Incidence of Radiation Caries in Patients Undergoing Radiation Therapy in the Head and Neck Region

Konjhodžić, Alma; Keros, Jadranka; Ajanović, Muhamed; Smajkic, Nedim; Hasić-Branković, Lajla

doi:10.4034/1519.0501.2010.0103.0024

Cited by 7 publications

(4 citation statements)

References 14 publications

(23 reference statements)

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“…In Bosnian population, Konjhodzic-Prcic et al [2] reported caries incremental rate of 3.5/month for irradiated head and neck cancer patients. However, there was no caries protective regimen mentioned.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of Fluoride Varnish Application as Cariostatic and Desensitizing Agent in Irradiated Head and Neck Cancer Patients

Dholam

Somani

Prabhu

et al. 2013

International Journal of Dentistry

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Objective. To evaluate the effectiveness of three-month fluoride varnish application on radiation caries and dental sensitivity and to assess compliance to three-month fluoride varnish application. Materials and Methods. 190 irradiated head and neck cancer patients were randomly selected and reviewed retrospectively. Oral prophylaxis, fluoride varnish application, and treatment of dental caries were done prior to radiation therapy. Patients were followed up at every three months for dental evaluation and fluoride varnish application. Decayed-missing-filling-teeth indices, dental sensitivity, and compliance to fluoride varnish application were noted for fifteen months and analyzed statistically. Results. Significant increase in decayed-missing-filling-teeth index was seen at nine (P = 0.028), twelve (P = 0.003) and fifteen (P = 0.002) months follow-up. However, the rate of increase in decayed-missing-filling-teeth indices was 1.64/month which is less than the rate mentioned in the literature (2.5/month). There was no significant effect of sex (P = 0.952) and surgery (P = 0.672) on radiation caries, but site of disease (P = 0.038) and radiation dose (P = 0.015) were found to have statistically significant effect. Dental sensitivity decreased from 39% at 3 months to 25% at 15 months followup. 99% compliance to fluoride varnish application was seen till six months followup which decreased to 46% at fifteen months. Conclusion. Three-month fluoride varnish application is effective in decreasing radiation caries and sensitivity and has good compliance.

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Section: Discussionmentioning

confidence: 99%

“…It is highly destructive with a rapid onset, progression, and nonspecific localization. Xerostomia is the main risk factor [2]. An ideal approach to prevent radiation caries is quantitative and qualitative modification of saliva [1].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Fluoride Varnish Application as Cariostatic and Desensitizing Agent in Irradiated Head and Neck Cancer Patients

Dholam

Somani

Prabhu

et al. 2013

International Journal of Dentistry

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“…Intensity-modulated radiation therapy (IMRT) can accurately deliver radiation dose to targets while sparing adjacent normal organs with intensity modulation of high-energy photon beams so that it has favorable treatment outcomes for NPC [ 2 , 3 ]. Nevertheless, serious complications frequently occur during or after IMRT, such as xerostomia [ 4 ], radiation caries [ 5 ], dysphagia [ 6 ], taste impairment [ 7 ], and radiation-induced brain injury [ 8 ]. Thus, balancing the high-dose coverage to targets and minimum-dose exposure to organs at risk (OARs) is crucial.…”

Section: Introductionmentioning

confidence: 99%

Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma

Cai,

Ding,

et al. 2024

Radiat Oncol

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Background At present, the implementation of intensity-modulated radiation therapy (IMRT) treatment planning for geometrically complex nasopharyngeal carcinoma (NPC) through manual trial-and-error fashion presents challenges to the improvement of planning efficiency and the obtaining of high-consistency plan quality. This paper aims to propose an automatic IMRT plan generation method through fluence prediction and further plan fine-tuning for patients with NPC and evaluates the planning efficiency and plan quality. Methods A total of 38 patients with NPC treated with nine-beam IMRT were enrolled in this study and automatically re-planned with the proposed method. A trained deep learning model was employed to generate static field fluence maps for each patient with 3D computed tomography images and structure contours as input. Automatic IMRT treatment planning was achieved by using its generated dose with slight tightening for further plan fine-tuning. Lastly, the plan quality was compared between automatic plans and clinical plans. Results The average time for automatic plan generation was less than 4 min, including fluence maps prediction with a python script and automated plan tuning with a C# script. Compared with clinical plans, automatic plans showed better conformity and homogeneity for planning target volumes (PTVs) except for the conformity of PTV-1. Meanwhile, the dosimetric metrics for most organs at risk (OARs) were ameliorated in the automatic plan, especially Dmax of the brainstem and spinal cord, and Dmean of the left and right parotid glands significantly decreased (P < 0.05). Conclusion We have successfully implemented an automatic IMRT plan generation method for patients with NPC. This method shows high planning efficiency and comparable or superior plan quality than clinical plans. The qualitative results before and after the plan fine-tuning indicates that further optimization using dose objectives generated by predicted fluence maps is crucial to obtain high-quality automatic plans.

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“…Gamma radiation therapy is still used in the treatment of patients with oral cancer (1,2) , but it might have serious negative dental and oral effects. Orofacial tissues, oral mucosa, salivary glands, taste, dentition, periodontium, bone, muscles, and joints are all affected by radiation (3) . The impact of radiotherapy on the structure of the teeth is, however, a subject of scant research.…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF GAMMA-RADIATION ON DE- AND RE-MINERALIZATION OF ENAMEL AND DENTIN (An IN-VITRO STUDY)

ahmed ha,

Abo Elezz,

Elmaghraby

2024

Dental Science Updates

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Introduction: Gamma radiation is usually used, as a primary or supplementary treatment, for oral cancer patients. Aim: The present work was undertaken to investigate, in vitro, the effect gamma irradiation of a cumulative dose of 60 Gy (20 Gy/day over three days) on enamel and dentin microhardness before and after demineralization and remineralization. Materials and methods: Ten healthy freshly extracted human third molars were used in this study. The teeth specimens were cut perpendicular to their occlusal surface into two halves. Half of the specimens were gamma-irradiated to a dose of 60 Gy (20 Gy/day). The data involved the measurement of VHN Vickers microhardness on both radiated and non-irradiated. Results: The results indicated that the mean microhardness values of the non-irradiated enamel samples were decreased after gamma irradiation, and were significantly decreased after demineralization; meanwhile, the microhardness values of the demineralized non-irradiated enamel samples were significantly increased after remineralization. The results showed that the microhardness of the demineralized non-irradiated dentin samples was increased, and that the microhardness of the gamma-irradiated dentin samples was slightly decreased. Conclusions: gamma-irradiation had significant effect on enamel and dentin microhardness values and had significant decrease effect on demineralization of enamel while had significant increase by remineralization.

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Incidence of Radiation Caries in Patients Undergoing Radiation Therapy in the Head and Neck Region

Cited by 7 publications

References 14 publications

Effectiveness of Fluoride Varnish Application as Cariostatic and Desensitizing Agent in Irradiated Head and Neck Cancer Patients

Effectiveness of Fluoride Varnish Application as Cariostatic and Desensitizing Agent in Irradiated Head and Neck Cancer Patients

Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma

EFFECT OF GAMMA-RADIATION ON DE- AND RE-MINERALIZATION OF ENAMEL AND DENTIN (An IN-VITRO STUDY)

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