Incidence of risperidone induced incontinence

Vokas, Constance S.; Steele, Vickie; Norris, Janice I.; Vernon, Lance T.; Brescan, Debra

doi:10.1016/s0920-9964(97)82769-7

Cited by 10 publications

(5 citation statements)

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“…An open cross-sectional study (Vokas et al 1997), including 68 adults with schizophrenia, revealed that 28% of the patients developed urinary incontinence, at least as transient, after initiation of risperidone during a 9-month period, whereas only 13% had such symptoms prior to treatment. Moreover, individuals with developmental disabilities have increased sensitivity to psychotropic agents.…”

Section: Introduction R Isperidone a Widely Prescribed Atypicalmentioning

confidence: 99%

Risperidone-Induced Enuresis in Two Children with Autistic Disorder

Hergüner

Mukaddes

2007

Journal of Child and Adolescent Psychopharmacology

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Although the pathophysiology of antipsychotic-induced enuresis remains unclear, a number of mechanisms including alpha(1)-adrenergic blockade, dopamine blockade, and antimuscarinic effects has been proposed. Olanzapine has lower alpha(1)-adrenergic and dopaminergic blockade properties, thus changing risperidone to olanzapine may be an alternative modality in risperidone-induced enuresis when antipsychotic treatment is crucial. Clinicians should be more vigilant about screening for this side effect, especially in younger population with developmental disabilities.

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Section: Introduction R Isperidone a Widely Prescribed Atypicalmentioning

confidence: 99%

Risperidone-Induced Enuresis in Two Children with Autistic Disorder

Hergüner

Mukaddes

2007

Journal of Child and Adolescent Psychopharmacology

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“…Urinary disturbances as a result of clozapine therapy have been well documented, and include incontinence, enuresis and urgency [4,5,32]. Other atypical antipsychotics, such as risperidone [7] and olanzapine [10] have been reported to produce urinary incontinence.…”

Section: Discussionmentioning

confidence: 99%

“…Since clozapine has potent anti-muscarinic and anti-alpha adrenergic effects [2], it has been proposed that peripheral effects on the lower urinary tract might be responsible for the micturition disturbances [6]. Incontinence has also been reported following therapy with other atypical neuroleptics such as risperidone [7-9] and recently, olanzapine [10]. …”

Section: Introductionmentioning

confidence: 99%

Central effects of clozapine in regulating micturition in anesthetized rats

et al. 2002

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Background : We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited the external urethral sphincter. Since clozapine acts at several receptor types both at the periphery and the central nervous system, the site of action remained uncertain. Therefore, the purpose of this study was to determine the effects of central administration of clozapine on the bladder and the external urethral sphincter during cystometry and to examine differences in spinal versus supraspinal administration. We extended our observations by delivering clozapine centrally in anesthetized rats instrumented with either an intrathecal (L6-S1 spinal segment) or an intracerebroventricular (lateral ventricle) catheter.

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“…In one report, twenty-eight (28%) of patients on risperidone developed at least transient urinary incontinence, compared to 13% before starting treatment [18]. Other reports also suggest urinary incontinence associated with risperidone therapy [17,19].…”

Section: Discussionmentioning

confidence: 99%

Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats

2001

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Background: A previous report showed that the atypical neuroleptic clozapine resulted in marked changes in urodynamic parameters and greatly inhibited the activity of the external urethral sphincter in anesthetized rats. Such findings may help explain the high incidence of urinary disturbances reported during clozapine therapy. In an effort to extend our observations to other atypical neuroleptic agents, the present study investigated the effects of two newer atypical antipsychotics, olanzapine and risperidone, on the bladder and external urethral sphincter during cystometry in anesthetized rats.

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Incidence of risperidone induced incontinence

Cited by 10 publications

References 0 publications

Risperidone-Induced Enuresis in Two Children with Autistic Disorder

Risperidone-Induced Enuresis in Two Children with Autistic Disorder

Central effects of clozapine in regulating micturition in anesthetized rats

Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats

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