Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999–2009

Melkonian, Stephanie C.; Jim, Melissa A.; Reilley, Brigg; Erdrich, Jennifer; Berkowitz, Zahava; Wiggins, Charles L.; Haverkamp, Donald; White, Mary C.

doi:10.1007/s10552-018-1059-3

Cited by 20 publications

(19 citation statements)

References 30 publications

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“…All six studies from the USA consistently reported increasing incidence between 2011 and 2015 (28) or over recent decades (23)(24)(25)(26)(27). These increases were evident among persons (23,24,26) and by sex (23,25,27,28). In Colombia, trends increased in males but were stable among females from 2008 to 2012 (29).…”

Section: Liver Cancers Combinedmentioning

confidence: 97%

“…Two studies found increasing liver cancer rates overall for each analyzed racial/ethnic group (23,25) while another reported increasing trends among non-Hispanic Whites for both sexes, whereas they decreased among Asian/Pacific Islander (API) men and were stable among API women (27) ( Supplementary Table 3.5). Incidence trends over the most recent 5-year period (2011-2015) also increased among both males and females for six major racial and ethnic groups in the USA except Hispanic men and API women (both with stable trends) and API men (decreasing trends) (28).…”

Section: Trends By Race And/or Ethnicity (Usa Only)mentioning

confidence: 99%

“…Many of the included studies highlighted the importance of continuing efforts to reduce the risks associated with viral hepatitis through primary (HBV vaccination) (23,25,27,48,49,60) and secondary prevention efforts. The latter include screening of high-risk populations (23,31,47,49,(51)(52)(53)61) and ensuring equitable access to curative therapies for HBV/HCV infections among all population subgroups (23,32,37,47,48,52,53,59). However, even if incidence of HCV-related HCC decreases in the future due to improved treatments and better control (75,81), this may be offset by the emerging etiological importance of NAFLD as a key risk factor (77,82).…”

Section: Proposed Drivers Of Incidence Trendsmentioning

confidence: 99%

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Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Primary liver cancer is a leading cause of cancer deaths worldwide. Global burden varies, reflecting geographical distribution of viral hepatitis. Our objective was to perform a systematic review and meta-analysis of published current trends in incidence of adult liver cancers and histological types worldwide. Methods: This study used systematic searches of PubMed, Embase, CINAHL, and Web of Science databases for English-language peer-reviewed articles published from 1 January 2008 to 01 September 2019. Inclusion criteria were population-based studies of adult liver cancer patients with quantitative estimates of temporal trends in incidence for liver cancers and/or histological types. For multiple studies from the same geographical area, only the publication that reported the most recent trends for the same cancer type and population subgroup was included. Review was conducted per PRISMA guidelines. Two authors independently extracted data and critically assessed studies. Proposed contributors to observed trends were extracted from included articles. Study-specific estimates of the annual percentage change (APC) in incidence rates with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis models. Heterogeneity was measured using the I 2 statistics and publication bias evaluated using funnel plots and Egger's tests. Results: Overall, 53 studies met the inclusion criteria, of which 31 were included in the meta-analysis. Overall, pooled APC estimates were +0.8 (95% CI −0.3, +2.0) for liver cancers combined, +2.6 (95% CI +1.2, +4.0) for hepatocellular carcinoma (HCC), and +4.3 (95% CI +2.5, +6.1) for intrahepatic cholangiocarcinoma. Subgroup analyses indicated increasing trends for liver cancers (APC +3.2, 95% CI +2.5, +3.9) and HCC (APC +3.6, 95% CI +2.9, +4.4) in the region of North America/Europe/Australia, whereas corresponding trends were decreasing (APC −1.7, 95% CI −2.2, −1.1) and stable (APC −0.7, 95% CI −1.9, +0.5) in Asia, respectively. Dasgupta et al. Liver Cancer Incidence Trends Meta-Analysis Conclusions: Incidence is increasing for adult liver cancers and HCC in Western countries, whereas trends are decreasing in the Asian region, although still remaining high. Our findings highlight the importance of viral hepatitis control and lifestyle interventions to reduce global liver cancer burden. Ongoing surveillance is also vital to detect early shifts in incidence trends.

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Section: Liver Cancers Combinedmentioning

confidence: 97%

Section: Trends By Race And/or Ethnicity (Usa Only)mentioning

confidence: 99%

Section: Proposed Drivers Of Incidence Trendsmentioning

confidence: 99%

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Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

et al. 2020

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“…Moreover, the maleto-female relative risk for liver cancer incidence in AI/ ANs was lower than those in other racial/ethnic groups, indicating that the sex difference in liver cancer incidence among AI/ANs is less prominent than in other racial/ethnic groups. In a recent incidence analysis from 1999 to 2009 using Indian Health Service linked national cancer registry data, Melkonian et al [36] also found that liver cancer incidence is increasing among AI/ANs. In addition, they found that alcohol use and obesity were correlated with liver cancer incidence among AI/ANs by region and that AI/ANs were diagnosed at later stages than whites.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have highlighted important racial/ethnic disparities in liver cancer with respect to incidence [30][31][32][33][34][35][36], mortality [31,32,34], survival [30,32,[37][38][39], and treatment [37,40]. Further, sex-based disparities in incidence [31,[41][42][43][44], mortality [31,34,42], and survival [39] trends have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Changing trends in liver cancer incidence by race/ethnicity and sex in the US: 1992–2016

Salvatore

Jeon

Meza

2019

Cancer Causes Control

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Purpose Liver cancer incidence continues to increase while incidence of most other cancers is decreasing. We analyze recent and long-term trends of US liver cancer incidence by race/ethnicity and sex to best understand where to focus preventive efforts. Methods Liver cancer incidence rates from 1992 to 2016 were obtained from the Surveillance, Epidemiology, and End Results registry. Delay-adjusted age-standardized incidence trends by race/ethnicity and sex were analyzed using joinpoint regression. Age-specific incidence was analyzed using age-period-cohort models. Hepatitis C seroprevalence by cohort was calculated using National Health and Nutrition Examination Survey data. Results Liver cancer incidence has peaked in males and Asian or Pacific Islanders. Hispanic males, a high-incidence population, are experiencing a decrease in incidence, although not yet statistically significant. In contrast, incidence continues to increase in females, although at lower rates than in the 1990s, and American Indian/Alaska Natives (AI/ANs). Liver cancer incidence continues to be higher in males. Non-Hispanic Whites have the lowest incidence among racial/ethnic groups. Trends largely reflect differences in incidence by birth-cohort, which increased considerably, particularly in males, for those born around the 1950s, and continues to increase in females and AI/ANs. The patterns in males are likely driven by cohort variations in Hepatitis C infection. Conclusions Liver cancer incidence appears to have peaked among males. However, important differences in liver cancer trends by race/ethnicity and sex remain, highlighting the need for monitoring trends across different groups. Preventive interventions should focus on existing liver cancer disparities, targeting AI/ANs, females, and high-incidence groups.

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Disparities in pancreatic cancer care and research in Native Americans: Righting a history of wrongs

First

Sutton

Shannon

et al. 2022

Cancer

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Disparities in pancreatic cancer incidence and outcomes exist in Native American populations. These disparities are multifactorial, difficult to quantify, and are influenced by historical, socioeconomic, and health care structural factors. The objective of this article was to assess these factors and offer a call to action to overcome them. The authors reviewed published data on pancreatic cancer in Native American populations with a focus on disparities in incidence, outcomes, and research efforts. The historical context of the interactions between Native Americans and the United States health care system was also analyzed to form actionable items to build trust and collaboration. The incidence of pancreatic cancer in Native Americans is higher than that in the general US population and has the worst survival of any major racial or ethnic group. These outcomes are influenced by a patient population with often poor access to high‐quality cancer care, historical trauma potentially leading to reduced care utilization, and a lack of research focused on etiologies and comorbid conditions that contribute to these disparities. A collaborative effort between nontribal and tribal leaders and cancer centers is key to addressing disparities in pancreatic cancer outcomes and research. More population‐level studies are needed to better understand the incidence, etiologies, and comorbid conditions of pancreatic cancer in Native Americans. Finally, a concerted, focused effort should be undertaken between nontribal and tribal entities to increase the access of Native Americans to high‐quality care for pancreatic cancer and other lethal malignancies.

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Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999–2009

Abstract: Findings highlight disparities in liver cancer incidence between AI/AN and white populations and emphasize opportunities to decrease liver cancer risk factor prevalence.

Cited by 20 publications

References 30 publications

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

Changing trends in liver cancer incidence by race/ethnicity and sex in the US: 1992–2016

Disparities in pancreatic cancer care and research in Native Americans: Righting a history of wrongs

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