Incidence of second metachronous head and neck cancers: Population‐based outcomes over 25 years

Tiwana, Manpreet S.; Hay, John; Wu, Jonn; Wong, Frances; Cheung, Winson Y.; Olson, Robert

doi:10.1002/lary.24719

Cited by 34 publications

(40 citation statements)

References 22 publications

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“…There is a large discrepancy between the prevalence of esophageal‐SPTs in patients with HNSCC found with Lugol chromoendoscopy screening (15%, 95% CI: 11‐19) and the prevalence of retrospective non‐screening studies (1%‐6%) . This was also noted by Wang, Lee, et al This discrepancy could indicate that without an active screening program, esophageal‐SPTs are underdiagnosed in patients with HNSCC .…”

Section: Discussionmentioning

confidence: 95%

“…Risk factors for their development include alcohol and tobacco use, age, and the sub‐location of the index tumor (eg, hypopharynx) . Most SPTs in patients with HNSCC occur in the head and neck region, esophagus, and lungs . The risk of esophageal cancer after HNSCC treatment is an 8‐fold to 22‐fold greater than in the general population .…”

Section: Introductionmentioning

confidence: 99%

“…The risk of esophageal cancer after HNSCC treatment is an 8‐fold to 22‐fold greater than in the general population . These SPTs are often diagnosed in advanced stages, which lead to a very low 5‐year survival rate for affected patients . The prevalence of esophageal‐SPTs in patients with HNSCC is estimated to range from 0% to 22% …”

Section: Introductionmentioning

confidence: 99%

“…2 Most SPTs in patients with HNSCC occur in the head and neck region, esophagus, and lungs. 1,[3][4][5][6] The risk of esophageal cancer after HNSCC treatment is an 8-fold to 22-fold greater than in the general population. [7][8][9] These SPTs are often diagnosed in advanced stages, which lead to a very low 5-year survival rate for affected patients.…”

Section: Introductionmentioning

confidence: 99%

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Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

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“…Leur prévention et leur prise en charge précoce restent indispensables. Enfin, les patients en situation de rémis-sion complète après traitement d'un carcinome épidermoïde des voies aérodigestives supérieures sont exposés à un risque de second cancer non négligeable (2 à 5 % par an) [7]. Les objectifs du suivi post-thérapeutique sont l'évaluation du contrôle de la maladie, la mesure et la prise en charge de la toxicité, la détection précoce de seconds cancers.…”

Section: Introductionunclassified

Suivi clinique et paraclinique après radiothérapie pour un cancer des voies aérodigestives supérieures

Clément-Colmou

Troussier

Bardet

et al. 2015

Cancer/Radiothérapie

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The risk of second primary tumors in head and neck cancer: A systematic review

et al. 2019

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Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up.Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population. Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus.Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs. K E Y W O R D Shead and neck cancer, metachronous, second primary tumor, squamous cell carcinoma, synchronous

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Incidence of second metachronous head and neck cancers: Population‐based outcomes over 25 years

Abstract: Oral cavity and oropharyngeal cancers carry the highest risk of a subsequent metachronous HNC. Given the incidence and prognosis of second HNC, future research should address the frequency and duration of screening the head and neck region for a second cancer.

Cited by 34 publications

References 22 publications

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Suivi clinique et paraclinique après radiothérapie pour un cancer des voies aérodigestives supérieures

The risk of second primary tumors in head and neck cancer: A systematic review

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