Incidence of Second Primary Cancers in Osaka Residents, Japan, with Special Reference to Cumulative and Relative Risks

Tsukuma, Hideaki; Fujimoto, Isaburo; Hanai, Aya; Hiyama, Tomohiko; Kitagawa, Takako; Iwamoto, Noriko

doi:10.1111/j.1349-7006.1994.tb02364.x

Cited by 78 publications

(90 citation statements)

References 8 publications

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“…In particular, the frequency of synchronous or metachronous carcinomas of colorectum and lung was higher than other cancers (1,3). In previous studies, the prognosis of these patients was usually influenced by the site of the second primary carcinoma (4).…”

Section: Introductionmentioning

confidence: 96%

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Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Yamamoto¹,

Taguchi²,

Baba³

et al. 2006

Oncol Rep

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Abstract. The frequency of synchronous or metachronous multiple primary carcinomas in patients with gastrointestinal carcinoma or colorectal carcinoma (CRC) has been reported to be ~10%. We determined the role of hMSH2 and hMLH1 in double carcinomas with both GC and CRC. Fifty-six patients with synchronous or metachronous colorectal carcinoma with gastric carcinoma (CRC with GC), and 69 patients with CRC alone was included in our study. We investigated their clinicopathological characteristics, family history and immunohistochemical stains of hMSH2 and hMLH1 were compared between the patients with CRC alone and those with both CRC with GC. The defective protein expression of hMSH1 and/or hMLH1 in colorectal carcinomas was significantly higher in patients with both CRC with GC than in those with CRC alone (p<0.0001). The survival rate in patients with both CRC with GC was significantly lower than that in those with CRC alone (p<0.01), in addition, the survival rate in patients with defective protein expression of hMSH2 and/or hMLH1 was higher than in those with a positive protein expression of hMSH2 and/or hMLH1 in CRC with GC (p<0.05). The incidence of defective protein expression of hMSH2 and/or hMLH1 in CRC with GC patients suggests that abnormalities in the function of hMSH2 and hMLH1 may play an important role in carcinogenesis. Our findings indicate that the CRC patients who demonstrate a defective protein expression of hMSH2 and/or hMLH1 have a higher risk of developing secondary carcinoma in the gastrointestinal tract.

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Section: Introductionmentioning

confidence: 96%

“…The general frequency of multiple primary carcinomas has been reported to be 10% in Japan and in other countries (1,2). In particular, the frequency of synchronous or metachronous carcinomas of colorectum and lung was higher than other cancers (1,3).…”

Section: Introductionmentioning

confidence: 98%

Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Yamamoto¹,

Taguchi²,

Baba³

et al. 2006

Oncol Rep

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show abstract

“…According to the time criterion, MPCs can be divided into synchronous, i.e., new malignancies that develop within 6 months, and metachronous, i.e., when a new malignancy develops after 6 months [3]. The incidence of MPCs in the general population ranges from 0.75 to 11% [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Impact of smoking on multiple primary cancers survival: a retrospective analysis

2018

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According to available literature, active tobacco smoking enhances the risks of recurrence and development of new primary malignancies. Smoking also shortens the survival period for patients with a diagnosed neoplastic disease. Medical records of 1622 patients hospitalized at the Center for Pulmonary Diseases from January 2013 till March 2017 were retrospectively analyzed, out of which 741 cases with a diagnosis of at least one primary cancer were selected, including 111 patients with multiple primary malignancies. Survival time, the impact of smoking on cancer development and the influence of smoking cessation on the prognosis of the development of new malignancies were analyzed. The incidence of multiple primary malignancies in the population of cancer patients amounted to 14.98%. In the group of smokers, those who ceased smoking developed the second primary malignancy later as compared to those who did not: the period between the first and the new cancer was 11.55 years (SD 7.24) for those who quit smoking, whereas for those who continued to smoke after their first cancer diagnosis it was 6.10 years (SD 8.62) (p = 0.005). It was revealed that patients who had never smoked lived longer than those who had continued to smoke (p = 0.004) and that those who had ceased smoking had a longer survival time than those who had not (p = 0.027). Ceasing smoking after the first cancer diagnosis prolongs the time before a new malignancy develops and is diagnosed, as well as the total survival time after the first cancer diagnosis.

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“…The reported incidence of multiple primary cancers is 0.7-11 % [1][2][3][4]. The primary malignancies arising in multiple organs in a person could be synchronous or metachronous.…”

Section: Discussionmentioning

confidence: 99%

Incidental Intraoperative Discovery of Colonic Growth in a Patient with Esophageal Carcinoma– Lessons Learnt!

2012

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Presentation of more than one malignancy at the intial time of diagnosis is rare. Recently we encountered a patient who was diagnosed with carcinoma esophagus found to have another incidental growth in his right colon at the time of surgery. When managed appropriately such patients do well depending on the stage of their malignancy. Here in this article we have reviewed the literature pertaining to multiple primary malignancy. Keywords Double malignancy . Carcinoma esophagus . Carcinoma colon Case ReportA 54-year-old man presented with complaints of progressive dysphagia and weakness for the past 2 months. Dysphagia was more for solid food than liquid diet. He also had history of loss of appetite and loss of weight, about 5 kg in 2 months. He was a known smoker and alcoholic. On general physical examination, he revealed pallor; otherwise his general condition was unremarkable. Abdominal examination did not reveal any organomegaly or free fluid and was essentially normal. His routine blood counts revealed anemia (hemoglobin 8 g/dl). His renal and liver function tests were reported as normal.Upper gastrointestinal endoscopy revealed ulcerative lesion in the esophagus, starting at 30 cm from incisor and extending up to 35 cm. Biopsy from the ulcer was called out as squamous cell carcinoma. Contrast-enhanced computerized tomography of the thorax and upper abdomen showed wall thickening, involving midthoracic esophagus at the level of the fifth and sixth thoracic vertebrae, with no periesophageal disease or distant metastasis. He was taken up for transthoracic esophagectomy with cervical esophagogastric anastomosis. The right fifth intercostal space approach was used for complete circumferential mobilization of thoracic esophagus from thoracic inlet to diaphragmatic hiatus along with periesophageal lymph nodes. The abdomen was opened by midline supraumbilical laparotomy incision for mobilization of the stomach based on the right gastroepiploic and right gastric vessels. During laparotomy, a strictorous growth involving cecum and ascending colon was incidentally discovered (Fig. 1). Hence, the therapeutic plan was changed to include right radical hemicolectomy with ileocolic anastomosis. After completing ileocolic anastomosis, the gastric tube was prepared and cervical esophagus was mobilized through curved cervical incision. The esophagus was divided and the gastric tube was passed through the posterior mediastinum to the neck. An esophagogastric anastomosis was performed in a single layer.The final histopathology report was called out as adenosquamous carcinoma of the esophagus, involving the muscular wall with no nodal metastasis and tumor-free margins (stage pT2N0M0 , Fig. 2); hemicolectomy specimen was reported as moderately differentiated adenocarcinoma colon with mucinous component, all the lymph nodes and both the cut margins were free of tumor (Astler Coller staging B2). Postoperatively, he was referred to the medical oncology department for adjuvant chemotherapy. He completed 6 months of FOLFOX chem...

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Incidence of Second Primary Cancers in Osaka Residents, Japan, with Special Reference to Cumulative and Relative Risks

Cited by 78 publications

References 8 publications

Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum

Impact of smoking on multiple primary cancers survival: a retrospective analysis

Incidental Intraoperative Discovery of Colonic Growth in a Patient with Esophageal Carcinoma– Lessons Learnt!

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