Incidence of Rectal Injury After Radical Prostatectomy: A Systematic Review and Meta-analysis

Romito, Ilaria; Giannarini, Gianluca; Rossanese, Marta; Mucciardi, Giuseppe; Simonato, Alchiede; Ficarra, Vincenzo

doi:10.1016/j.euros.2023.03.017

Cited by 1 publication

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References 108 publications

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“…A reduction in the number of patients indicated for biopsy could possibly result in less morbidity and discomfort for patients and a reduction in costs for society 2 Nonetheless, to consider omitting a biopsy, near‐perfect specificity is essential. This is because the minor inconvenience of a prostate biopsy is outweighed by the potential side effects and complications of unnecessary active PCa treatment 2,30,31 …”

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confidence: 99%

The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

Heetman,

Paulino Pereira,

Kelder

et al. 2024

The Prostate

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BackgroundPrebiopsy magnetic resonance imaging (MRI) increases the detection rate of clinically significant prostate cancer (csPCa). Prostate‐specific membrane antigen‐positron emission tomography/computed tomography (PSMA PET/CT) maximum standardized uptake value (SUVmax) of the prostate may offer additional value in predicting the likelihood of csPCa in biopsy.MethodsA single‐center cohort study involving patients with biopsy‐proven PCa who underwent both MRI and PSMA PET/CT between 2020 and 2021. Logistic regression models were developed for International Society of Urological Pathology (ISUP) Grade Group (GG) ≥ 2 and GG ≥ 3 using noninvasive prebiopsy parameters: age, (log‐)prostate‐specific antigen (PSA) density, PI‐RADS 5 lesion presence, extraprostatic extension (EPE) on MRI, and SUVmax of the prostate. Models with and without SUVmax were compared using Likelihood ratio tests and area under the curve (AUC). DeLong's test was used to compare the AUCs.ResultsThe study included 386 patients, with 262 (68%) having ISUP GG ≥ 2 and 180 (47%) having ISUP GG ≥ 3. Including SUVmax significantly improved both models' goodness of fit (p < 0.001). The GG ≥ 2 model had a higher AUC with SUVmax 89.16% (95% confidence interval [CI]: 86.06%–92.26%) than without 87.34% (95% CI: 83.93%–90.76%) (p = 0.026). Similarly, the GG ≥ 3 model had a higher AUC with SUVmax 82.51% (95% CI: 78.41%–86.6%) than without 79.33% (95% CI: 74.84%–83.83%) (p = 0.003). The SUVmax inclusion improved the GG ≥ 3 model's calibration at higher probabilities.ConclusionSUVmax of the prostate on PSMA PET/CT potentially improves diagnostic accuracy in predicting the likelihood of csPCa in prostate biopsy.

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Section: Discussionmentioning

confidence: 99%

The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

Heetman,

Paulino Pereira,

Kelder

et al. 2024

The Prostate

View full text Add to dashboard Cite

show abstract

Incidence of Rectal Injury After Radical Prostatectomy: A Systematic Review and Meta-analysis

Cited by 1 publication

References 108 publications

The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

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Incidence of Rectal Injury After Radical Prostatectomy: A Systematic Review and Meta-analysis

Cited by 1 publication

References 108 publications

The additional value of 68Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

The additional value of 68Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

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The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

The additional value of ⁶⁸Ga‐PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy