Shi, Yang; Zhang, Xuemei; Wen, Jin

doi:10.1002/ijc.32259

Cited by 31 publications

(39 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Our results showed that breast cancer as the second primary cancer was associated with short survival. The 5-year BCSS and OS rates were significantly lower in patients with breast cancer as the second primary cancer than in those with breast cancer as the prior cancer in both the standard and PSM analyses, these results are AGING Patients who received underwent chemotherapy for prior cancer may not respond well to systemic treatment for their second primary cancer due to decreased efficacy and tolerability after prior systemic treatment [33,34]. Interestingly, Fine and Gray's regression analysis showed that breast cancer treatment was associated with a decreased risk of BCSM.…”

Section: Discussionmentioning

confidence: 83%

Risk of breast cancer-related death in women with a prior cancer

Yang

et al. 2020

Aging

View full text Add to dashboard Cite

The overall risk of developing a second primary cancer is increasing. The purpose of this study was to analyze the survival of patients with breast cancer diagnosed after a prior cancer and identify risk factors of breast cancer death in this population. Using the SEER database, we identified 1,310 woman diagnosed with breast cancer between 2010 and 2015 after a prior cancer as the primary cohort. Clinicopathological characteristics were compared using the Student t-test and chi-square test. Fine and Gray's regression was used to evaluate the effect of treatments on breast cancer death. After propensity score matching (PSM), 9,845 pairs of patients with breast cancer as the prior or second cancer diagnosed between 2010 and 2011 were included as a second cohort. PSM-adjusted Kaplan-Meier and Cox hazards models were used to evaluate the impact of prior cancer on survival. The results showed that survivors of gynecologic cancers (e.g., ovarian cancer) had a higher risk of developing breast cancer than survivors of gastrointestinal and urinary tract cancers. More patients died of breast cancer than of prior urinary cancer (53.3% vs. 40%, P < 0.05) and melanoma (66.7% vs. 33.3%, P < 0.05). The ratio of breast cancer deaths to prior cancer deaths was significantly higher in patients with diagnoses interval ≥ 3 years than in those with the interval < 3 years (2.67 vs. 0.69, P < 0.001). Breast cancer-specific survival and overall survival rates were significantly lower in women with breast cancer as the second primary cancer than in those with breast cancer as the prior cancer, especially among hormone receptor-positive women. However, breast cancer treatment decreased the risk of breast cancer -specific death (hazard ratio = 0.695, 95% confidence interval: 0.586-0.725, P < 0.001). Breast cancer patients with prior cancers must be carefully considered for clinical trials.

show abstract

Section: Discussionmentioning

confidence: 83%

Risk of breast cancer-related death in women with a prior cancer

Yang

et al. 2020

Aging

View full text Add to dashboard Cite

show abstract

“…Nevertheless, breast-conserving surgery (BCS) has some limitations in clinical practice, and the need for radiotherapy after surgery causes many patients to lose their motivation for BCS [8,9]. On the other hand, traditional modified radical mastectomy (MRM) significantly increases the occurrence of complications such as upper limb edema and paraesthesia, and the surgical scar from on the chest and the axilla will affect the esthetics and limit the movement of the shoulder joint to some extent [10].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of modified radical mastectomy with nipple-areola preservation combined with stage I prosthesis implantation using air cavity-free suspension hook in patients with breast cancer

Liu

et al. 2021

World J Surg Onc

View full text Add to dashboard Cite

Background Mastoscopic surgery is proven to have lower incidence of postoperative complications and better postoperative recovery than traditional breast cancer surgery. This study aimed to examine the feasibility of mastoscopic modified radical mastectomy (MRM) with skin nipple-areola preservation under air cavity-free suspension hook and stage I silicone prosthesis implantation (SMALND) compared with routine MRM. Methods This was a retrospective study of patients who underwent MRM for breast cancer at the Shengjing Hospital Affiliated to China Medical University between January 1, 2019, and June 30, 2019. Surgical outcomes, complications, satisfaction, and quality of life (Functional Assessment of Cancer Therapy-Breast [FACT-B] [Chinese version]) were compared between the two groups. Results A total of 87 patients were enrolled, with 30 underwent SMALND and 57 underwent routine MRM. The intraoperative blood loss in the SMALND group was lower than in the control group (165.3±44.1 vs. 201.4±52.7 ml, P=0.001), the operation time was longer (220.5±23.9 vs. 155.6±9.2 min, P<0.001), daily axillary drainage volume was smaller (20.2±3.6 vs. 24.1±3.0 ml, P<0.001), daily subcutaneous drainage volume was smaller (15.5±2.3 vs. 19.3±3.5 ml, P<0.001), the discharge time was shorter (7.5±1.6 vs. 9.0±1.8 days, P<0.001), and FACT-B scores were higher (83.8±5.6 vs. 72.1±4.6, P<0.001). The overall satisfaction was higher in the SMALND group than in the controls (76.7% vs. 54.4%, P=0.041). Compared with the controls, the occurrence rates of nipple and flap necrosis, upper limb edema, and paraesthesia in the SMALND group were lower within 6 months (all P<0.05). Conclusions Compared with traditional MRM, SMALND had better surgical outcomes, higher satisfaction, higher quality of life, and lower complication rates.

show abstract

“…Previous studies reported a greater risk of MPC among patients with an initial diagnosis of breast cancer at the age of < 50 years and in Black women with an ER-/PR-status than in Other patients [10] . A clinical study reported that the use of systemic therapy did not increase the risk of MPC [11] , while a nested case-control study using the SEER database suggested that radiotherapy (HR = 1.33) was related to the risk of second primary malignancy after BC [12] .…”

Section: Introductionmentioning

confidence: 99%

Multiple Primary Cancer and Survival after Lumpectomy with or without Radiotherapy for Ductal Carcinoma in Situ: A Propensity Score Matching Case-Control Study

Li¹,

Ouyang²,

Chen³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Radiotherapy combined with breast-conserving surgery is widely performed in patients with ductal carcinoma in situ (DCIS). This research was conducted to evaluate the use of radiotherapy to reduce the risk of MPC and mortality in DCIS patients.Methods: 128,416 patients first diagnosed with DCIS between 1998 and 2015 who received lumpectomy in the Surveillance, Epidemiology, and End Results (SEER) 18 database were included. Information on age, race, year of diagnosis, laterality, pathologic grade, surgery, radiation, estrogen receptor status, progesterone receptor status, tumor size and vital status was extracted. A comparison of lumpectomy alone vs. lumpectomy plus radiotherapy was performed using 1:1 propensity score-based matching.Results: Of the 128,416 patients with DCIS, 39,039 patients were treated with lumpectomy alone, and 69,377 were treated with lumpectomy and radiotherapy. The adjusted hazard ratio (HR) for death was 0.801 (95%CI: 0.7728-0.8301) and 0.7444 (95%CI: 0.7139-0.7761) for occurrence of MPC in the lumpectomy and radiotherapy vs. lumpectomy alone groups, respectively. Radiotherapy decreased the standardized incidence ratio (SIR) of MPC from 1.36 to 1.34. The incidence rate of a second breast cancer was reduced by 1.83% with radiotherapy (from 5.93% (2,177/36,688) to 4.10% (1,504/36,688)) in the matched cohort. Conclusion: Lumpectomy plus radiotherapy is associated with a significant reduction in mortality and risk of MPC, mainly second primary BC. Of those patients younger than 40 years, Black women with high-grade tumors were likely to benefit most. Radiotherapy reduced the risk of occurrence rather than the mortality of MPC patients to reduce the overall mortality.

show abstract

Incidence of second primary malignancy after breast cancer and related risk factors—Is breast‐conserving surgery safe? A nested case–control study

Cited by 31 publications

References 41 publications

Risk of breast cancer-related death in women with a prior cancer

Risk of breast cancer-related death in women with a prior cancer

Feasibility of modified radical mastectomy with nipple-areola preservation combined with stage I prosthesis implantation using air cavity-free suspension hook in patients with breast cancer

Multiple Primary Cancer and Survival after Lumpectomy with or without Radiotherapy for Ductal Carcinoma in Situ: A Propensity Score Matching Case-Control Study

Contact Info

Product

Resources

About